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Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases.
FEBS Lett. 1997 Aug 04; 412(3):578-82.FL

Abstract

Tau proteins aggregate into different neuronal inclusions in several neurodegenerative disorders. In Alzheimer's disease (AD), hyperphosphorylated Tau from paired helical filaments (PHF) of neurofibrillary tangles, named PHF-Tau, have an electrophoretic profile with four main bands (Tau 55, 64, 69, 74 kDa). In Pick's disease, phosphorylated Tau from Pick bodies are made of two major components (Tau 55, 64 kDa) and a minor 69 kDa. Here we show, using specific antibodies against translated exon 2, 3 or 10 of Tau isoforms, that the set of Tau isoforms engaged in the most insoluble part of PHF in AD is made of Tau isoforms with exon 10 while they are lacking in phosphorylated Tau from Pick's disease. Our results suggest that specific sets of Tau isoforms distinguish between typical neuronal inclusions.

Authors+Show Affiliations

INSERM Unité 422, Lille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9276470

Citation

Sergeant, N, et al. "Different Distribution of Phosphorylated Tau Protein Isoforms in Alzheimer's and Pick's Diseases." FEBS Letters, vol. 412, no. 3, 1997, pp. 578-82.
Sergeant N, David JP, Lefranc D, et al. Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases. FEBS Lett. 1997;412(3):578-82.
Sergeant, N., David, J. P., Lefranc, D., Vermersch, P., Wattez, A., & Delacourte, A. (1997). Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases. FEBS Letters, 412(3), 578-82.
Sergeant N, et al. Different Distribution of Phosphorylated Tau Protein Isoforms in Alzheimer's and Pick's Diseases. FEBS Lett. 1997 Aug 4;412(3):578-82. PubMed PMID: 9276470.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different distribution of phosphorylated tau protein isoforms in Alzheimer's and Pick's diseases. AU - Sergeant,N, AU - David,J P, AU - Lefranc,D, AU - Vermersch,P, AU - Wattez,A, AU - Delacourte,A, PY - 1997/8/4/pubmed PY - 1997/8/4/medline PY - 1997/8/4/entrez SP - 578 EP - 82 JF - FEBS letters JO - FEBS Lett VL - 412 IS - 3 N2 - Tau proteins aggregate into different neuronal inclusions in several neurodegenerative disorders. In Alzheimer's disease (AD), hyperphosphorylated Tau from paired helical filaments (PHF) of neurofibrillary tangles, named PHF-Tau, have an electrophoretic profile with four main bands (Tau 55, 64, 69, 74 kDa). In Pick's disease, phosphorylated Tau from Pick bodies are made of two major components (Tau 55, 64 kDa) and a minor 69 kDa. Here we show, using specific antibodies against translated exon 2, 3 or 10 of Tau isoforms, that the set of Tau isoforms engaged in the most insoluble part of PHF in AD is made of Tau isoforms with exon 10 while they are lacking in phosphorylated Tau from Pick's disease. Our results suggest that specific sets of Tau isoforms distinguish between typical neuronal inclusions. SN - 0014-5793 UR - https://www.unboundmedicine.com/medline/citation/9276470/Different_distribution_of_phosphorylated_tau_protein_isoforms_in_Alzheimer's_and_Pick's_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-5793(97)00859-4 DB - PRIME DP - Unbound Medicine ER -