Tags

Type your tag names separated by a space and hit enter

Indirect hemagglutination antibodies against Burkholderia pseudomallei in normal blood donors and suspected cases of melioidosis in Malaysia.

Abstract

Interpretation of the indirect hemagglutination test (IHA) for melioidosis in endemic areas is difficult because of the presence of antibodies in apparently healthy individuals. Fifty-three out of 200 healthy blood donors in Malaysia showed positive antibody titers (> or = 1 : 40) against Burkholderia pseudomallei. Seven percent had an IHA titer of 1 : 40, 11% had an IHA titer of 1 : 80 while 8.5% had a titer > or = 1 : 160. Out of 258 sera sent for melioidosis serology, 7% of the patients had an IHA titer of 1 : 40, 9% had an IHA titer of 1 : 80 while 20% had an IHA titer of > or = 1 : 160. If a titer of > or = 1 : 80 is taken as cut off point for positivity, 29% of the patients had positive melioidosis serology. Increasing the positivity threshold may jeopardize the sensitivity of the test. A more specific and sensitive test is needed.

Authors+Show Affiliations

Institute for Medical Research, Kuala Lumpur, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9279987

Citation

Norazah, A, et al. "Indirect Hemagglutination Antibodies Against Burkholderia Pseudomallei in Normal Blood Donors and Suspected Cases of Melioidosis in Malaysia." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 27, no. 2, 1996, pp. 263-6.
Norazah A, Rohani MY, Chang PT, et al. Indirect hemagglutination antibodies against Burkholderia pseudomallei in normal blood donors and suspected cases of melioidosis in Malaysia. Southeast Asian J Trop Med Public Health. 1996;27(2):263-6.
Norazah, A., Rohani, M. Y., Chang, P. T., & Kamel, A. G. (1996). Indirect hemagglutination antibodies against Burkholderia pseudomallei in normal blood donors and suspected cases of melioidosis in Malaysia. The Southeast Asian Journal of Tropical Medicine and Public Health, 27(2), 263-6.
Norazah A, et al. Indirect Hemagglutination Antibodies Against Burkholderia Pseudomallei in Normal Blood Donors and Suspected Cases of Melioidosis in Malaysia. Southeast Asian J Trop Med Public Health. 1996;27(2):263-6. PubMed PMID: 9279987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indirect hemagglutination antibodies against Burkholderia pseudomallei in normal blood donors and suspected cases of melioidosis in Malaysia. AU - Norazah,A, AU - Rohani,M Y, AU - Chang,P T, AU - Kamel,A G, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 263 EP - 6 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 27 IS - 2 N2 - Interpretation of the indirect hemagglutination test (IHA) for melioidosis in endemic areas is difficult because of the presence of antibodies in apparently healthy individuals. Fifty-three out of 200 healthy blood donors in Malaysia showed positive antibody titers (> or = 1 : 40) against Burkholderia pseudomallei. Seven percent had an IHA titer of 1 : 40, 11% had an IHA titer of 1 : 80 while 8.5% had a titer > or = 1 : 160. Out of 258 sera sent for melioidosis serology, 7% of the patients had an IHA titer of 1 : 40, 9% had an IHA titer of 1 : 80 while 20% had an IHA titer of > or = 1 : 160. If a titer of > or = 1 : 80 is taken as cut off point for positivity, 29% of the patients had positive melioidosis serology. Increasing the positivity threshold may jeopardize the sensitivity of the test. A more specific and sensitive test is needed. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/9279987/Indirect_hemagglutination_antibodies_against_Burkholderia_pseudomallei_in_normal_blood_donors_and_suspected_cases_of_melioidosis_in_Malaysia_ L2 - https://medlineplus.gov/bloodtransfusionanddonation.html DB - PRIME DP - Unbound Medicine ER -