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The evaluation of the 29 and 31 kDa antigens in female Angiostrongylus cantonensis for serodiagnosis of human angiostrongyliasis.

Abstract

The objective of this study was to evaluate the crude somatic extract of female Angiostrongylus cantonensis by ELISA and to evaluate the 29 kDa and the 31 kDa components of female worm by EITB for serodiagnosis of human angiostrongyliasis. Using ELISA, cross reaction occurred among all sera tested except capillariasis. The sensitivity, specificity, positive and negative predictive values of ELISA were found to be 100%, 66.8%, 27.1% and 100% respectively. Using EITB, The 29 kDa component cross-reacted with most of the heterologous sera while the 31 kDa component was recognized by 69.2% (18/26) sera from angiostrongyliasis patients, cross-reacted only with trichinellosis, trichuriasis and opisthorchiasis sera. This component may possibly used as reliable agents for angiostrongyliasis out of other tissue infected helminthiasis. The sensitivity, specificity, positive and negative predictive values of EITB for the 31.0 kDa component were 69.2%, 82.4%, 46.2% and 92.5% respectively.

Authors+Show Affiliations

Department of Parasitology, School of Medicine, Hiroshima University, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9279992

Citation

Nuamtanong, S. "The Evaluation of the 29 and 31 kDa Antigens in Female Angiostrongylus Cantonensis for Serodiagnosis of Human Angiostrongyliasis." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 27, no. 2, 1996, pp. 291-6.
Nuamtanong S. The evaluation of the 29 and 31 kDa antigens in female Angiostrongylus cantonensis for serodiagnosis of human angiostrongyliasis. Southeast Asian J Trop Med Public Health. 1996;27(2):291-6.
Nuamtanong, S. (1996). The evaluation of the 29 and 31 kDa antigens in female Angiostrongylus cantonensis for serodiagnosis of human angiostrongyliasis. The Southeast Asian Journal of Tropical Medicine and Public Health, 27(2), 291-6.
Nuamtanong S. The Evaluation of the 29 and 31 kDa Antigens in Female Angiostrongylus Cantonensis for Serodiagnosis of Human Angiostrongyliasis. Southeast Asian J Trop Med Public Health. 1996;27(2):291-6. PubMed PMID: 9279992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The evaluation of the 29 and 31 kDa antigens in female Angiostrongylus cantonensis for serodiagnosis of human angiostrongyliasis. A1 - Nuamtanong,S, PY - 1996/6/1/pubmed PY - 1996/6/1/medline PY - 1996/6/1/entrez SP - 291 EP - 6 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 27 IS - 2 N2 - The objective of this study was to evaluate the crude somatic extract of female Angiostrongylus cantonensis by ELISA and to evaluate the 29 kDa and the 31 kDa components of female worm by EITB for serodiagnosis of human angiostrongyliasis. Using ELISA, cross reaction occurred among all sera tested except capillariasis. The sensitivity, specificity, positive and negative predictive values of ELISA were found to be 100%, 66.8%, 27.1% and 100% respectively. Using EITB, The 29 kDa component cross-reacted with most of the heterologous sera while the 31 kDa component was recognized by 69.2% (18/26) sera from angiostrongyliasis patients, cross-reacted only with trichinellosis, trichuriasis and opisthorchiasis sera. This component may possibly used as reliable agents for angiostrongyliasis out of other tissue infected helminthiasis. The sensitivity, specificity, positive and negative predictive values of EITB for the 31.0 kDa component were 69.2%, 82.4%, 46.2% and 92.5% respectively. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/9279992/The_evaluation_of_the_29_and_31_kDa_antigens_in_female_Angiostrongylus_cantonensis_for_serodiagnosis_of_human_angiostrongyliasis_ L2 - http://www.diseaseinfosearch.org/result/468 DB - PRIME DP - Unbound Medicine ER -