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[Study on coagulation fibrinolytic systems in predialysis patients with chronic renal failure--comparison between patients with chronic glomerulonephritis and patients with diabetic nephropathy].
Nihon Jinzo Gakkai Shi. 1997 Jul; 39(5):474-82.NJ

Abstract

To clarify the abnormalities of coagulation and fibrinolytic systems on predialysis patients with chronic renal failure, we measured indices of coagulation and fibrinolytic systems in 33 predialysis patients whose creatinine (Cr) levels were over 3.0 mg/dl. We termed twenty-four patients with chronic glomerulonephritis the "CGN group". We also termed nine patients wit diabetes mellitus the "DM group". We measured thrombin.antithrombin III complex (TAT), alpha 2-plasmin inhibitor plasmin complex (PIC), D-dimer, protein C, protein S, thrombomodulin (TM), vitronectin, tissue plasminogen activator.plasminogen activator inhibitor-1 complex (tPAI-C) in theses two groups. Furthermore, we measured the same indices after 6 months in the CGN group. As a result, the plasma levels of both TAT, PIC, TM/Cr ration in the DM group were significantly higher that those in the CGN group, changes in both protein S activities and plasma levels of tPAI-C were reduced significantly after 6 months. In conclusion, the abnormalities of coagulation and fibrinolytic systems in predialysis diabetic patients were stronger than those in predialysis patients with CGN. Furthermore, these abnormalities were worsened after 6 months in predialysis patients with chronic renal failure.

Authors+Show Affiliations

Department of Internal Medicine III, Okayama University Medical School, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Multicenter Study

Language

jpn

PubMed ID

9283213

Citation

Nagake, Y, et al. "[Study On Coagulation Fibrinolytic Systems in Predialysis Patients With Chronic Renal Failure--comparison Between Patients With Chronic Glomerulonephritis and Patients With Diabetic Nephropathy]." Nihon Jinzo Gakkai Shi, vol. 39, no. 5, 1997, pp. 474-82.
Nagake Y, Makino H, Yorioka N, et al. [Study on coagulation fibrinolytic systems in predialysis patients with chronic renal failure--comparison between patients with chronic glomerulonephritis and patients with diabetic nephropathy]. Nihon Jinzo Gakkai Shi. 1997;39(5):474-82.
Nagake, Y., Makino, H., Yorioka, N., Nomura, S., Osawa, G., Yamakido, M., Kawasaki, H., Kato, Y., Matsuzaki, M., Shikata, K., Uemasu, J., Somiya, H., Fujii, Z., Hayashida, S., Nasu, T., Oyabu, Y., Nitta, Y., Kawanishi, H., Usui, K., ... Ota, Z. (1997). [Study on coagulation fibrinolytic systems in predialysis patients with chronic renal failure--comparison between patients with chronic glomerulonephritis and patients with diabetic nephropathy]. Nihon Jinzo Gakkai Shi, 39(5), 474-82.
Nagake Y, et al. [Study On Coagulation Fibrinolytic Systems in Predialysis Patients With Chronic Renal Failure--comparison Between Patients With Chronic Glomerulonephritis and Patients With Diabetic Nephropathy]. Nihon Jinzo Gakkai Shi. 1997;39(5):474-82. PubMed PMID: 9283213.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on coagulation fibrinolytic systems in predialysis patients with chronic renal failure--comparison between patients with chronic glomerulonephritis and patients with diabetic nephropathy]. A1 - Nagake,Y, AU - Makino,H, AU - Yorioka,N, AU - Nomura,S, AU - Osawa,G, AU - Yamakido,M, AU - Kawasaki,H, AU - Kato,Y, AU - Matsuzaki,M, AU - Shikata,K, AU - Uemasu,J, AU - Somiya,H, AU - Fujii,Z, AU - Hayashida,S, AU - Nasu,T, AU - Oyabu,Y, AU - Nitta,Y, AU - Kawanishi,H, AU - Usui,K, AU - Fujiwara,K, AU - Takasugi,N, AU - Kanehara,K, AU - Hamaguchi,N, AU - Kumagai,I, AU - Ota,Z, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 474 EP - 82 JF - Nihon Jinzo Gakkai shi JO - Nihon Jinzo Gakkai Shi VL - 39 IS - 5 N2 - To clarify the abnormalities of coagulation and fibrinolytic systems on predialysis patients with chronic renal failure, we measured indices of coagulation and fibrinolytic systems in 33 predialysis patients whose creatinine (Cr) levels were over 3.0 mg/dl. We termed twenty-four patients with chronic glomerulonephritis the "CGN group". We also termed nine patients wit diabetes mellitus the "DM group". We measured thrombin.antithrombin III complex (TAT), alpha 2-plasmin inhibitor plasmin complex (PIC), D-dimer, protein C, protein S, thrombomodulin (TM), vitronectin, tissue plasminogen activator.plasminogen activator inhibitor-1 complex (tPAI-C) in theses two groups. Furthermore, we measured the same indices after 6 months in the CGN group. As a result, the plasma levels of both TAT, PIC, TM/Cr ration in the DM group were significantly higher that those in the CGN group, changes in both protein S activities and plasma levels of tPAI-C were reduced significantly after 6 months. In conclusion, the abnormalities of coagulation and fibrinolytic systems in predialysis diabetic patients were stronger than those in predialysis patients with CGN. Furthermore, these abnormalities were worsened after 6 months in predialysis patients with chronic renal failure. SN - 0385-2385 UR - https://www.unboundmedicine.com/medline/citation/9283213/[Study_on_coagulation_fibrinolytic_systems_in_predialysis_patients_with_chronic_renal_failure__comparison_between_patients_with_chronic_glomerulonephritis_and_patients_with_diabetic_nephropathy]_ DB - PRIME DP - Unbound Medicine ER -