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Prevalence of lactose malabsorption in Galicia.
J Pediatr Gastroenterol Nutr. 1997 Sep; 25(3):296-300.JP

Abstract

BACKGROUND

The aim of the current study was to evaluate the prevalence of lactose malabsorption (LM) in Galicia (NW Spain) in order to design nutritional intervention and/or public education strategies for high risk groups.

METHODS

We conducted a study of LM by breath-hydrogen carbohydrate absorption test (BH2 test) in 850 healthy subjects. All subjects underwent BH2 tests following ingestion of a aqueous solution of 2 g lactose/kg body weight up to a maximum of 50 g. Subjects with LM were retested after ingesting 250 ml of milk and/or 250 ml of yogurt.

RESULTS

The frequency of LM in the subjects who ingested 2 g lactose/kg body weight was 32.5%. This percentage decreased significantly with a decrease in the quantity of administered lactose and the vehicle was milk or yogurt-only 13.7% was LM after 250 ml of milk and 3.8% after 250 ml of yogurt. Gastrointestinal symptoms also depend on dosage of lactose and vehicle, decreasing from 54.3% after 2 g lactose/kg to 18.5% after milk and to 0% after yogurt. The frequency and number of gastrointestinal symptoms were significantly higher (p < 0.001) in LM than in lactose absorption (LA).

CONCLUSIONS

Lactose malabsorption is prevalent in the population of Galicia. An important number of subjects identified as LM with usual clinical testing become LA when the ingestion of dairy products is limited so that the amount of lactose consumed is similar to that contained in a usual serving. Our results suggest the importance of BH2 testing following ingestion of usual consumed amounts of lactose per serving.

Authors+Show Affiliations

Departamento de Pediatría, Complejo Hospitalario Universitario de Santiago, Universidad de Santiago de Compostela, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9285380

Citation

Leis, R, et al. "Prevalence of Lactose Malabsorption in Galicia." Journal of Pediatric Gastroenterology and Nutrition, vol. 25, no. 3, 1997, pp. 296-300.
Leis R, Tojo R, Pavón P, et al. Prevalence of lactose malabsorption in Galicia. J Pediatr Gastroenterol Nutr. 1997;25(3):296-300.
Leis, R., Tojo, R., Pavón, P., & Douwes, A. (1997). Prevalence of lactose malabsorption in Galicia. Journal of Pediatric Gastroenterology and Nutrition, 25(3), 296-300.
Leis R, et al. Prevalence of Lactose Malabsorption in Galicia. J Pediatr Gastroenterol Nutr. 1997;25(3):296-300. PubMed PMID: 9285380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of lactose malabsorption in Galicia. AU - Leis,R, AU - Tojo,R, AU - Pavón,P, AU - Douwes,A, PY - 1997/9/1/pubmed PY - 1997/9/1/medline PY - 1997/9/1/entrez SP - 296 EP - 300 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 25 IS - 3 N2 - BACKGROUND: The aim of the current study was to evaluate the prevalence of lactose malabsorption (LM) in Galicia (NW Spain) in order to design nutritional intervention and/or public education strategies for high risk groups. METHODS: We conducted a study of LM by breath-hydrogen carbohydrate absorption test (BH2 test) in 850 healthy subjects. All subjects underwent BH2 tests following ingestion of a aqueous solution of 2 g lactose/kg body weight up to a maximum of 50 g. Subjects with LM were retested after ingesting 250 ml of milk and/or 250 ml of yogurt. RESULTS: The frequency of LM in the subjects who ingested 2 g lactose/kg body weight was 32.5%. This percentage decreased significantly with a decrease in the quantity of administered lactose and the vehicle was milk or yogurt-only 13.7% was LM after 250 ml of milk and 3.8% after 250 ml of yogurt. Gastrointestinal symptoms also depend on dosage of lactose and vehicle, decreasing from 54.3% after 2 g lactose/kg to 18.5% after milk and to 0% after yogurt. The frequency and number of gastrointestinal symptoms were significantly higher (p < 0.001) in LM than in lactose absorption (LA). CONCLUSIONS: Lactose malabsorption is prevalent in the population of Galicia. An important number of subjects identified as LM with usual clinical testing become LA when the ingestion of dairy products is limited so that the amount of lactose consumed is similar to that contained in a usual serving. Our results suggest the importance of BH2 testing following ingestion of usual consumed amounts of lactose per serving. SN - 0277-2116 UR - https://www.unboundmedicine.com/medline/citation/9285380/Prevalence_of_lactose_malabsorption_in_Galicia_ DB - PRIME DP - Unbound Medicine ER -