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Indications for preoperative seminal vesicle biopsies in staging of clinically localized prostatic cancer.
Eur Urol. 1997; 32(2):160-5.EU

Abstract

OBJECTIVE

To identify patients at high risk of extraprostatic seminal vesicle infiltration, in whom preoperative seminal vesicle biopsies should be performed.

MATERIALS AND METHODS

We studied the relationship between extraprostatic seminal vesicle infiltration and the available preoperative data [age, clinical stage, prostate-specific antigen (PSA) level, number and site of positive prostatic sextant biopsies, Gleason score] in a total of 75 patients suffering from clinically localized prostatic adenocarcinoma who were candidates for radical prostatectomy.

RESULTS

The chi 2 test showed that the preoperative data most significantly correlated with extraprostatic seminal vesicle infiltration were the presence of positive basal biopsies (p < 0.001). The PSA level did not have any predictive value. The most discriminant preoperative parameter of the state of the seminal vesicles (analysis of variance on a univariate model) was the state of the basal prostatic biopsies. The importance of this parameter was confirmed by cluster analysis. Overall, the risk of extraprostatic seminal vesicle invasion was 0 (0/21 patients) when the 2 basal prostatic biopsies were negative, 10.25% (4/39 patients) when 1 of the 2 basal prostatic biopsies was positive and 73.33% (11/15 patients) when both basal prostatic biopsies were positive.

CONCLUSIONS

In a patient with clinically localized prostatic adenocarcinoma who is a candidate for radical prostatectomy, seminal vesicle biopsies are useless when basal prostatic biopsies are negative, regardless of the state of other preoperative parameters. When 1 or 2 basal prostatic biopsies are positive, seminal vesicle biopsies can improve the pretreatment pathological staging.

Authors+Show Affiliations

Guillonneau B
Department of Urology, Institut Mutualiste Montsouris, Paris, France.
Debras B
No affiliation info available
Veillon B
No affiliation info available
Bougaran J
No affiliation info available
Chambon E
No affiliation info available
Vallancien G
No affiliation info available

MeSH

AdenocarcinomaAgedBiopsy, NeedleHumansMaleMiddle AgedNeoplasm InvasivenessPredictive Value of TestsProstateProstate-Specific AntigenProstatectomyProstatic NeoplasmsSeminal Vesicles

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9286646

Citation

Guillonneau, B, et al. "Indications for Preoperative Seminal Vesicle Biopsies in Staging of Clinically Localized Prostatic Cancer." European Urology, vol. 32, no. 2, 1997, pp. 160-5.
Guillonneau B, Debras B, Veillon B, et al. Indications for preoperative seminal vesicle biopsies in staging of clinically localized prostatic cancer. Eur Urol. 1997;32(2):160-5.
Guillonneau, B., Debras, B., Veillon, B., Bougaran, J., Chambon, E., & Vallancien, G. (1997). Indications for preoperative seminal vesicle biopsies in staging of clinically localized prostatic cancer. European Urology, 32(2), 160-5.
Guillonneau B, et al. Indications for Preoperative Seminal Vesicle Biopsies in Staging of Clinically Localized Prostatic Cancer. Eur Urol. 1997;32(2):160-5. PubMed PMID: 9286646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Indications for preoperative seminal vesicle biopsies in staging of clinically localized prostatic cancer. AU - Guillonneau,B, AU - Debras,B, AU - Veillon,B, AU - Bougaran,J, AU - Chambon,E, AU - Vallancien,G, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 160 EP - 5 JF - European urology JO - Eur Urol VL - 32 IS - 2 N2 - OBJECTIVE: To identify patients at high risk of extraprostatic seminal vesicle infiltration, in whom preoperative seminal vesicle biopsies should be performed. MATERIALS AND METHODS: We studied the relationship between extraprostatic seminal vesicle infiltration and the available preoperative data [age, clinical stage, prostate-specific antigen (PSA) level, number and site of positive prostatic sextant biopsies, Gleason score] in a total of 75 patients suffering from clinically localized prostatic adenocarcinoma who were candidates for radical prostatectomy. RESULTS: The chi 2 test showed that the preoperative data most significantly correlated with extraprostatic seminal vesicle infiltration were the presence of positive basal biopsies (p < 0.001). The PSA level did not have any predictive value. The most discriminant preoperative parameter of the state of the seminal vesicles (analysis of variance on a univariate model) was the state of the basal prostatic biopsies. The importance of this parameter was confirmed by cluster analysis. Overall, the risk of extraprostatic seminal vesicle invasion was 0 (0/21 patients) when the 2 basal prostatic biopsies were negative, 10.25% (4/39 patients) when 1 of the 2 basal prostatic biopsies was positive and 73.33% (11/15 patients) when both basal prostatic biopsies were positive. CONCLUSIONS: In a patient with clinically localized prostatic adenocarcinoma who is a candidate for radical prostatectomy, seminal vesicle biopsies are useless when basal prostatic biopsies are negative, regardless of the state of other preoperative parameters. When 1 or 2 basal prostatic biopsies are positive, seminal vesicle biopsies can improve the pretreatment pathological staging. SN - 0302-2838 UR - https://www.unboundmedicine.com/medline/citation/9286646/Indications_for_preoperative_seminal_vesicle_biopsies_in_staging_of_clinically_localized_prostatic_cancer_ L2 - https://medlineplus.gov/prostatecancer.html DB - PRIME DP - Unbound Medicine ER -
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