Tags

Type your tag names separated by a space and hit enter

The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids.
Gastroenterology. 1997 Sep; 113(3):773-81.G

Abstract

BACKGROUND & AIMS

Both gastrin and genetic factors were suggested to underlie the pathogenesis of multiple gastric enterochromaffin-like (ECL) cell carcinoids. To assess the role of genetic alterations in carcinoid tumorigenesis, loss of heterozygosity (LOH) at the locus of the multiple endocrine neoplasia type 1 (MEN-1) gene was studied in gastric carcinoids of patients with MEN-1 and chronic atrophic type A gastritis (A-CAG), as well as in sporadically arising intestinal carcinoids.

METHODS

DNA extracted from archival tissue sections of 35 carcinoid tumors was assessed for LOH with eight polymorphic markers on chromosome 11q13. A combined tumor and family study was performed in 1 patient with MEN-1-Zollinger-Ellison syndrome (ZES).

RESULTS

LOH at 11q13 loci was detected in 15 of 20 (75%) MEN-1-ZES carcinoids, and each ECL-cell carcinoid with LOH showed deletion of the wild-type allele. Only 1 of 6 A-CAG carcinoids displayed LOH at the MEN-1 gene locus, and none of the 9 intestinal and rectal carcinoids showed 11q13 LOH.

CONCLUSIONS

Gastric ECL-cell carcinoid is an independent tumor type of MEN-1 that shares a common developmental mechanism (via inactivation of the MEN-1 gene) with enteropancreatic and parathyroid MEN-1 tumors. Further analysis of sporadic and A-CAG carcinoids is needed to elucidate genetic factors involved in their tumorigenesis.

Authors+Show Affiliations

Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9287968

Citation

Debelenko, L V., et al. "The Multiple Endocrine Neoplasia Type I Gene Locus Is Involved in the Pathogenesis of Type II Gastric Carcinoids." Gastroenterology, vol. 113, no. 3, 1997, pp. 773-81.
Debelenko LV, Emmert-Buck MR, Zhuang Z, et al. The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterology. 1997;113(3):773-81.
Debelenko, L. V., Emmert-Buck, M. R., Zhuang, Z., Epshteyn, E., Moskaluk, C. A., Jensen, R. T., Liotta, L. A., & Lubensky, I. A. (1997). The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. Gastroenterology, 113(3), 773-81.
Debelenko LV, et al. The Multiple Endocrine Neoplasia Type I Gene Locus Is Involved in the Pathogenesis of Type II Gastric Carcinoids. Gastroenterology. 1997;113(3):773-81. PubMed PMID: 9287968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The multiple endocrine neoplasia type I gene locus is involved in the pathogenesis of type II gastric carcinoids. AU - Debelenko,L V, AU - Emmert-Buck,M R, AU - Zhuang,Z, AU - Epshteyn,E, AU - Moskaluk,C A, AU - Jensen,R T, AU - Liotta,L A, AU - Lubensky,I A, PY - 1997/9/1/pubmed PY - 1997/9/1/medline PY - 1997/9/1/entrez SP - 773 EP - 81 JF - Gastroenterology JO - Gastroenterology VL - 113 IS - 3 N2 - BACKGROUND & AIMS: Both gastrin and genetic factors were suggested to underlie the pathogenesis of multiple gastric enterochromaffin-like (ECL) cell carcinoids. To assess the role of genetic alterations in carcinoid tumorigenesis, loss of heterozygosity (LOH) at the locus of the multiple endocrine neoplasia type 1 (MEN-1) gene was studied in gastric carcinoids of patients with MEN-1 and chronic atrophic type A gastritis (A-CAG), as well as in sporadically arising intestinal carcinoids. METHODS: DNA extracted from archival tissue sections of 35 carcinoid tumors was assessed for LOH with eight polymorphic markers on chromosome 11q13. A combined tumor and family study was performed in 1 patient with MEN-1-Zollinger-Ellison syndrome (ZES). RESULTS: LOH at 11q13 loci was detected in 15 of 20 (75%) MEN-1-ZES carcinoids, and each ECL-cell carcinoid with LOH showed deletion of the wild-type allele. Only 1 of 6 A-CAG carcinoids displayed LOH at the MEN-1 gene locus, and none of the 9 intestinal and rectal carcinoids showed 11q13 LOH. CONCLUSIONS: Gastric ECL-cell carcinoid is an independent tumor type of MEN-1 that shares a common developmental mechanism (via inactivation of the MEN-1 gene) with enteropancreatic and parathyroid MEN-1 tumors. Further analysis of sporadic and A-CAG carcinoids is needed to elucidate genetic factors involved in their tumorigenesis. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/9287968/The_multiple_endocrine_neoplasia_type_I_gene_locus_is_involved_in_the_pathogenesis_of_type_II_gastric_carcinoids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508597004149 DB - PRIME DP - Unbound Medicine ER -