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Bipolar depression: treatment options.
Can J Psychiatry. 1997 Aug; 42 Suppl 2:87S-91S.CJ

Abstract

OBJECTIVE

To review studies on treatments for bipolar depression and make recommendations for practising clinicians treating patients with bipolar depression.

METHOD

Studies that examined various treatments for bipolar depression were evaluated and rated for evidence of efficacy using Periodic Health Examination criteria. The rating for classification of recommendation for an intervention was made taking both the efficacy and the side effects into consideration.

RESULTS

Mood stabilizers, cyclic antidepressants, monoamine oxidase inhibitors (MAOIs), and electroconvulsive therapy (ECT) are all effective in treating bipolar depression. Almost all antidepressant treatments with the exception of mood stabilizers have been reported to induce a manic-hypomanic switch and rapid cycling.

CONCLUSIONS

Mood stabilizers, lithium in particular, are recommended as the first-line treatment. Addition of a second mood stabilizer or a cyclic antidepressant would be an appropriate next step. Newer agents such as lamotrigine offer considerable promise in treating bipolar depressed patients.

Authors+Show Affiliations

Department of Psychiatry, University of British Columbia, Vancouver. yatham@unixg.ubc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9288441

Citation

Yatham, L N., et al. "Bipolar Depression: Treatment Options." Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, vol. 42 Suppl 2, 1997, 87S-91S.
Yatham LN, Kusumakar V, Parikh SV, et al. Bipolar depression: treatment options. Can J Psychiatry. 1997;42 Suppl 2:87S-91S.
Yatham, L. N., Kusumakar, V., Parikh, S. V., Haslam, D. R., Matte, R., Sharma, V., & Kennedy, S. (1997). Bipolar depression: treatment options. Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie, 42 Suppl 2, 87S-91S.
Yatham LN, et al. Bipolar Depression: Treatment Options. Can J Psychiatry. 1997;42 Suppl 2:87S-91S. PubMed PMID: 9288441.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bipolar depression: treatment options. AU - Yatham,L N, AU - Kusumakar,V, AU - Parikh,S V, AU - Haslam,D R, AU - Matte,R, AU - Sharma,V, AU - Kennedy,S, PY - 1997/8/1/pubmed PY - 1997/8/1/medline PY - 1997/8/1/entrez SP - 87S EP - 91S JF - Canadian journal of psychiatry. Revue canadienne de psychiatrie JO - Can J Psychiatry VL - 42 Suppl 2 N2 - OBJECTIVE: To review studies on treatments for bipolar depression and make recommendations for practising clinicians treating patients with bipolar depression. METHOD: Studies that examined various treatments for bipolar depression were evaluated and rated for evidence of efficacy using Periodic Health Examination criteria. The rating for classification of recommendation for an intervention was made taking both the efficacy and the side effects into consideration. RESULTS: Mood stabilizers, cyclic antidepressants, monoamine oxidase inhibitors (MAOIs), and electroconvulsive therapy (ECT) are all effective in treating bipolar depression. Almost all antidepressant treatments with the exception of mood stabilizers have been reported to induce a manic-hypomanic switch and rapid cycling. CONCLUSIONS: Mood stabilizers, lithium in particular, are recommended as the first-line treatment. Addition of a second mood stabilizer or a cyclic antidepressant would be an appropriate next step. Newer agents such as lamotrigine offer considerable promise in treating bipolar depressed patients. SN - 0706-7437 UR - https://www.unboundmedicine.com/medline/citation/9288441/Bipolar_depression:_treatment_options_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -