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Inhibition of substance P-induced histamine release from rat peritoneal mast cells by ultraviolet light B irradiation: decreased intracellular calcium as a partial mechanism.
Clin Exp Allergy. 1997 Aug; 27(8):966-71.CE

Abstract

BACKGROUND

Ultraviolet light irradiation has been shown to suppress immunological reactions of irradiated individuals, however, less attention has been paid to the effects on neurogenic inflammation.

OBJECTIVE

We have investigated the effect of ultraviolet light B (UVB) irradiation on substance P (SP)-induced histamine release from rat mast cells.

METHODS

Rat peritoneal mast cells were treated with UVB irradiation and challenged by SP. Histamine release from the cells and intracellular calcium concentrations ([Ca2+]i) in the cells were measured.

RESULTS

UVB irradiation at doses used in the present study did not induce histamine release from mast cells. UVB irradiation at doses from 25 to 200 mJ/cm2 inhibited 10(-5) mol/L SP-induced histamine release in a dose-dependent manner. On the other hand, SP-induced increase of [Ca2+]i was inhibited by UVB irradiation only at doses of 100 and 200 mJ/cm2.

CONCLUSION

These data suggest that UVB irradiation inhibits histamine release from SP-activated rat peritoneal mast cells partially through the suppression of an increase in [Ca2+]i.

Authors+Show Affiliations

Department of Dermatology, Gunma University School of Medicine, Maebashi, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9291296

Citation

Amano, H, et al. "Inhibition of Substance P-induced Histamine Release From Rat Peritoneal Mast Cells By Ultraviolet Light B Irradiation: Decreased Intracellular Calcium as a Partial Mechanism." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 27, no. 8, 1997, pp. 966-71.
Amano H, Kurosawa M, Miyachi Y. Inhibition of substance P-induced histamine release from rat peritoneal mast cells by ultraviolet light B irradiation: decreased intracellular calcium as a partial mechanism. Clin Exp Allergy. 1997;27(8):966-71.
Amano, H., Kurosawa, M., & Miyachi, Y. (1997). Inhibition of substance P-induced histamine release from rat peritoneal mast cells by ultraviolet light B irradiation: decreased intracellular calcium as a partial mechanism. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 27(8), 966-71.
Amano H, Kurosawa M, Miyachi Y. Inhibition of Substance P-induced Histamine Release From Rat Peritoneal Mast Cells By Ultraviolet Light B Irradiation: Decreased Intracellular Calcium as a Partial Mechanism. Clin Exp Allergy. 1997;27(8):966-71. PubMed PMID: 9291296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibition of substance P-induced histamine release from rat peritoneal mast cells by ultraviolet light B irradiation: decreased intracellular calcium as a partial mechanism. AU - Amano,H, AU - Kurosawa,M, AU - Miyachi,Y, PY - 1997/8/1/pubmed PY - 1997/9/18/medline PY - 1997/8/1/entrez SP - 966 EP - 71 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin Exp Allergy VL - 27 IS - 8 N2 - BACKGROUND: Ultraviolet light irradiation has been shown to suppress immunological reactions of irradiated individuals, however, less attention has been paid to the effects on neurogenic inflammation. OBJECTIVE: We have investigated the effect of ultraviolet light B (UVB) irradiation on substance P (SP)-induced histamine release from rat mast cells. METHODS: Rat peritoneal mast cells were treated with UVB irradiation and challenged by SP. Histamine release from the cells and intracellular calcium concentrations ([Ca2+]i) in the cells were measured. RESULTS: UVB irradiation at doses used in the present study did not induce histamine release from mast cells. UVB irradiation at doses from 25 to 200 mJ/cm2 inhibited 10(-5) mol/L SP-induced histamine release in a dose-dependent manner. On the other hand, SP-induced increase of [Ca2+]i was inhibited by UVB irradiation only at doses of 100 and 200 mJ/cm2. CONCLUSION: These data suggest that UVB irradiation inhibits histamine release from SP-activated rat peritoneal mast cells partially through the suppression of an increase in [Ca2+]i. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/9291296/Inhibition_of_substance_P_induced_histamine_release_from_rat_peritoneal_mast_cells_by_ultraviolet_light_B_irradiation:_decreased_intracellular_calcium_as_a_partial_mechanism_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=1997&volume=27&issue=8&spage=966 DB - PRIME DP - Unbound Medicine ER -