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Short-term effects of dietary sodium intake on bone metabolism in postmenopausal women measured using urinary deoxypyridinoline excretion.
Br J Nutr 1997; 78(1):73-82BJ

Abstract

The influence of Na load on bone metabolism was investigated in postmenopausal women using urinary deoxypyridinoline (DPD) as a marker of bone resorption. In a cross-over study, fourteen postmenopausal women were divided into two groups of seven. A fixed diet providing 816 mg Ca/d with either 60 or 170 mmol Na/d was consumed. At the end of an 8 d period the groups switched diets for a further 8 d period. Urine was collected daily for the last 4 d of each period. There was no significant difference in DPD excretion between high-Na and low-Na diets (129 nmol/d v. 132 nmol/d; P = 0.18). There was, however, a significant relationship (P = 0.02) between the changes in DPD excretion and urinary Ca. Plasma Mg fell from 0.83 to 0.81 mmol/l on the high Na intake (P < 0.001), but there was no significant effect on plasma Ca or intact parathyroid hormone levels. It is concluded that varying dietary Na intake may affect Ca and Mg metabolism, but we were unable to demonstrate an effect on bone resorption at the levels of intake used.

Authors+Show Affiliations

Rowett Research Institute, Bucksburn, Aberdeen.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9292761

Citation

Lietz, G, et al. "Short-term Effects of Dietary Sodium Intake On Bone Metabolism in Postmenopausal Women Measured Using Urinary Deoxypyridinoline Excretion." The British Journal of Nutrition, vol. 78, no. 1, 1997, pp. 73-82.
Lietz G, Avenell A, Robins SP. Short-term effects of dietary sodium intake on bone metabolism in postmenopausal women measured using urinary deoxypyridinoline excretion. Br J Nutr. 1997;78(1):73-82.
Lietz, G., Avenell, A., & Robins, S. P. (1997). Short-term effects of dietary sodium intake on bone metabolism in postmenopausal women measured using urinary deoxypyridinoline excretion. The British Journal of Nutrition, 78(1), pp. 73-82.
Lietz G, Avenell A, Robins SP. Short-term Effects of Dietary Sodium Intake On Bone Metabolism in Postmenopausal Women Measured Using Urinary Deoxypyridinoline Excretion. Br J Nutr. 1997;78(1):73-82. PubMed PMID: 9292761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term effects of dietary sodium intake on bone metabolism in postmenopausal women measured using urinary deoxypyridinoline excretion. AU - Lietz,G, AU - Avenell,A, AU - Robins,S P, PY - 1997/7/1/pubmed PY - 1997/9/18/medline PY - 1997/7/1/entrez SP - 73 EP - 82 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 78 IS - 1 N2 - The influence of Na load on bone metabolism was investigated in postmenopausal women using urinary deoxypyridinoline (DPD) as a marker of bone resorption. In a cross-over study, fourteen postmenopausal women were divided into two groups of seven. A fixed diet providing 816 mg Ca/d with either 60 or 170 mmol Na/d was consumed. At the end of an 8 d period the groups switched diets for a further 8 d period. Urine was collected daily for the last 4 d of each period. There was no significant difference in DPD excretion between high-Na and low-Na diets (129 nmol/d v. 132 nmol/d; P = 0.18). There was, however, a significant relationship (P = 0.02) between the changes in DPD excretion and urinary Ca. Plasma Mg fell from 0.83 to 0.81 mmol/l on the high Na intake (P < 0.001), but there was no significant effect on plasma Ca or intact parathyroid hormone levels. It is concluded that varying dietary Na intake may affect Ca and Mg metabolism, but we were unable to demonstrate an effect on bone resorption at the levels of intake used. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/9292761/Short_term_effects_of_dietary_sodium_intake_on_bone_metabolism_in_postmenopausal_women_measured_using_urinary_deoxypyridinoline_excretion_ L2 - https://www.cambridge.org/core/product/identifier/S0007114597001141/type/journal_article DB - PRIME DP - Unbound Medicine ER -