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Inhibitory monoclonal antibodies to human cytochrome P450 2D6.
Biochem Pharmacol. 1997 Jul 01; 54(1):15-7.BP

Abstract

Two monoclonal antibodies (MAbs) have been isolated that bind to human P450 2D6 and inhibit 2D6 catalyzed bufuralol 1-hydroxylation by 90%. One but not both of the MAbs immunoblotted 2D6. The MAbs were highly specific to 2D6 and did not cross-react with other P450s. Inhibitory monoclonal antibodies will be useful for determining the contribution of 2D6 to the metabolism of a wide variety of 2D6 and other P450 substrates in human tissues containing multiple P450s.

Authors+Show Affiliations

Laboratory of Molecular Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, U.S.A.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9296346

Citation

Krausz, K W., et al. "Inhibitory Monoclonal Antibodies to Human Cytochrome P450 2D6." Biochemical Pharmacology, vol. 54, no. 1, 1997, pp. 15-7.
Krausz KW, Yang TJ, Gonzalez FJ, et al. Inhibitory monoclonal antibodies to human cytochrome P450 2D6. Biochem Pharmacol. 1997;54(1):15-7.
Krausz, K. W., Yang, T. J., Gonzalez, F. J., Shou, M., & Gelboin, H. V. (1997). Inhibitory monoclonal antibodies to human cytochrome P450 2D6. Biochemical Pharmacology, 54(1), 15-7.
Krausz KW, et al. Inhibitory Monoclonal Antibodies to Human Cytochrome P450 2D6. Biochem Pharmacol. 1997 Jul 1;54(1):15-7. PubMed PMID: 9296346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory monoclonal antibodies to human cytochrome P450 2D6. AU - Krausz,K W, AU - Yang,T J, AU - Gonzalez,F J, AU - Shou,M, AU - Gelboin,H V, PY - 1997/7/1/pubmed PY - 1997/9/20/medline PY - 1997/7/1/entrez SP - 15 EP - 7 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 54 IS - 1 N2 - Two monoclonal antibodies (MAbs) have been isolated that bind to human P450 2D6 and inhibit 2D6 catalyzed bufuralol 1-hydroxylation by 90%. One but not both of the MAbs immunoblotted 2D6. The MAbs were highly specific to 2D6 and did not cross-react with other P450s. Inhibitory monoclonal antibodies will be useful for determining the contribution of 2D6 to the metabolism of a wide variety of 2D6 and other P450 substrates in human tissues containing multiple P450s. SN - 0006-2952 UR - https://www.unboundmedicine.com/medline/citation/9296346/Inhibitory_monoclonal_antibodies_to_human_cytochrome_P450_2D6_ DB - PRIME DP - Unbound Medicine ER -