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Morphological analysis of hair follicles in alopecia areata.
Microsc Res Tech. 1997 Aug 15; 38(4):443-51.MR

Abstract

This study characterizes hair follicles from early alopecia areata lesions at both the light and electron microscopic levels and describes how affected hair follicles differ from normal hair growth. The study focuses on acute and active lesions where hair follicles show greatest divergence from the normal growth pattern and are most likely to display features of primary pathology. Morphologic analysis revealed regressive changes in the hair bulbs of anagen hair follicles in alopecia areata. While tissue injury did not appear to be cell type specific, pre-cortical keratinocytes and hair bulb melanocytes were primarily affected. Three distinct patterns of cell degeneration, of variable frequency, are described including "dark cell" transformation, apoptosis, and necrosis. Abnormal melanogenesis was a common finding in this study, which may explain some of the associated pigmentary anomalies seen clinically in acute alopecia areata. Tissue damage, which was not always associated with a mononuclear cell infiltrate, may explain the premature involution of suboptimal anagen hair follicles into an early resting phase in alopecia areata. Finally, scanning electron microscopic, light microscopic, and transmission electron microscopic studies describe defective cortex differentiation in characteristic "exclamation-mark" hair shafts. These hairs may result from a transient phase of cell degeneration among pre-cortical keratinocytes.

Authors+Show Affiliations

Department of Biomedical Sciences, University of Bradford, England.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9297694

Citation

Tobin, D J.. "Morphological Analysis of Hair Follicles in Alopecia Areata." Microscopy Research and Technique, vol. 38, no. 4, 1997, pp. 443-51.
Tobin DJ. Morphological analysis of hair follicles in alopecia areata. Microsc Res Tech. 1997;38(4):443-51.
Tobin, D. J. (1997). Morphological analysis of hair follicles in alopecia areata. Microscopy Research and Technique, 38(4), 443-51.
Tobin DJ. Morphological Analysis of Hair Follicles in Alopecia Areata. Microsc Res Tech. 1997 Aug 15;38(4):443-51. PubMed PMID: 9297694.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Morphological analysis of hair follicles in alopecia areata. A1 - Tobin,D J, PY - 1997/8/15/pubmed PY - 2000/6/22/medline PY - 1997/8/15/entrez SP - 443 EP - 51 JF - Microscopy research and technique JO - Microsc Res Tech VL - 38 IS - 4 N2 - This study characterizes hair follicles from early alopecia areata lesions at both the light and electron microscopic levels and describes how affected hair follicles differ from normal hair growth. The study focuses on acute and active lesions where hair follicles show greatest divergence from the normal growth pattern and are most likely to display features of primary pathology. Morphologic analysis revealed regressive changes in the hair bulbs of anagen hair follicles in alopecia areata. While tissue injury did not appear to be cell type specific, pre-cortical keratinocytes and hair bulb melanocytes were primarily affected. Three distinct patterns of cell degeneration, of variable frequency, are described including "dark cell" transformation, apoptosis, and necrosis. Abnormal melanogenesis was a common finding in this study, which may explain some of the associated pigmentary anomalies seen clinically in acute alopecia areata. Tissue damage, which was not always associated with a mononuclear cell infiltrate, may explain the premature involution of suboptimal anagen hair follicles into an early resting phase in alopecia areata. Finally, scanning electron microscopic, light microscopic, and transmission electron microscopic studies describe defective cortex differentiation in characteristic "exclamation-mark" hair shafts. These hairs may result from a transient phase of cell degeneration among pre-cortical keratinocytes. SN - 1059-910X UR - https://www.unboundmedicine.com/medline/citation/9297694/Morphological_analysis_of_hair_follicles_in_alopecia_areata_ L2 - https://doi.org/10.1002/(SICI)1097-0029(19970815)38:4<443::AID-JEMT12>3.0.CO;2-J DB - PRIME DP - Unbound Medicine ER -