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Behavioral responses to ethanol in light and moderate social drinkers following naltrexone pretreatment.
Drug Alcohol Depend. 1997 Aug 25; 47(2):109-16.DA

Abstract

The opioid antagonist naltrexone has been shown to be effective in the treatment of alcoholism, possibly by dampening the subjective effects of ethanol. However, naltrexone does not consistently attenuate the effects of ethanol in social drinkers in laboratory-based challenge studies. In the present study, 25 healthy volunteers, who were either light drinkers (mean = 3 drinks per week) or moderate drinkers (mean = 16 drinks per week), participated in six evening sessions. At each session, subjects ingested a capsule containing naltrexone (25 or 50 mg) or placebo, and 1 hr later they consumed a beverage containing ethanol (0.25 g/kg, equivalent to about two standard alcoholic drinks) or placebo. Subjects received all combinations of pretreatments and beverages. They completed self-report mood questionnaires and psychomotor tests at regular intervals. This low dose of ethanol produced modest but significant effects on self-report measures such as ratings of feeling a drug effect and of liking the drug effect. However, naltrexone (25 or 50 mg) pretreatment had no dampening effect on subjects' responses to ethanol. These results indicate that acute doses of naltrexone that are effective when administered chronically to alcoholics do not attenuate the acute effects of a low dose of ethanol in non-problem drinkers.

Authors+Show Affiliations

Department of Psychiatry, University of Chicago, IL 60637, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9298332

Citation

Doty, P, et al. "Behavioral Responses to Ethanol in Light and Moderate Social Drinkers Following Naltrexone Pretreatment." Drug and Alcohol Dependence, vol. 47, no. 2, 1997, pp. 109-16.
Doty P, Kirk JM, Cramblett MJ, et al. Behavioral responses to ethanol in light and moderate social drinkers following naltrexone pretreatment. Drug Alcohol Depend. 1997;47(2):109-16.
Doty, P., Kirk, J. M., Cramblett, M. J., & de Wit, H. (1997). Behavioral responses to ethanol in light and moderate social drinkers following naltrexone pretreatment. Drug and Alcohol Dependence, 47(2), 109-16.
Doty P, et al. Behavioral Responses to Ethanol in Light and Moderate Social Drinkers Following Naltrexone Pretreatment. Drug Alcohol Depend. 1997 Aug 25;47(2):109-16. PubMed PMID: 9298332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Behavioral responses to ethanol in light and moderate social drinkers following naltrexone pretreatment. AU - Doty,P, AU - Kirk,J M, AU - Cramblett,M J, AU - de Wit,H, PY - 1997/8/25/pubmed PY - 1997/9/23/medline PY - 1997/8/25/entrez SP - 109 EP - 16 JF - Drug and alcohol dependence JO - Drug Alcohol Depend VL - 47 IS - 2 N2 - The opioid antagonist naltrexone has been shown to be effective in the treatment of alcoholism, possibly by dampening the subjective effects of ethanol. However, naltrexone does not consistently attenuate the effects of ethanol in social drinkers in laboratory-based challenge studies. In the present study, 25 healthy volunteers, who were either light drinkers (mean = 3 drinks per week) or moderate drinkers (mean = 16 drinks per week), participated in six evening sessions. At each session, subjects ingested a capsule containing naltrexone (25 or 50 mg) or placebo, and 1 hr later they consumed a beverage containing ethanol (0.25 g/kg, equivalent to about two standard alcoholic drinks) or placebo. Subjects received all combinations of pretreatments and beverages. They completed self-report mood questionnaires and psychomotor tests at regular intervals. This low dose of ethanol produced modest but significant effects on self-report measures such as ratings of feeling a drug effect and of liking the drug effect. However, naltrexone (25 or 50 mg) pretreatment had no dampening effect on subjects' responses to ethanol. These results indicate that acute doses of naltrexone that are effective when administered chronically to alcoholics do not attenuate the acute effects of a low dose of ethanol in non-problem drinkers. SN - 0376-8716 UR - https://www.unboundmedicine.com/medline/citation/9298332/Behavioral_responses_to_ethanol_in_light_and_moderate_social_drinkers_following_naltrexone_pretreatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0376-8716(97)00094-X DB - PRIME DP - Unbound Medicine ER -