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Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis.
Rhinology. 1997 Jun; 35(2):67-73.R

Abstract

We compared the efficacy and safety of cetirizine (5 mg), pseudoephedrine retard (120 mg), and the combination of cetirizine (5 mg) with pseudoephedrine retard (120 mg), each given twice daily for two weeks to subjects with pollen-associated allergic rhinitis. The study was multicentre and of randomized, double-blind, parallel-group design. Five rhinitis symptoms were rated according to severity on a scale of 0 - 3, daily by patients and at each clinic visit by investigators. A total of 687 patients, aged 9 - 66 years (mean: 32 years) was randomised to treatment (cetirizine: 231; pseudoephedrine: 226; combination: 230). On entry, the three groups were comparable in relevant respects. The primary outcome measure was based on the five symptoms assessed by the patients over the 2-week treatment period. The combination was more effective, providing at least 20% more "comfortable days" (symptoms absent or at most mild) than cetirizine or pseudoephedrine given alone (median values: 53.3%, 30.8%, and 33.3%, respectively; p < 0.001). For nasal obstruction, the combination (mean score: 1.19) was more effective than cetirizine (mean score: 1.43; p = 0.0005), but there was little difference between the combination and pseudoephedrine (mean score: 1.22; not significant). Sneezing, rhinorrhoea, nasal and ocular pruritus were better controlled by combination (mean 4-symptom score: 0.77) than by pseudoephedrine alone (mean 4-symptom score: 1.12; p < 0.001) and also better than by cetirizine alone (mean 4-symptom score: 0.93; p < 0.001). No unexpected adverse reactions were observed. A combination of cetirizine and pseudoephedrine retard is well tolerated and superior to each given alone for moderate to severe allergic seasonal rhinitis, especially when nasal obstruction is a predominant symptom.

Authors+Show Affiliations

Centre Claude Bernard, Guilherand-Granges, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

9299654

Citation

Grosclaude, M, et al. "Cetirizine and Pseudoephedrine Retard, Given Alone or in Combination, in Patients With Seasonal Allergic Rhinitis." Rhinology, vol. 35, no. 2, 1997, pp. 67-73.
Grosclaude M, Mees K, Pinelli ME, et al. Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis. Rhinology. 1997;35(2):67-73.
Grosclaude, M., Mees, K., Pinelli, M. E., Lucas, M., & Van de Venne, H. (1997). Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis. Rhinology, 35(2), 67-73.
Grosclaude M, et al. Cetirizine and Pseudoephedrine Retard, Given Alone or in Combination, in Patients With Seasonal Allergic Rhinitis. Rhinology. 1997;35(2):67-73. PubMed PMID: 9299654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cetirizine and pseudoephedrine retard, given alone or in combination, in patients with seasonal allergic rhinitis. AU - Grosclaude,M, AU - Mees,K, AU - Pinelli,M E, AU - Lucas,M, AU - Van de Venne,H, PY - 1997/6/1/pubmed PY - 1997/9/23/medline PY - 1997/6/1/entrez SP - 67 EP - 73 JF - Rhinology JO - Rhinology VL - 35 IS - 2 N2 - We compared the efficacy and safety of cetirizine (5 mg), pseudoephedrine retard (120 mg), and the combination of cetirizine (5 mg) with pseudoephedrine retard (120 mg), each given twice daily for two weeks to subjects with pollen-associated allergic rhinitis. The study was multicentre and of randomized, double-blind, parallel-group design. Five rhinitis symptoms were rated according to severity on a scale of 0 - 3, daily by patients and at each clinic visit by investigators. A total of 687 patients, aged 9 - 66 years (mean: 32 years) was randomised to treatment (cetirizine: 231; pseudoephedrine: 226; combination: 230). On entry, the three groups were comparable in relevant respects. The primary outcome measure was based on the five symptoms assessed by the patients over the 2-week treatment period. The combination was more effective, providing at least 20% more "comfortable days" (symptoms absent or at most mild) than cetirizine or pseudoephedrine given alone (median values: 53.3%, 30.8%, and 33.3%, respectively; p < 0.001). For nasal obstruction, the combination (mean score: 1.19) was more effective than cetirizine (mean score: 1.43; p = 0.0005), but there was little difference between the combination and pseudoephedrine (mean score: 1.22; not significant). Sneezing, rhinorrhoea, nasal and ocular pruritus were better controlled by combination (mean 4-symptom score: 0.77) than by pseudoephedrine alone (mean 4-symptom score: 1.12; p < 0.001) and also better than by cetirizine alone (mean 4-symptom score: 0.93; p < 0.001). No unexpected adverse reactions were observed. A combination of cetirizine and pseudoephedrine retard is well tolerated and superior to each given alone for moderate to severe allergic seasonal rhinitis, especially when nasal obstruction is a predominant symptom. SN - 0300-0729 UR - https://www.unboundmedicine.com/medline/citation/9299654/Cetirizine_and_pseudoephedrine_retard_given_alone_or_in_combination_in_patients_with_seasonal_allergic_rhinitis_ L2 - https://www.rhinologyjournal.com/Abstract.php?id=244 DB - PRIME DP - Unbound Medicine ER -