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HIV infection in malnourished children in Harare, Zimbabwe.
East Afr Med J. 1997 Apr; 74(4):217-20.EA

Abstract

A descriptive study was undertaken to compare the pattern of socio-demographic features, nutritional profile and presenting features of HIV infected and uninfected children with malnutrition. A total of 140 children aged above 15 months admitted to the paediatric wards, Harare Hospital from December 1993 to February 1994 were studied. Sixty eight (48.6%) children were found to be HIV seropositive and 72 negative. The socio-demographic features were similar in both groups. Marasmus and marasmic kwashiorkor were predominant in the HIV infected children, whilst the majority (64%) of the children in the HIV uninfected group had kwashiorkor (p = 0.001). Pneumonia, lymphadenopathy, chronic discharging ears and oral thrush were significantly more frequent in the HIV infected than in the non HIV infected children (p < 0.01). Factors predictive of HIV infection were marasmus (OR 2.72, 95% CI 1.04-8.10), generalised lymphadenopathy (OR 2.77, 95% CI 1.16-6.64), oral thrush (OR 2.72, 95% CI 1.16-6.37) and discharging ears (OR 6.05, 95% CI 1.89-19.42) with a sensitivity of 57.6% (95% CI 45.7%-69.5%), specificity of 71.4% (95% CI 60.8% 82.0%). The high prevalence of HIV infection among the malnourished children emphasises the impact of the HIV epidemic on childhood nutritional morbidity.

Authors+Show Affiliations

Ticklay IM
Division of Paediatrics, Harare Hospital.
Nathoo KJ
No affiliation info available
Siziya S
No affiliation info available
Brady JP
No affiliation info available

MeSH

Case-Control StudiesChild Nutrition DisordersChild, PreschoolHIV InfectionsHumansInfantKwashiorkorProtein-Energy MalnutritionRisk FactorsSocioeconomic FactorsUrban HealthZimbabwe

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9299820

Clinical Trial Links

The University of Zimbabwe College of Health Science (UZ-CHS) BIRTH COHORT Study

Citation

Ticklay, I M., et al. "HIV Infection in Malnourished Children in Harare, Zimbabwe." East African Medical Journal, vol. 74, no. 4, 1997, pp. 217-20.
Ticklay IM, Nathoo KJ, Siziya S, et al. HIV infection in malnourished children in Harare, Zimbabwe. East Afr Med J. 1997;74(4):217-20.
Ticklay, I. M., Nathoo, K. J., Siziya, S., & Brady, J. P. (1997). HIV infection in malnourished children in Harare, Zimbabwe. East African Medical Journal, 74(4), 217-20.
Ticklay IM, et al. HIV Infection in Malnourished Children in Harare, Zimbabwe. East Afr Med J. 1997;74(4):217-20. PubMed PMID: 9299820.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HIV infection in malnourished children in Harare, Zimbabwe. AU - Ticklay,I M, AU - Nathoo,K J, AU - Siziya,S, AU - Brady,J P, PY - 1997/4/1/pubmed PY - 1997/9/23/medline PY - 1997/4/1/entrez KW - Acquired Immunodeficiency Syndrome KW - Africa KW - Africa South Of The Sahara KW - Age Factors KW - Biology KW - Child KW - Child Mortality KW - Demographic Factors KW - Developing Countries KW - Diseases KW - Eastern Africa KW - English Speaking Africa KW - Hiv Infections KW - Malnutrition KW - Mortality KW - Nutrition Disorders KW - Population KW - Population Characteristics KW - Population Dynamics KW - Research Methodology KW - Research Report KW - Risk Factors KW - Sampling Studies KW - Signs And Symptoms KW - Studies KW - Surveys KW - Viral Diseases KW - Youth KW - Zimbabwe SP - 217 EP - 20 JF - East African medical journal JO - East Afr Med J VL - 74 IS - 4 N2 - A descriptive study was undertaken to compare the pattern of socio-demographic features, nutritional profile and presenting features of HIV infected and uninfected children with malnutrition. A total of 140 children aged above 15 months admitted to the paediatric wards, Harare Hospital from December 1993 to February 1994 were studied. Sixty eight (48.6%) children were found to be HIV seropositive and 72 negative. The socio-demographic features were similar in both groups. Marasmus and marasmic kwashiorkor were predominant in the HIV infected children, whilst the majority (64%) of the children in the HIV uninfected group had kwashiorkor (p = 0.001). Pneumonia, lymphadenopathy, chronic discharging ears and oral thrush were significantly more frequent in the HIV infected than in the non HIV infected children (p < 0.01). Factors predictive of HIV infection were marasmus (OR 2.72, 95% CI 1.04-8.10), generalised lymphadenopathy (OR 2.77, 95% CI 1.16-6.64), oral thrush (OR 2.72, 95% CI 1.16-6.37) and discharging ears (OR 6.05, 95% CI 1.89-19.42) with a sensitivity of 57.6% (95% CI 45.7%-69.5%), specificity of 71.4% (95% CI 60.8% 82.0%). The high prevalence of HIV infection among the malnourished children emphasises the impact of the HIV epidemic on childhood nutritional morbidity. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/9299820/HIV_infection_in_malnourished_children_in_Harare_Zimbabwe_ L2 - https://ClinicalTrials.gov/search/term=9299820 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -