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Seroepidemiology of Helicobacter pylori infection and hepatitis A in a rural area: evidence against a common mode of transmission.
Gut. 1997 Aug; 41(2):164-8.Gut

Abstract

BACKGROUND AND AIMS

Recent studies have shown that the age-specific seroprevalence of H pylori infection parallels hepatitis A (HAV), suggesting similar modes of transmission. The aim of this study was to investigate the seroepidemiology of H pylori and HAV in the same setting.

PATIENTS

A sample of 705 resident subjects (273 men, age range 1-87 years, median 50) who attended the outpatient medical centre of the rural town of Cirò, Southern Italy (11,000 inhabitants) for blood testing were recruited.

METHODS

All subjects completed a structured questionnaire. A serum sample was drawn from each subject and assayed for H pylori IgG by a validated in house enzyme linked immunosorbent assay. Antibodies to HAV were determined in 466 subjects (163 men, age range 1-87 years, median 49). A measure of agreement between H pylori and HAV seropositivity, the kappa statistic, was used.

RESULTS

Overall, 446 (63%) subjects were seropositive for H pylori. Of the 466 subjects screened for both H pylori and HAV, 291 (62%) were seropositive for H pylori and 407 (87%) for HAV. Cross-tabulation of these data showed that 275 (59%) were seropositive and 43 (9%) seronegative for both H pylori and HAV, 16 (3%) were seropositive for H pylori, and 132 (28%) were seropositive for HAV (OR = 5.6, CI 3 to 10). There was a parallel, weakly correlated (r = 0.287) rise in the seroprevalence of the two infections with increasing age. However, the agreement between H pylori and HAV seropositivity was little better than chance (kappa = 0.21) and in those aged less than 20 years it was worse than chance (kappa = -0.064). Furthermore, multiple logistic regression analysis did not show any risk factor shared by both infections.

CONCLUSIONS

The correlation between H pylori and HAV reflects the age-specific seroprevalence of both infections rather than a true association. This study provides evidence against a common mode of transmission of H pylori and HAV.

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Authors+Show Affiliations

Luzza F
Dipartimento di Medicina Sperimentale, Università di R Calabria, Catanzaro, Italy.
Imeneo M
No affiliation info available
Maletta M
No affiliation info available
Paluccio G
No affiliation info available
Giancotti A
No affiliation info available
Perticone F
No affiliation info available
Focà A
No affiliation info available
Pallone F
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overAntibodies, BacterialAntibodies, ViralChildChild, PreschoolFemaleHelicobacter InfectionsHelicobacter pyloriHepatitis AHepatitis A Virus, HumanHumansInfantItalyMaleMiddle AgedPrevalenceRisk FactorsRural PopulationSeroepidemiologic StudiesSocioeconomic Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9301493

Citation

Luzza, F, et al. "Seroepidemiology of Helicobacter Pylori Infection and Hepatitis a in a Rural Area: Evidence Against a Common Mode of Transmission." Gut, vol. 41, no. 2, 1997, pp. 164-8.
Luzza F, Imeneo M, Maletta M, et al. Seroepidemiology of Helicobacter pylori infection and hepatitis A in a rural area: evidence against a common mode of transmission. Gut. 1997;41(2):164-8.
Luzza, F., Imeneo, M., Maletta, M., Paluccio, G., Giancotti, A., Perticone, F., Focà, A., & Pallone, F. (1997). Seroepidemiology of Helicobacter pylori infection and hepatitis A in a rural area: evidence against a common mode of transmission. Gut, 41(2), 164-8.
Luzza F, et al. Seroepidemiology of Helicobacter Pylori Infection and Hepatitis a in a Rural Area: Evidence Against a Common Mode of Transmission. Gut. 1997;41(2):164-8. PubMed PMID: 9301493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seroepidemiology of Helicobacter pylori infection and hepatitis A in a rural area: evidence against a common mode of transmission. AU - Luzza,F, AU - Imeneo,M, AU - Maletta,M, AU - Paluccio,G, AU - Giancotti,A, AU - Perticone,F, AU - Focà,A, AU - Pallone,F, PY - 1997/8/1/pubmed PY - 1997/9/25/medline PY - 1997/8/1/entrez SP - 164 EP - 8 JF - Gut JO - Gut VL - 41 IS - 2 N2 - BACKGROUND AND AIMS: Recent studies have shown that the age-specific seroprevalence of H pylori infection parallels hepatitis A (HAV), suggesting similar modes of transmission. The aim of this study was to investigate the seroepidemiology of H pylori and HAV in the same setting. PATIENTS: A sample of 705 resident subjects (273 men, age range 1-87 years, median 50) who attended the outpatient medical centre of the rural town of Cirò, Southern Italy (11,000 inhabitants) for blood testing were recruited. METHODS: All subjects completed a structured questionnaire. A serum sample was drawn from each subject and assayed for H pylori IgG by a validated in house enzyme linked immunosorbent assay. Antibodies to HAV were determined in 466 subjects (163 men, age range 1-87 years, median 49). A measure of agreement between H pylori and HAV seropositivity, the kappa statistic, was used. RESULTS: Overall, 446 (63%) subjects were seropositive for H pylori. Of the 466 subjects screened for both H pylori and HAV, 291 (62%) were seropositive for H pylori and 407 (87%) for HAV. Cross-tabulation of these data showed that 275 (59%) were seropositive and 43 (9%) seronegative for both H pylori and HAV, 16 (3%) were seropositive for H pylori, and 132 (28%) were seropositive for HAV (OR = 5.6, CI 3 to 10). There was a parallel, weakly correlated (r = 0.287) rise in the seroprevalence of the two infections with increasing age. However, the agreement between H pylori and HAV seropositivity was little better than chance (kappa = 0.21) and in those aged less than 20 years it was worse than chance (kappa = -0.064). Furthermore, multiple logistic regression analysis did not show any risk factor shared by both infections. CONCLUSIONS: The correlation between H pylori and HAV reflects the age-specific seroprevalence of both infections rather than a true association. This study provides evidence against a common mode of transmission of H pylori and HAV. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/9301493/Seroepidemiology_of_Helicobacter_pylori_infection_and_hepatitis_A_in_a_rural_area:_evidence_against_a_common_mode_of_transmission_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&pmid=9301493 DB - PRIME DP - Unbound Medicine ER -