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Increasing butyrate concentration in the distal colon by accelerating intestinal transit.
Gut. 1997 Aug; 41(2):245-51.Gut

Abstract

BACKGROUND

Populations at low risk of colonic cancer consume large amounts of fibre and starch and pass acid, bulky stools. One short chain fatty acid (SCFA), butyrate, is the colon's main energy source and inhibits malignant transformation in vitro.

AIM

To test the hypothesis that altering colonic transit rate alters colonic pH and the SCFA content of the stools.

PATIENTS

Thirteen healthy adults recruited by advertisement.

METHODS

Volunteers consumed, in turn, wheat bran, senna and loperamide, each for nine days with a two week washout period between study periods, dietary intake being unchanged. Before, and in the last four days of each intervention, whole gut transit time (WGTT), defaecation frequency, stool form, stool beta-glucuronidase activity, stool pH, stool SCFA concentrations and intracolonic pH (using a radiotelemetry capsule for continuous monitoring) were assessed.

RESULTS

WGTT decreased, stool, output and frequency increased with wheat bran and senna, vice versa with loperamide. The pH was similar in the distal colon and stool. Distal colonic pH fell with wheat bran and senna and tended to increase with loperamide. Faecal SCFA concentrations, including butyrate, increased with senna and fell with loperamide. With wheat bran the changes were non-significant, possibly because of the short duration of the study. Baseline WGTT correlated with faecal SCFA concentration (r = -0.511, p = 0.001), with faecal butyrate (r = -0.577, p < 0.001) and with distal colonic pH (r = 0.359, p = 0.029).

CONCLUSION

Bowel transit rate is a determinant of stool SCFA concentration including butyrate and distal colonic pH. This may explain the inter-relations between colonic cancer, dietary fibre intake, stool output, and stool pH.

Authors+Show Affiliations

University Department of Medicine, Bristol Royal Infirmary, UK.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

9301506

Citation

Lewis, S J., and K W. Heaton. "Increasing Butyrate Concentration in the Distal Colon By Accelerating Intestinal Transit." Gut, vol. 41, no. 2, 1997, pp. 245-51.
Lewis SJ, Heaton KW. Increasing butyrate concentration in the distal colon by accelerating intestinal transit. Gut. 1997;41(2):245-51.
Lewis, S. J., & Heaton, K. W. (1997). Increasing butyrate concentration in the distal colon by accelerating intestinal transit. Gut, 41(2), 245-51.
Lewis SJ, Heaton KW. Increasing Butyrate Concentration in the Distal Colon By Accelerating Intestinal Transit. Gut. 1997;41(2):245-51. PubMed PMID: 9301506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increasing butyrate concentration in the distal colon by accelerating intestinal transit. AU - Lewis,S J, AU - Heaton,K W, PY - 1997/8/1/pubmed PY - 1997/9/25/medline PY - 1997/8/1/entrez SP - 245 EP - 51 JF - Gut JO - Gut VL - 41 IS - 2 N2 - BACKGROUND: Populations at low risk of colonic cancer consume large amounts of fibre and starch and pass acid, bulky stools. One short chain fatty acid (SCFA), butyrate, is the colon's main energy source and inhibits malignant transformation in vitro. AIM: To test the hypothesis that altering colonic transit rate alters colonic pH and the SCFA content of the stools. PATIENTS: Thirteen healthy adults recruited by advertisement. METHODS: Volunteers consumed, in turn, wheat bran, senna and loperamide, each for nine days with a two week washout period between study periods, dietary intake being unchanged. Before, and in the last four days of each intervention, whole gut transit time (WGTT), defaecation frequency, stool form, stool beta-glucuronidase activity, stool pH, stool SCFA concentrations and intracolonic pH (using a radiotelemetry capsule for continuous monitoring) were assessed. RESULTS: WGTT decreased, stool, output and frequency increased with wheat bran and senna, vice versa with loperamide. The pH was similar in the distal colon and stool. Distal colonic pH fell with wheat bran and senna and tended to increase with loperamide. Faecal SCFA concentrations, including butyrate, increased with senna and fell with loperamide. With wheat bran the changes were non-significant, possibly because of the short duration of the study. Baseline WGTT correlated with faecal SCFA concentration (r = -0.511, p = 0.001), with faecal butyrate (r = -0.577, p < 0.001) and with distal colonic pH (r = 0.359, p = 0.029). CONCLUSION: Bowel transit rate is a determinant of stool SCFA concentration including butyrate and distal colonic pH. This may explain the inter-relations between colonic cancer, dietary fibre intake, stool output, and stool pH. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/9301506/Increasing_butyrate_concentration_in_the_distal_colon_by_accelerating_intestinal_transit_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&amp;pmid=9301506 DB - PRIME DP - Unbound Medicine ER -