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Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome.
Clin Endocrinol (Oxf). 1997 Jul; 47(1):93-9.CE

Abstract

OBJECTIVE

Polycystic ovary syndrome (PCOS) is a common endocrinopathy of unknown aetiology. The aims of this study were to identify whether ovarian thecal cell steroidogenesis is abnormally regulated in PCOS by measuring steroid responses to a single dose of hCG before, and during, suppression of endogenous LH levels by GnRH analogue (GnRHa).

DESIGN

Serum levels of LH, FSH, 17 alpha hydroxyprogesterone (17OHP), androstenedione, testosterone and dehydroepiandrosterone sulphate were measured before, and 48 hours after, a single intramuscular injection of 10,000 IU hCG. The test was repeated 4 weeks after suppression of endogenous LH levels by GnRHa.

PATIENTS

The ovarian responses to hCG were compared in three groups of women. Eleven women had normal ovaries and regular cycles, eight had polycystic ovaries but not clinical features of the syndrome (PCO group) and eight had polycystic ovaries, anovulation and either severe hirsutism or alopecia (PCOS group).

RESULTS

Before GnRHa treatment, LH levels were significantly higher in the PCOS group but hCG stimulated a similar rise in 17OHP in all three groups. Following analogue, LH levels were suppressed in all three groups but the 17OHP responses to hCG were significantly higher in both the PCO and PCOS groups compared with normal controls.

CONCLUSIONS

These findings provide further evidence in favour of an intrinsic abnormality of thecal cell steroidogenesis in the polycystic ovary.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's Hospital, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9302378

Citation

Gilling-Smith, C, et al. "Evidence for a Primary Abnormality of Thecal Cell Steroidogenesis in the Polycystic Ovary Syndrome." Clinical Endocrinology, vol. 47, no. 1, 1997, pp. 93-9.
Gilling-Smith C, Story H, Rogers V, et al. Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin Endocrinol (Oxf). 1997;47(1):93-9.
Gilling-Smith, C., Story, H., Rogers, V., & Franks, S. (1997). Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clinical Endocrinology, 47(1), 93-9.
Gilling-Smith C, et al. Evidence for a Primary Abnormality of Thecal Cell Steroidogenesis in the Polycystic Ovary Syndrome. Clin Endocrinol (Oxf). 1997;47(1):93-9. PubMed PMID: 9302378.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. AU - Gilling-Smith,C, AU - Story,H, AU - Rogers,V, AU - Franks,S, PY - 1997/7/1/pubmed PY - 1997/9/26/medline PY - 1997/7/1/entrez SP - 93 EP - 9 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 47 IS - 1 N2 - OBJECTIVE: Polycystic ovary syndrome (PCOS) is a common endocrinopathy of unknown aetiology. The aims of this study were to identify whether ovarian thecal cell steroidogenesis is abnormally regulated in PCOS by measuring steroid responses to a single dose of hCG before, and during, suppression of endogenous LH levels by GnRH analogue (GnRHa). DESIGN: Serum levels of LH, FSH, 17 alpha hydroxyprogesterone (17OHP), androstenedione, testosterone and dehydroepiandrosterone sulphate were measured before, and 48 hours after, a single intramuscular injection of 10,000 IU hCG. The test was repeated 4 weeks after suppression of endogenous LH levels by GnRHa. PATIENTS: The ovarian responses to hCG were compared in three groups of women. Eleven women had normal ovaries and regular cycles, eight had polycystic ovaries but not clinical features of the syndrome (PCO group) and eight had polycystic ovaries, anovulation and either severe hirsutism or alopecia (PCOS group). RESULTS: Before GnRHa treatment, LH levels were significantly higher in the PCOS group but hCG stimulated a similar rise in 17OHP in all three groups. Following analogue, LH levels were suppressed in all three groups but the 17OHP responses to hCG were significantly higher in both the PCO and PCOS groups compared with normal controls. CONCLUSIONS: These findings provide further evidence in favour of an intrinsic abnormality of thecal cell steroidogenesis in the polycystic ovary. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/9302378/Evidence_for_a_primary_abnormality_of_thecal_cell_steroidogenesis_in_the_polycystic_ovary_syndrome_ DB - PRIME DP - Unbound Medicine ER -