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[Clinical and neuropathological aspects of Wernicke-Korsakoff syndrome].
Rev Saude Publica. 1996 Dec; 30(6):602-8.RS

Abstract

Alcohol abuse is one of most serious problems in public health and the Wernicke-Korsakoff syndrome one of the gravest consequences of alcoholism. The pathology is often undiagnosed in its less evident presentations, therefore an accurate diagnostic approach is a critical step in planning treatment. Besides new pharmacological proposals, treatment is based on the restoration of thiamine, although this is insufficient to prevent the psychological decline of a great number of patients. The cognitive impact of the pathology is derived from the interaction of alcoholic neurotoxicity, thiamine deficiency and personal susceptibility. In this article the history, epidemiology, clinical and neuropathological features of the Wernicke-Korsakoff syndrome, as well as some aspects of its treatment and prognosis, are described.

Authors+Show Affiliations

Zubaran C
Departamento de Bioquímica da Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Fernandes J
No affiliation info available
Martins F
No affiliation info available
Souza J
No affiliation info available
Machado R
No affiliation info available
Cadore M
No affiliation info available

MeSH

Alcohol Amnestic DisorderAnimalsCognition DisordersHumansPrognosisRatsSyndromeThiamineWernicke Encephalopathy

Pub Type(s)

English Abstract
Journal Article

Language

por

PubMed ID

9302831

Citation

Zubaran, C, et al. "[Clinical and Neuropathological Aspects of Wernicke-Korsakoff Syndrome]." Revista De Saude Publica, vol. 30, no. 6, 1996, pp. 602-8.
Zubaran C, Fernandes J, Martins F, et al. [Clinical and neuropathological aspects of Wernicke-Korsakoff syndrome]. Rev Saude Publica. 1996;30(6):602-8.
Zubaran, C., Fernandes, J., Martins, F., Souza, J., Machado, R., & Cadore, M. (1996). [Clinical and neuropathological aspects of Wernicke-Korsakoff syndrome]. Revista De Saude Publica, 30(6), 602-8.
Zubaran C, et al. [Clinical and Neuropathological Aspects of Wernicke-Korsakoff Syndrome]. Rev Saude Publica. 1996;30(6):602-8. PubMed PMID: 9302831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinical and neuropathological aspects of Wernicke-Korsakoff syndrome]. AU - Zubaran,C, AU - Fernandes,J, AU - Martins,F, AU - Souza,J, AU - Machado,R, AU - Cadore,M, PY - 1996/12/1/pubmed PY - 1997/9/26/medline PY - 1996/12/1/entrez SP - 602 EP - 8 JF - Revista de saude publica JO - Rev Saude Publica VL - 30 IS - 6 N2 - Alcohol abuse is one of most serious problems in public health and the Wernicke-Korsakoff syndrome one of the gravest consequences of alcoholism. The pathology is often undiagnosed in its less evident presentations, therefore an accurate diagnostic approach is a critical step in planning treatment. Besides new pharmacological proposals, treatment is based on the restoration of thiamine, although this is insufficient to prevent the psychological decline of a great number of patients. The cognitive impact of the pathology is derived from the interaction of alcoholic neurotoxicity, thiamine deficiency and personal susceptibility. In this article the history, epidemiology, clinical and neuropathological features of the Wernicke-Korsakoff syndrome, as well as some aspects of its treatment and prognosis, are described. SN - 0034-8910 UR - https://www.unboundmedicine.com/medline/citation/9302831/[Clinical_and_neuropathological_aspects_of_Wernicke_Korsakoff_syndrome]_ L2 - http://www.diseaseinfosearch.org/result/7472 DB - PRIME DP - Unbound Medicine ER -