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[Our experience in treating vulvar lichen sclerosus].
Minerva Ginecol. 1997 May; 49(5):207-12.MG

Abstract

METHODS

The authors looking for a better treatment of vulvar lichen sclerosus, treated 10 patients by topical application of clobetasol propionate (twice a day for 45 days and once a day for additional 45 days). Before and after therapy changes of subjective symptoms were studied with Vaona algometer as well as the histological modifications found in the biopsies of lesions like atrophy, hyperkeratosis, inflammatory infiltration, sclerosis, hyalinization and edema.

RESULTS

The results seem to confirm the good improvement of subjective symptoms for the itching and also for burning. The histological results were encouraging, in fact we noticed a marked reduction of inflammatory infiltration and an improvement of atrophy, hyperkeratosis, hyalinization and edema.

CONCLUSIONS

The clinical and histological results seem to confirm the therapeutic effect of the use of clobetasol propionate for the treatment of vulvar lichen sclerosus.

Authors+Show Affiliations

Cattani P
Clinica Ostetrica e Ginecologica A, Università degli Studi, Verona.
Manfrin E
No affiliation info available
Presti F
No affiliation info available
Sartori R
No affiliation info available
Buffo L
No affiliation info available

MeSH

Administration, TopicalAgedAged, 80 and overAnti-Inflammatory AgentsBiopsyClobetasolDrug EvaluationFemaleGlucocorticoidsHumansLichen Sclerosus et AtrophicusMiddle AgedRemission InductionTime FactorsVulvaVulvar Diseases

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

9304081

Citation

Cattani, P, et al. "[Our Experience in Treating Vulvar Lichen Sclerosus]." Minerva Ginecologica, vol. 49, no. 5, 1997, pp. 207-12.
Cattani P, Manfrin E, Presti F, et al. [Our experience in treating vulvar lichen sclerosus]. Minerva Ginecol. 1997;49(5):207-12.
Cattani, P., Manfrin, E., Presti, F., Sartori, R., & Buffo, L. (1997). [Our experience in treating vulvar lichen sclerosus]. Minerva Ginecologica, 49(5), 207-12.
Cattani P, et al. [Our Experience in Treating Vulvar Lichen Sclerosus]. Minerva Ginecol. 1997;49(5):207-12. PubMed PMID: 9304081.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Our experience in treating vulvar lichen sclerosus]. AU - Cattani,P, AU - Manfrin,E, AU - Presti,F, AU - Sartori,R, AU - Buffo,L, PY - 1997/5/1/pubmed PY - 1997/9/26/medline PY - 1997/5/1/entrez SP - 207 EP - 12 JF - Minerva ginecologica JO - Minerva Ginecol VL - 49 IS - 5 N2 - METHODS: The authors looking for a better treatment of vulvar lichen sclerosus, treated 10 patients by topical application of clobetasol propionate (twice a day for 45 days and once a day for additional 45 days). Before and after therapy changes of subjective symptoms were studied with Vaona algometer as well as the histological modifications found in the biopsies of lesions like atrophy, hyperkeratosis, inflammatory infiltration, sclerosis, hyalinization and edema. RESULTS: The results seem to confirm the good improvement of subjective symptoms for the itching and also for burning. The histological results were encouraging, in fact we noticed a marked reduction of inflammatory infiltration and an improvement of atrophy, hyperkeratosis, hyalinization and edema. CONCLUSIONS: The clinical and histological results seem to confirm the therapeutic effect of the use of clobetasol propionate for the treatment of vulvar lichen sclerosus. SN - 0026-4784 UR - https://www.unboundmedicine.com/medline/citation/9304081/[Our_experience_in_treating_vulvar_lichen_sclerosus]_ DB - PRIME DP - Unbound Medicine ER -