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Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants.
Eur J Clin Nutr 1997; 51(9):578-84EJ

Abstract

OBJECTIVES

To determine the effect of increasing docosahexaenoic acid (DHA, 22:6 n-3) in breast milk on infant fatty acid profiles. A secondary aim was to examine aspects of neural development.

DESIGN AND SETTING

Double blind, placebo controlled study of infants recruited from postnatal wards at Flinders Medical Centre.

SUBJECTS

Fifty-two healthy term infants who were breast fed for at least 12 weeks and were from middle class families.

INTERVENTION

Breast milk with DHA concentrations that ranged from 0.1-1.7% of total fatty acids. This was achieved by supplementation of the maternal diet for the first 12 weeks post partum.

RESULTS

Breast milk with DHA was related to infant plasma (r = 0.89, P < 0.001) and erythrocyte (r = 88, P < 0.001) phospholipids in a saturable curvilinear manner so that breast milk DHA above 0.8% of total fatty acids resulted in little further increase in infant plasma or erythrocyte DHA levels. The rise in plasma and erythrocyte DHA was approximated by a fall in total n-6 polyunsaturated fatty acids. We could detect no relationship between visual evoked potential acuity (measured at 12 and 16 weeks) of infants by either the dietary grouping or the DHA status of individuals. A stepwise multiple regression showed that infant erythrocyte DHA at 12 weeks and home stimulation were the only independent factors associated with Bayley's MDI at 1 y (adjusted model r2 = 0.18, P < 0.005); while at 2 y gender and social score of the spouse were the only significant predictors of Bayley's MDI (adjusted model r2 = 0.22, P < 0.005).

CONCLUSIONS

Increasing breast milk DHA levels caused a dose dependent saturable increase in infant plasma and erythrocyte phospholipid DHA. There were no long-term effects of infant DHA status on indices of neurodevelopment.

Authors+Show Affiliations

Department of Paediatrics & Child Health, Flinders Medical Centre, Adelaide, SA, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9306083

Citation

Gibson, R A., et al. "Effect of Increasing Breast Milk Docosahexaenoic Acid On Plasma and Erythrocyte Phospholipid Fatty Acids and Neural Indices of Exclusively Breast Fed Infants." European Journal of Clinical Nutrition, vol. 51, no. 9, 1997, pp. 578-84.
Gibson RA, Neumann MA, Makrides M. Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. Eur J Clin Nutr. 1997;51(9):578-84.
Gibson, R. A., Neumann, M. A., & Makrides, M. (1997). Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. European Journal of Clinical Nutrition, 51(9), pp. 578-84.
Gibson RA, Neumann MA, Makrides M. Effect of Increasing Breast Milk Docosahexaenoic Acid On Plasma and Erythrocyte Phospholipid Fatty Acids and Neural Indices of Exclusively Breast Fed Infants. Eur J Clin Nutr. 1997;51(9):578-84. PubMed PMID: 9306083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of increasing breast milk docosahexaenoic acid on plasma and erythrocyte phospholipid fatty acids and neural indices of exclusively breast fed infants. AU - Gibson,R A, AU - Neumann,M A, AU - Makrides,M, PY - 1997/11/5/pubmed PY - 1997/11/5/medline PY - 1997/11/5/entrez SP - 578 EP - 84 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 51 IS - 9 N2 - OBJECTIVES: To determine the effect of increasing docosahexaenoic acid (DHA, 22:6 n-3) in breast milk on infant fatty acid profiles. A secondary aim was to examine aspects of neural development. DESIGN AND SETTING: Double blind, placebo controlled study of infants recruited from postnatal wards at Flinders Medical Centre. SUBJECTS: Fifty-two healthy term infants who were breast fed for at least 12 weeks and were from middle class families. INTERVENTION: Breast milk with DHA concentrations that ranged from 0.1-1.7% of total fatty acids. This was achieved by supplementation of the maternal diet for the first 12 weeks post partum. RESULTS: Breast milk with DHA was related to infant plasma (r = 0.89, P < 0.001) and erythrocyte (r = 88, P < 0.001) phospholipids in a saturable curvilinear manner so that breast milk DHA above 0.8% of total fatty acids resulted in little further increase in infant plasma or erythrocyte DHA levels. The rise in plasma and erythrocyte DHA was approximated by a fall in total n-6 polyunsaturated fatty acids. We could detect no relationship between visual evoked potential acuity (measured at 12 and 16 weeks) of infants by either the dietary grouping or the DHA status of individuals. A stepwise multiple regression showed that infant erythrocyte DHA at 12 weeks and home stimulation were the only independent factors associated with Bayley's MDI at 1 y (adjusted model r2 = 0.18, P < 0.005); while at 2 y gender and social score of the spouse were the only significant predictors of Bayley's MDI (adjusted model r2 = 0.22, P < 0.005). CONCLUSIONS: Increasing breast milk DHA levels caused a dose dependent saturable increase in infant plasma and erythrocyte phospholipid DHA. There were no long-term effects of infant DHA status on indices of neurodevelopment. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/9306083/Effect_of_increasing_breast_milk_docosahexaenoic_acid_on_plasma_and_erythrocyte_phospholipid_fatty_acids_and_neural_indices_of_exclusively_breast_fed_infants_ L2 - https://ClinicalTrials.gov/search/term=9306083 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -