Tags

Type your tag names separated by a space and hit enter

Hair concentrations and self-reported abuse history of 20 amphetamine and ecstasy users.
Forensic Sci Int. 1997 Sep 19; 89(1-2):111-28.FS

Abstract

Hair samples of 20 volunteers of the techno-music scene, who more or less regularly consumed ecstasy tablets and speed and anonymously reported their abuse history, were analyzed in one to seven 3 cm segments for amphetamine (A), methamphetamine (MA), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), methylenedioxyethamphetamine (MDE) and N-methyl-1-(1,3-benzodioxol-5-yl)-2-butylamine (MBDB) by digestion in 1 M NaOH, subsequent extraction with C18 Bond Elut columns, derivatization with pentafluoropropionyl anhydride and GC/MS-SIM measurements using deuterated standards of A, MA, MDA and MDMA. The concentrations were in the regions 0.1 to 4.8 ng/mg for A (17 samples), 0.05 to 0.89 ng/mg for MDA (16 samples), 0.1 to 8.3 ng/mg for MDMA (16 samples), 0.12 to 15 ng/mg for MDE (13 samples) and 0.21 to 1.3 ng/mg for MBDB (2 samples). MA was not detected. For comparison the frequency and the concentration of these drugs in 124 different ecstasy tablets were determined by HPLC. The drug concentration in the hair segments were compared with the volunteers' reports. Despite the enormous interindividual differences qualitatively an increase of the total concentration of MDA, MDMA and MDE in the proximate 3 cm segments with increasing ecstasy abuse frequency during the last three month before sampling is recognized. In the individual comparison with the chronological consumer reports in most cases a longer interruption or a change of the abuse intensity is not clearly seen at the segment concentrations. As a reason the incorporation of the drugs from sweat into elder hair regions and the slow removal by washing are discussed.

Authors+Show Affiliations

Institute of Forensic Medicine, Humboldt-University, Berlin, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9306670

Citation

Rothe, M, et al. "Hair Concentrations and Self-reported Abuse History of 20 Amphetamine and Ecstasy Users." Forensic Science International, vol. 89, no. 1-2, 1997, pp. 111-28.
Rothe M, Pragst F, Spiegel K, et al. Hair concentrations and self-reported abuse history of 20 amphetamine and ecstasy users. Forensic Sci Int. 1997;89(1-2):111-28.
Rothe, M., Pragst, F., Spiegel, K., Harrach, T., Fischer, K., & Kunkel, J. (1997). Hair concentrations and self-reported abuse history of 20 amphetamine and ecstasy users. Forensic Science International, 89(1-2), 111-28.
Rothe M, et al. Hair Concentrations and Self-reported Abuse History of 20 Amphetamine and Ecstasy Users. Forensic Sci Int. 1997 Sep 19;89(1-2):111-28. PubMed PMID: 9306670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hair concentrations and self-reported abuse history of 20 amphetamine and ecstasy users. AU - Rothe,M, AU - Pragst,F, AU - Spiegel,K, AU - Harrach,T, AU - Fischer,K, AU - Kunkel,J, PY - 1997/10/27/pubmed PY - 1997/10/27/medline PY - 1997/10/27/entrez SP - 111 EP - 28 JF - Forensic science international JO - Forensic Sci Int VL - 89 IS - 1-2 N2 - Hair samples of 20 volunteers of the techno-music scene, who more or less regularly consumed ecstasy tablets and speed and anonymously reported their abuse history, were analyzed in one to seven 3 cm segments for amphetamine (A), methamphetamine (MA), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), methylenedioxyethamphetamine (MDE) and N-methyl-1-(1,3-benzodioxol-5-yl)-2-butylamine (MBDB) by digestion in 1 M NaOH, subsequent extraction with C18 Bond Elut columns, derivatization with pentafluoropropionyl anhydride and GC/MS-SIM measurements using deuterated standards of A, MA, MDA and MDMA. The concentrations were in the regions 0.1 to 4.8 ng/mg for A (17 samples), 0.05 to 0.89 ng/mg for MDA (16 samples), 0.1 to 8.3 ng/mg for MDMA (16 samples), 0.12 to 15 ng/mg for MDE (13 samples) and 0.21 to 1.3 ng/mg for MBDB (2 samples). MA was not detected. For comparison the frequency and the concentration of these drugs in 124 different ecstasy tablets were determined by HPLC. The drug concentration in the hair segments were compared with the volunteers' reports. Despite the enormous interindividual differences qualitatively an increase of the total concentration of MDA, MDMA and MDE in the proximate 3 cm segments with increasing ecstasy abuse frequency during the last three month before sampling is recognized. In the individual comparison with the chronological consumer reports in most cases a longer interruption or a change of the abuse intensity is not clearly seen at the segment concentrations. As a reason the incorporation of the drugs from sweat into elder hair regions and the slow removal by washing are discussed. SN - 0379-0738 UR - https://www.unboundmedicine.com/medline/citation/9306670/Hair_concentrations_and_self_reported_abuse_history_of_20_amphetamine_and_ecstasy_users_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(97)00123-0 DB - PRIME DP - Unbound Medicine ER -