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Energy expenditure, substrate oxidation, and body composition in subjects with chronic alcoholism: new findings from metabolic assessment.

Abstract

There is some controversy as to the effect of ethanol on body weight and alcohol energy contribution to body mass. The aim of this study was to evaluate the effect of alcohol addiction on resting energy expenditure (REE) and body composition. Twelve patients with current alcoholism (A) without severe liver disease or lipid and carbohydrate malabsorption were compared with a group of healthy social drinkers (B) matched for sex, age, and height. Their caloric intake was computed on the basis of a food diary. REE was measured with indirect calorimetry, and body composition was assessed by both anthropometry and bioimpedance. A significant decrease in fat mass in A compared with B was found (14.8 +/- 5.39 vs. 19.0 +/- 3.50 kg; p < 0.05). No significant differences were observed in fat-free mass (FFM) or in total body water between the two groups. A showed higher REE values normalized by FFM than B (35.5 +/- 2.97 vs. 33.0 +/- 2.95 kcal/kgFFM; p < 0.05). The nonprotein respiratory quotient was significantly lower in A than in B (0.76 +/- 0.03 vs. 0.86 +/- 0.03; p < 0.001), and A showed significantly higher lipid oxidation and lower carbohydrate oxidation than B (p < 0.05). The daily caloric intake provided only by food ingestion was found to be significantly higher in controls, but because the percentage of alcohol calories of total energy intake was 46.3 +/- 6.80 in alcoholics and 13.6 +/- 3.59 in controls (p < 0.0001), the total caloric intake, computed as food intake plus alcohol intake, was higher in alcoholics than in control subjects. No statistical differences were found in urinary nitrogen excretion and fecal loss between groups. Patients with alcoholism showed an increased REE over predicted values and a preferential lipid oxidation with respect to controls; these findings could be related to induction of microsomal ethanol oxidizing system and to mitochondrial function adaptation secondary to chronic alcohol abuse. In either case, the effects of such changes in energy metabolism may contribute to alcohol associated hepatic injury.

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  • Authors+Show Affiliations

    ,

    Institute of Internal Medicine, Università Cattolica, Rome, Italy.

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    Source

    MeSH

    Adult
    Alcoholism
    Body Composition
    Calorimetry, Indirect
    Dietary Carbohydrates
    Dietary Fats
    Energy Intake
    Energy Metabolism
    Ethanol
    Female
    Humans
    Lipid Metabolism
    Male
    Middle Aged
    Reference Values

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9309302

    Citation

    Addolorato, G, et al. "Energy Expenditure, Substrate Oxidation, and Body Composition in Subjects With Chronic Alcoholism: New Findings From Metabolic Assessment." Alcoholism, Clinical and Experimental Research, vol. 21, no. 6, 1997, pp. 962-7.
    Addolorato G, Capristo E, Greco AV, et al. Energy expenditure, substrate oxidation, and body composition in subjects with chronic alcoholism: new findings from metabolic assessment. Alcohol Clin Exp Res. 1997;21(6):962-7.
    Addolorato, G., Capristo, E., Greco, A. V., Stefanini, G. F., & Gasbarrini, G. (1997). Energy expenditure, substrate oxidation, and body composition in subjects with chronic alcoholism: new findings from metabolic assessment. Alcoholism, Clinical and Experimental Research, 21(6), pp. 962-7.
    Addolorato G, et al. Energy Expenditure, Substrate Oxidation, and Body Composition in Subjects With Chronic Alcoholism: New Findings From Metabolic Assessment. Alcohol Clin Exp Res. 1997;21(6):962-7. PubMed PMID: 9309302.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Energy expenditure, substrate oxidation, and body composition in subjects with chronic alcoholism: new findings from metabolic assessment. AU - Addolorato,G, AU - Capristo,E, AU - Greco,A V, AU - Stefanini,G F, AU - Gasbarrini,G, PY - 1997/10/6/pubmed PY - 1997/10/6/medline PY - 1997/10/6/entrez SP - 962 EP - 7 JF - Alcoholism, clinical and experimental research JO - Alcohol. Clin. Exp. Res. VL - 21 IS - 6 N2 - There is some controversy as to the effect of ethanol on body weight and alcohol energy contribution to body mass. The aim of this study was to evaluate the effect of alcohol addiction on resting energy expenditure (REE) and body composition. Twelve patients with current alcoholism (A) without severe liver disease or lipid and carbohydrate malabsorption were compared with a group of healthy social drinkers (B) matched for sex, age, and height. Their caloric intake was computed on the basis of a food diary. REE was measured with indirect calorimetry, and body composition was assessed by both anthropometry and bioimpedance. A significant decrease in fat mass in A compared with B was found (14.8 +/- 5.39 vs. 19.0 +/- 3.50 kg; p < 0.05). No significant differences were observed in fat-free mass (FFM) or in total body water between the two groups. A showed higher REE values normalized by FFM than B (35.5 +/- 2.97 vs. 33.0 +/- 2.95 kcal/kgFFM; p < 0.05). The nonprotein respiratory quotient was significantly lower in A than in B (0.76 +/- 0.03 vs. 0.86 +/- 0.03; p < 0.001), and A showed significantly higher lipid oxidation and lower carbohydrate oxidation than B (p < 0.05). The daily caloric intake provided only by food ingestion was found to be significantly higher in controls, but because the percentage of alcohol calories of total energy intake was 46.3 +/- 6.80 in alcoholics and 13.6 +/- 3.59 in controls (p < 0.0001), the total caloric intake, computed as food intake plus alcohol intake, was higher in alcoholics than in control subjects. No statistical differences were found in urinary nitrogen excretion and fecal loss between groups. Patients with alcoholism showed an increased REE over predicted values and a preferential lipid oxidation with respect to controls; these findings could be related to induction of microsomal ethanol oxidizing system and to mitochondrial function adaptation secondary to chronic alcohol abuse. In either case, the effects of such changes in energy metabolism may contribute to alcohol associated hepatic injury. SN - 0145-6008 UR - https://www.unboundmedicine.com/medline/citation/9309302/Energy_expenditure_substrate_oxidation_and_body_composition_in_subjects_with_chronic_alcoholism:_new_findings_from_metabolic_assessment_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0145-6008&amp;date=1997&amp;volume=21&amp;issue=6&amp;spage=962 DB - PRIME DP - Unbound Medicine ER -