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Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.
Int J Geriatr Psychiatry. 1997 Sep; 12(9):913-9.IJ

Abstract

A placebo-controlled crossover design, with each treatment period lasting 6 weeks, was used to investigate effects of dronabinol in 15 patients with a diagnosis of probable Alzhemer's disease who were refusing food. Eleven patients completed both study periods; one patient who died of a heart attack 2 weeks before the end of the study was also included in the analysis. The study was terminated in 3 patients: one developed a grand mal seizure and 2 developed serious intercurrent infections. Body weight of study subjects increased more during the dronabinol treatment than during the placebo periods. Dronabinol treatment decreased severity of disturbed behavior and this effect persisted during the placebo period in patients who received dronabinol first. Adverse reactions observed more commonly during the dronabinol treatment than during placebo periods included euphoria, somnolence and tiredness, but did not require discontinuation of therapy. These results indicate that dronabinol is a promising novel therapeutic agent which may be useful not only for treatment of anorexia but also to improve disturbed behavior in patients with Alzheimer's disease.

Authors+Show Affiliations

E. N. Rogers Memorial Veterans Hospital, Geriatric Research Education Clinical Center, Bedford, MA 01730, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9309469

Citation

Volicer, L, et al. "Effects of Dronabinol On Anorexia and Disturbed Behavior in Patients With Alzheimer's Disease." International Journal of Geriatric Psychiatry, vol. 12, no. 9, 1997, pp. 913-9.
Volicer L, Stelly M, Morris J, et al. Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. Int J Geriatr Psychiatry. 1997;12(9):913-9.
Volicer, L., Stelly, M., Morris, J., McLaughlin, J., & Volicer, B. J. (1997). Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. International Journal of Geriatric Psychiatry, 12(9), 913-9.
Volicer L, et al. Effects of Dronabinol On Anorexia and Disturbed Behavior in Patients With Alzheimer's Disease. Int J Geriatr Psychiatry. 1997;12(9):913-9. PubMed PMID: 9309469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. AU - Volicer,L, AU - Stelly,M, AU - Morris,J, AU - McLaughlin,J, AU - Volicer,B J, PY - 1997/10/6/pubmed PY - 2000/6/20/medline PY - 1997/10/6/entrez SP - 913 EP - 9 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 12 IS - 9 N2 - A placebo-controlled crossover design, with each treatment period lasting 6 weeks, was used to investigate effects of dronabinol in 15 patients with a diagnosis of probable Alzhemer's disease who were refusing food. Eleven patients completed both study periods; one patient who died of a heart attack 2 weeks before the end of the study was also included in the analysis. The study was terminated in 3 patients: one developed a grand mal seizure and 2 developed serious intercurrent infections. Body weight of study subjects increased more during the dronabinol treatment than during the placebo periods. Dronabinol treatment decreased severity of disturbed behavior and this effect persisted during the placebo period in patients who received dronabinol first. Adverse reactions observed more commonly during the dronabinol treatment than during placebo periods included euphoria, somnolence and tiredness, but did not require discontinuation of therapy. These results indicate that dronabinol is a promising novel therapeutic agent which may be useful not only for treatment of anorexia but also to improve disturbed behavior in patients with Alzheimer's disease. SN - 0885-6230 UR - https://www.unboundmedicine.com/medline/citation/9309469/Effects_of_dronabinol_on_anorexia_and_disturbed_behavior_in_patients_with_Alzheimer's_disease_ L2 - https://medlineplus.gov/alzheimersdisease.html DB - PRIME DP - Unbound Medicine ER -