Tags

Type your tag names separated by a space and hit enter

Trehalases and trehalose hydrolysis in fungi.
FEMS Microbiol Lett 1997; 154(2):165-71FM

Abstract

The simultaneous presence of two different trehalose-hydrolysing activities has been recognised in several fungal species. While these enzymes, known as acid and neutral trehalases, share a strict specificity for trehalose, they are nevertheless rather different in subcellular localisation and in several biochemical and regulatory properties. The function of these apparently redundant activities in the same cell was not completely understood until recently. Biochemical and genetic studies now suggest that these enzymes may have specialised and exclusive roles in fungal cells. It is thought that neutral trehalases mobilise cytosolic trehalose, under the control of developmental programs, chemical and nutrient signals, or stress responses. On the other hand, acid trehalases appear not to mobilise cytosolic trehalose, but to act as 'carbon scavenger' hydrolases enabling cells to utilise exogenous trehalose as a carbon source, under the control of carbon catabolic regulatory circuits. Although much needs to be learned about the molecular identity of trehalases, it seems that in fungi at least one class of acid trehalases evolved independently from the other trehalases.

Authors+Show Affiliations

Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9311112

Citation

Jorge, J A., et al. "Trehalases and Trehalose Hydrolysis in Fungi." FEMS Microbiology Letters, vol. 154, no. 2, 1997, pp. 165-71.
Jorge JA, Polizeli ML, Thevelein JM, et al. Trehalases and trehalose hydrolysis in fungi. FEMS Microbiol Lett. 1997;154(2):165-71.
Jorge, J. A., Polizeli, M. L., Thevelein, J. M., & Terenzi, H. F. (1997). Trehalases and trehalose hydrolysis in fungi. FEMS Microbiology Letters, 154(2), pp. 165-71.
Jorge JA, et al. Trehalases and Trehalose Hydrolysis in Fungi. FEMS Microbiol Lett. 1997 Sep 15;154(2):165-71. PubMed PMID: 9311112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trehalases and trehalose hydrolysis in fungi. AU - Jorge,J A, AU - Polizeli,M L, AU - Thevelein,J M, AU - Terenzi,H F, PY - 1997/10/6/pubmed PY - 1997/10/6/medline PY - 1997/10/6/entrez SP - 165 EP - 71 JF - FEMS microbiology letters JO - FEMS Microbiol. Lett. VL - 154 IS - 2 N2 - The simultaneous presence of two different trehalose-hydrolysing activities has been recognised in several fungal species. While these enzymes, known as acid and neutral trehalases, share a strict specificity for trehalose, they are nevertheless rather different in subcellular localisation and in several biochemical and regulatory properties. The function of these apparently redundant activities in the same cell was not completely understood until recently. Biochemical and genetic studies now suggest that these enzymes may have specialised and exclusive roles in fungal cells. It is thought that neutral trehalases mobilise cytosolic trehalose, under the control of developmental programs, chemical and nutrient signals, or stress responses. On the other hand, acid trehalases appear not to mobilise cytosolic trehalose, but to act as 'carbon scavenger' hydrolases enabling cells to utilise exogenous trehalose as a carbon source, under the control of carbon catabolic regulatory circuits. Although much needs to be learned about the molecular identity of trehalases, it seems that in fungi at least one class of acid trehalases evolved independently from the other trehalases. SN - 0378-1097 UR - https://www.unboundmedicine.com/medline/citation/9311112/Trehalases_and_trehalose_hydrolysis_in_fungi_ L2 - https://academic.oup.com/femsle/article-lookup/doi/10.1111/j.1574-6968.1997.tb12639.x DB - PRIME DP - Unbound Medicine ER -