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The effect of D-fenfluramine on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male and female rats.
Eur J Pharmacol. 1997 Aug 20; 333(1):27-31.EJ

Abstract

Brain regional 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations were determined in freely feeding male and female rats 7 days after giving a single dose of D-fenfluramine (3.8 mg/kg, p.o.) or vehicle. Males showed negligible effects except for a significant decrease of 5-HT in the rest of the cortex, whereas females showed significant decreases of 5-HT and 5-HIAA in the frontal cortex, the rest of the cortex, hippocampus and hypothalamus; 5-HT was also decreased in female midbrain. Females had substantially higher plasma and brain concentrations of fenfluramine and moderately but significantly lower concentrations of norfenfluramine than the males. Plasma fenfluramine + norfenfluramine concentrations of the females were significantly higher than those of the males. Corresponding brain values showed smaller but significant differences. Female brain and plasma areas under the curve for fenfluramine + norfenfluramine (0-24 h after administration of D-fenfluramine) were 20 and 35% higher than male values. However, results suggest that the sex difference in the effect of D-fenfluramine on brain 5-HT metabolism is not due to differences in the metabolism of the drug.

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Publisher Full Text

Authors+Show Affiliations

Datla KP
Department of Neurochemistry, Institute of Neurology, London, UK.
Curzon G
No affiliation info available

MeSH

AnimalsBrain ChemistryFemaleFenfluramineHydroxyindoleacetic AcidMaleNorfenfluramineRatsRats, Sprague-DawleySerotoninSerotonin Uptake InhibitorsSex Characteristics

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9311657

Citation

Datla, K P., and G Curzon. "The Effect of D-fenfluramine On Brain 5-hydroxytryptamine and 5-hydroxyindoleacetic Acid in Male and Female Rats." European Journal of Pharmacology, vol. 333, no. 1, 1997, pp. 27-31.
Datla KP, Curzon G. The effect of D-fenfluramine on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male and female rats. Eur J Pharmacol. 1997;333(1):27-31.
Datla, K. P., & Curzon, G. (1997). The effect of D-fenfluramine on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male and female rats. European Journal of Pharmacology, 333(1), 27-31.
Datla KP, Curzon G. The Effect of D-fenfluramine On Brain 5-hydroxytryptamine and 5-hydroxyindoleacetic Acid in Male and Female Rats. Eur J Pharmacol. 1997 Aug 20;333(1):27-31. PubMed PMID: 9311657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of D-fenfluramine on brain 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in male and female rats. AU - Datla,K P, AU - Curzon,G, PY - 1997/8/20/pubmed PY - 1997/10/6/medline PY - 1997/8/20/entrez SP - 27 EP - 31 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 333 IS - 1 N2 - Brain regional 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) concentrations were determined in freely feeding male and female rats 7 days after giving a single dose of D-fenfluramine (3.8 mg/kg, p.o.) or vehicle. Males showed negligible effects except for a significant decrease of 5-HT in the rest of the cortex, whereas females showed significant decreases of 5-HT and 5-HIAA in the frontal cortex, the rest of the cortex, hippocampus and hypothalamus; 5-HT was also decreased in female midbrain. Females had substantially higher plasma and brain concentrations of fenfluramine and moderately but significantly lower concentrations of norfenfluramine than the males. Plasma fenfluramine + norfenfluramine concentrations of the females were significantly higher than those of the males. Corresponding brain values showed smaller but significant differences. Female brain and plasma areas under the curve for fenfluramine + norfenfluramine (0-24 h after administration of D-fenfluramine) were 20 and 35% higher than male values. However, results suggest that the sex difference in the effect of D-fenfluramine on brain 5-HT metabolism is not due to differences in the metabolism of the drug. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/9311657/The_effect_of_D_fenfluramine_on_brain_5_hydroxytryptamine_and_5_hydroxyindoleacetic_acid_in_male_and_female_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(97)01124-2 DB - PRIME DP - Unbound Medicine ER -