Tags

Type your tag names separated by a space and hit enter

The role of U5 snRNP in pre-mRNA splicing.
EMBO J. 1997 Oct 01; 16(19):5797-800.EJ

Abstract

The current model for the function of the U5 small nuclear ribonucleoprotein particle (snRNP) in the spliceosome proposes that U5 carries binding sites for the 5' and 3' exons, allowing the spliceosome to 'tether' the 5' exon intermediate produced by the first catalytic step and align it with the 3' exon for the second step. Functional analysis of U5 snRNA in cis-spliceosomes has provided support for this model, and data from nematode and trypanosome splicing systems suggest that U5 or a U5-like snRNA performs a similar role in trans-splicing.

Authors+Show Affiliations

MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, UK. newman@mrc-lmb.com.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

9312037

Citation

Newman, A J.. "The Role of U5 snRNP in pre-mRNA Splicing." The EMBO Journal, vol. 16, no. 19, 1997, pp. 5797-800.
Newman AJ. The role of U5 snRNP in pre-mRNA splicing. EMBO J. 1997;16(19):5797-800.
Newman, A. J. (1997). The role of U5 snRNP in pre-mRNA splicing. The EMBO Journal, 16(19), 5797-800.
Newman AJ. The Role of U5 snRNP in pre-mRNA Splicing. EMBO J. 1997 Oct 1;16(19):5797-800. PubMed PMID: 9312037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of U5 snRNP in pre-mRNA splicing. A1 - Newman,A J, PY - 1997/10/6/pubmed PY - 1997/10/6/medline PY - 1997/10/6/entrez SP - 5797 EP - 800 JF - The EMBO journal JO - EMBO J VL - 16 IS - 19 N2 - The current model for the function of the U5 small nuclear ribonucleoprotein particle (snRNP) in the spliceosome proposes that U5 carries binding sites for the 5' and 3' exons, allowing the spliceosome to 'tether' the 5' exon intermediate produced by the first catalytic step and align it with the 3' exon for the second step. Functional analysis of U5 snRNA in cis-spliceosomes has provided support for this model, and data from nematode and trypanosome splicing systems suggest that U5 or a U5-like snRNA performs a similar role in trans-splicing. SN - 0261-4189 UR - https://www.unboundmedicine.com/medline/citation/9312037/The_role_of_U5_snRNP_in_pre_mRNA_splicing_ L2 - https://doi.org/10.1093/emboj/16.19.5797 DB - PRIME DP - Unbound Medicine ER -