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Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation.
J Clin Invest 1997; 100(7):1768-74JCI

Abstract

Maternal protein restriction is a model of fetal programming of adult glucose intolerance. Perfused livers of 48-h- starved adult offspring of rat dams fed 8% protein diets during pregnancy and lactation produced more glucose from 6 mM lactate than did control livers from rats whose dams were fed 20% protein. In control livers, a mean of 24% of the glucose formed from lactate in the periportal region of the lobule was taken up by the most distal perivenous cells; this distal perivenous uptake was greatly diminished in maternal low protein (MLP) livers, accounting for a major fraction of the increased glucose output of MLP livers. In control livers, the distal perivenous cells contained 40% of the total glucokinase of the liver; this perivenous concentration of glucokinase was greatly reduced in MLP livers. Intralobular distribution of phosphenolpyruvate carboxykinase was unaltered, though overall increased activity could have contributed to the elevated glucose output. Hepatic lobular volume in MLP livers was twice that in control livers, indicating that MLP livers had half the normal number of lobules. Fetal programming of adult glucose metabolism may operate partly through structural alterations and changes in glucokinase expression in the immediate perivenous region.

Authors+Show Affiliations

Cellular Mechanisms Research Group, Medical Unit, St. Bartholomew's and the Royal London Hospital School of Medicine and Dentistry, London, United Kingdom. s.p.burns@mds.qmw.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9312176

Citation

Burns, S P., et al. "Gluconeogenesis, Glucose Handling, and Structural Changes in Livers of the Adult Offspring of Rats Partially Deprived of Protein During Pregnancy and Lactation." The Journal of Clinical Investigation, vol. 100, no. 7, 1997, pp. 1768-74.
Burns SP, Desai M, Cohen RD, et al. Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. J Clin Invest. 1997;100(7):1768-74.
Burns, S. P., Desai, M., Cohen, R. D., Hales, C. N., Iles, R. A., Germain, J. P., ... Bailey, R. A. (1997). Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. The Journal of Clinical Investigation, 100(7), pp. 1768-74.
Burns SP, et al. Gluconeogenesis, Glucose Handling, and Structural Changes in Livers of the Adult Offspring of Rats Partially Deprived of Protein During Pregnancy and Lactation. J Clin Invest. 1997 Oct 1;100(7):1768-74. PubMed PMID: 9312176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gluconeogenesis, glucose handling, and structural changes in livers of the adult offspring of rats partially deprived of protein during pregnancy and lactation. AU - Burns,S P, AU - Desai,M, AU - Cohen,R D, AU - Hales,C N, AU - Iles,R A, AU - Germain,J P, AU - Going,T C, AU - Bailey,R A, PY - 1997/10/6/pubmed PY - 1997/10/6/medline PY - 1997/10/6/entrez SP - 1768 EP - 74 JF - The Journal of clinical investigation JO - J. Clin. Invest. VL - 100 IS - 7 N2 - Maternal protein restriction is a model of fetal programming of adult glucose intolerance. Perfused livers of 48-h- starved adult offspring of rat dams fed 8% protein diets during pregnancy and lactation produced more glucose from 6 mM lactate than did control livers from rats whose dams were fed 20% protein. In control livers, a mean of 24% of the glucose formed from lactate in the periportal region of the lobule was taken up by the most distal perivenous cells; this distal perivenous uptake was greatly diminished in maternal low protein (MLP) livers, accounting for a major fraction of the increased glucose output of MLP livers. In control livers, the distal perivenous cells contained 40% of the total glucokinase of the liver; this perivenous concentration of glucokinase was greatly reduced in MLP livers. Intralobular distribution of phosphenolpyruvate carboxykinase was unaltered, though overall increased activity could have contributed to the elevated glucose output. Hepatic lobular volume in MLP livers was twice that in control livers, indicating that MLP livers had half the normal number of lobules. Fetal programming of adult glucose metabolism may operate partly through structural alterations and changes in glucokinase expression in the immediate perivenous region. SN - 0021-9738 UR - https://www.unboundmedicine.com/medline/citation/9312176/Gluconeogenesis_glucose_handling_and_structural_changes_in_livers_of_the_adult_offspring_of_rats_partially_deprived_of_protein_during_pregnancy_and_lactation_ L2 - https://doi.org/10.1172/JCI119703 DB - PRIME DP - Unbound Medicine ER -