Tags

Type your tag names separated by a space and hit enter

National Institutes of Health Consensus Development Conference statement on cervical cancer. April 1-3, 1996.
Gynecol Oncol 1997; 66(3):351-61GO

Abstract

OBJECTIVE

To provide physicians and the general public with a responsible assessment of current screening, prevention, and treatment approaches to cervical cancer.

PARTICIPANTS

The participants were a non-Federal, nonadvocate, 13-member panel representing the fields of obstetrics and gynecology, gynecologic oncology, radiation oncology, and epidemiology. In addition, 28 experts in obstetrics and gynecology, gynecologic oncology, radiation oncology, gynecologic surgery, and psychology presented data to the panel and a conference audience of 500.

EVIDENCE

The literature was searched through Medline and an extensive bibliography of references was provided to the panel and the conference audience. Experts prepared abstracts with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience.

CONSENSUS PROCESS

The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in open forum and the scientific literature. The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after the conference.

CONCLUSIONS

Carcinoma of the cervix is causally related to infection with the human papillomavirus (HPV). Reducing the rate of HPV infection by changes in sexual behaviors in young people and/or through the development of an effective HPV vaccine would reduce the incidence of this disease. Pap smear screening remains the best available method of reducing the incidence and mortality of invasive cervical cancer. Persons with stage IA1 disease have a high cure rate with either simple hysterectomy or, where fertility preservation is an issue, by cone biopsy with clear margins. For patients with stage I and stage IIA disease, radical surgery and radiation are equally effective treatments. These patients should be carefully selected to receive one treatment or the other, but not both, as their combined use substantially increases the cost and morbidity of treatment. Women with more advanced, nonmetastatic disease should be treated with radiation. Recurrent cervical cancer confined to the pelvis should be treated with the modality not previously received. Radiation is recommended to palliate symptoms in patients with metastatic disease.

Pub Type(s)

Consensus Development Conference
Journal Article
Review

Language

eng

PubMed ID

9312522

Citation

"National Institutes of Health Consensus Development Conference Statement On Cervical Cancer. April 1-3, 1996." Gynecologic Oncology, vol. 66, no. 3, 1997, pp. 351-61.
National Institutes of Health Consensus Development Conference statement on cervical cancer. April 1-3, 1996. Gynecol Oncol. 1997;66(3):351-61.
(1997). National Institutes of Health Consensus Development Conference statement on cervical cancer. April 1-3, 1996. Gynecologic Oncology, 66(3), pp. 351-61.
National Institutes of Health Consensus Development Conference Statement On Cervical Cancer. April 1-3, 1996. Gynecol Oncol. 1997;66(3):351-61. PubMed PMID: 9312522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - National Institutes of Health Consensus Development Conference statement on cervical cancer. April 1-3, 1996. PY - 1997/10/6/pubmed PY - 1997/10/6/medline PY - 1997/10/6/entrez SP - 351 EP - 61 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 66 IS - 3 N2 - OBJECTIVE: To provide physicians and the general public with a responsible assessment of current screening, prevention, and treatment approaches to cervical cancer. PARTICIPANTS: The participants were a non-Federal, nonadvocate, 13-member panel representing the fields of obstetrics and gynecology, gynecologic oncology, radiation oncology, and epidemiology. In addition, 28 experts in obstetrics and gynecology, gynecologic oncology, radiation oncology, gynecologic surgery, and psychology presented data to the panel and a conference audience of 500. EVIDENCE: The literature was searched through Medline and an extensive bibliography of references was provided to the panel and the conference audience. Experts prepared abstracts with relevant citations from the literature. Scientific evidence was given precedence over clinical anecdotal experience. CONSENSUS PROCESS: The panel, answering predefined questions, developed their conclusions based on the scientific evidence presented in open forum and the scientific literature. The panel composed a draft statement that was read in its entirety and circulated to the experts and the audience for comment. Thereafter, the panel resolved conflicting recommendations and released a revised statement at the end of the conference. The panel finalized the revisions within a few weeks after the conference. CONCLUSIONS: Carcinoma of the cervix is causally related to infection with the human papillomavirus (HPV). Reducing the rate of HPV infection by changes in sexual behaviors in young people and/or through the development of an effective HPV vaccine would reduce the incidence of this disease. Pap smear screening remains the best available method of reducing the incidence and mortality of invasive cervical cancer. Persons with stage IA1 disease have a high cure rate with either simple hysterectomy or, where fertility preservation is an issue, by cone biopsy with clear margins. For patients with stage I and stage IIA disease, radical surgery and radiation are equally effective treatments. These patients should be carefully selected to receive one treatment or the other, but not both, as their combined use substantially increases the cost and morbidity of treatment. Women with more advanced, nonmetastatic disease should be treated with radiation. Recurrent cervical cancer confined to the pelvis should be treated with the modality not previously received. Radiation is recommended to palliate symptoms in patients with metastatic disease. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/9312522/National_Institutes_of_Health_Consensus_Development_Conference_statement_on_cervical_cancer__April_1_3_1996_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090825897948496 DB - PRIME DP - Unbound Medicine ER -