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Decreasing common carotid artery intimal thickness during hypolipidemic therapy.
Angiology. 1997 Sep; 48(9):761-7.A

Abstract

It has been demonstrated in recent years that ultrasound can be used to measure common carotid artery intimal thickness; an increase in intimal thickness is regarded as an early stage of atherosclerosis. This study was designed to establish whether or not intimal thickness can be modulated by therapy. Twenty-nine patients with familial hyperlipoproteinemias had follow-up ultrasound of the common carotid artery after twenty-nine months of comprehensive therapy. In 21 patients with familial hypercholesterolemia, intimal thickness decreased from 0.83 to 0.68 mm (P < 0.01), in 9 with familial combined hyperlipoproteinemia, the decrease was from 0.77 to 0.74 mm (a decrease was seen in only 50% of patients). With the group taken as a whole, the larger decrease was observed in patients treated with statins while the reduction was less marked in those administered fibrates. The authors found a decrease in common carotid artery intimal thickness following hypolipidemic therapy in patients with hyperlipoproteinemias. Their impression is that this was a manifestation of atherosclerosis regression.

Authors+Show Affiliations

3rd Department of Internal Medicine, General Teaching Hospital, Prague, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9313625

Citation

Spácil, J, et al. "Decreasing Common Carotid Artery Intimal Thickness During Hypolipidemic Therapy." Angiology, vol. 48, no. 9, 1997, pp. 761-7.
Spácil J, Ceska R, Sobra J, et al. Decreasing common carotid artery intimal thickness during hypolipidemic therapy. Angiology. 1997;48(9):761-7.
Spácil, J., Ceska, R., Sobra, J., & Petrásek, J. (1997). Decreasing common carotid artery intimal thickness during hypolipidemic therapy. Angiology, 48(9), 761-7.
Spácil J, et al. Decreasing Common Carotid Artery Intimal Thickness During Hypolipidemic Therapy. Angiology. 1997;48(9):761-7. PubMed PMID: 9313625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreasing common carotid artery intimal thickness during hypolipidemic therapy. AU - Spácil,J, AU - Ceska,R, AU - Sobra,J, AU - Petrásek,J, PY - 1997/10/6/pubmed PY - 1997/10/6/medline PY - 1997/10/6/entrez SP - 761 EP - 7 JF - Angiology JO - Angiology VL - 48 IS - 9 N2 - It has been demonstrated in recent years that ultrasound can be used to measure common carotid artery intimal thickness; an increase in intimal thickness is regarded as an early stage of atherosclerosis. This study was designed to establish whether or not intimal thickness can be modulated by therapy. Twenty-nine patients with familial hyperlipoproteinemias had follow-up ultrasound of the common carotid artery after twenty-nine months of comprehensive therapy. In 21 patients with familial hypercholesterolemia, intimal thickness decreased from 0.83 to 0.68 mm (P < 0.01), in 9 with familial combined hyperlipoproteinemia, the decrease was from 0.77 to 0.74 mm (a decrease was seen in only 50% of patients). With the group taken as a whole, the larger decrease was observed in patients treated with statins while the reduction was less marked in those administered fibrates. The authors found a decrease in common carotid artery intimal thickness following hypolipidemic therapy in patients with hyperlipoproteinemias. Their impression is that this was a manifestation of atherosclerosis regression. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/9313625/Decreasing_common_carotid_artery_intimal_thickness_during_hypolipidemic_therapy_ L2 - https://journals.sagepub.com/doi/10.1177/000331979704800902?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -