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Investigation into the increase in hay fever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts.
BMJ. 1997 Sep 20; 315(7110):717-21.BMJ

Abstract

OBJECTIVE

To investigate whether changes in certain perinatal and social factors explain the increased prevalence of hay fever and eczema among British adolescents between 1974 and 1986.

DESIGN

Two prospective birth cohort studies.

SETTING

England, Wales, and Scotland.

SUBJECTS

11,195 children born 3-9 March 1958 and 9387 born 5-11 April 1970.

MAIN OUTCOME MEASURES

Parental reports of eczematous rashes and of hay fever or allergic rhinitis in the previous 12 months at age 16.

RESULTS

The prevalence of the conditions over the 12 month period increased between 1974 and 1986 from 3.1% to 6.4% (prevalence ratio 2.04 (95% confidence interval 1.79 to 2.32)) for eczema and from 12.0% to 23.3% (prevalence ratio 1.93 (1.82 to 2.06)) for hay fever. Both conditions were more commonly reported among children of higher birth order and those who were breast fed for longer than 1 month. Eczema was more commonly reported among girls and hay fever among boys. The prevalence of hay fever decreased sharply between social classes I and V, increased with maternal age up to the early 30s, and was lower in children whose mothers smoked during pregnancy. Neither condition varied significantly with birth weight. When adjusted for these factors, the relative odds of hay fever (1986 v 1974) increased from 2.23 (2.05 to 2.43) to 2.40 (2.19 to 2.63). Similarly, the relative odds of eczema rose from 2.02 (1.73 to 2.36) to 2.14 (1.81 to 2.52).

CONCLUSIONS

Taken together, changes between cohorts in sex, birth weight, birth order, maternal age, breast feeding, maternal smoking during pregnancy, and father's social class at birth did not seem to explain any of the observed rise in the prevalence of hay fever and eczema. However, correlates of these factors which have changed over time may still underlie recent increases in allergic disease.

Authors+Show Affiliations

Department of Public Health Sciences, St George's Hospital Medical School, London.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9314757

Citation

Butland, B K., et al. "Investigation Into the Increase in Hay Fever and Eczema at Age 16 Observed Between the 1958 and 1970 British Birth Cohorts." BMJ (Clinical Research Ed.), vol. 315, no. 7110, 1997, pp. 717-21.
Butland BK, Strachan DP, Lewis S, et al. Investigation into the increase in hay fever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts. BMJ. 1997;315(7110):717-21.
Butland, B. K., Strachan, D. P., Lewis, S., Bynner, J., Butler, N., & Britton, J. (1997). Investigation into the increase in hay fever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts. BMJ (Clinical Research Ed.), 315(7110), 717-21.
Butland BK, et al. Investigation Into the Increase in Hay Fever and Eczema at Age 16 Observed Between the 1958 and 1970 British Birth Cohorts. BMJ. 1997 Sep 20;315(7110):717-21. PubMed PMID: 9314757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation into the increase in hay fever and eczema at age 16 observed between the 1958 and 1970 British birth cohorts. AU - Butland,B K, AU - Strachan,D P, AU - Lewis,S, AU - Bynner,J, AU - Butler,N, AU - Britton,J, PY - 1997/10/7/pubmed PY - 1997/10/7/medline PY - 1997/10/7/entrez SP - 717 EP - 21 JF - BMJ (Clinical research ed.) JO - BMJ VL - 315 IS - 7110 N2 - OBJECTIVE: To investigate whether changes in certain perinatal and social factors explain the increased prevalence of hay fever and eczema among British adolescents between 1974 and 1986. DESIGN: Two prospective birth cohort studies. SETTING: England, Wales, and Scotland. SUBJECTS: 11,195 children born 3-9 March 1958 and 9387 born 5-11 April 1970. MAIN OUTCOME MEASURES: Parental reports of eczematous rashes and of hay fever or allergic rhinitis in the previous 12 months at age 16. RESULTS: The prevalence of the conditions over the 12 month period increased between 1974 and 1986 from 3.1% to 6.4% (prevalence ratio 2.04 (95% confidence interval 1.79 to 2.32)) for eczema and from 12.0% to 23.3% (prevalence ratio 1.93 (1.82 to 2.06)) for hay fever. Both conditions were more commonly reported among children of higher birth order and those who were breast fed for longer than 1 month. Eczema was more commonly reported among girls and hay fever among boys. The prevalence of hay fever decreased sharply between social classes I and V, increased with maternal age up to the early 30s, and was lower in children whose mothers smoked during pregnancy. Neither condition varied significantly with birth weight. When adjusted for these factors, the relative odds of hay fever (1986 v 1974) increased from 2.23 (2.05 to 2.43) to 2.40 (2.19 to 2.63). Similarly, the relative odds of eczema rose from 2.02 (1.73 to 2.36) to 2.14 (1.81 to 2.52). CONCLUSIONS: Taken together, changes between cohorts in sex, birth weight, birth order, maternal age, breast feeding, maternal smoking during pregnancy, and father's social class at birth did not seem to explain any of the observed rise in the prevalence of hay fever and eczema. However, correlates of these factors which have changed over time may still underlie recent increases in allergic disease. SN - 0959-8138 UR - https://www.unboundmedicine.com/medline/citation/9314757/Investigation_into_the_increase_in_hay_fever_and_eczema_at_age_16_observed_between_the_1958_and_1970_British_birth_cohorts_ L2 - https://www.bmj.com/lookup/pmidlookup?view=long&pmid=9314757 DB - PRIME DP - Unbound Medicine ER -