Tags

Type your tag names separated by a space and hit enter

Hepatitis C virus recurrence after liver transplantation: relationship to anti-HCV core IgM, genotype, and level of viremia.
Am J Gastroenterol 1997; 92(9):1458-62AJ

Abstract

OBJECTIVES

Factors that determine the severity of hepatitis C virus (HCV)-recurrent disease in patients undergoing orthotopic liver transplantation (OLT) for HCV cirrhosis have not been clearly identified. To address this issue, we evaluated the histological and virological outcome in 25 patients who underwent OLT for HCV cirrhosis.

METHODS

HCV-RNA was detected by qualitative and quantitative polymerase chain reaction. The HCV genotype also was determined by polymerase chain reaction. Anti-HCV core IgM was tested by ELISA. Disease severity was expressed as a histological score.

RESULTS

Sixteen patients had evidence of HCV-recurrent disease. HCV-RNA levels before transplantation (p = 0.029) and after transplantation (15 days, p = 0.004; 90 days, p = 0.040; 360 days, p = 0.010) were significantly higher among patients who subsequently developed recurrent hepatitis than among those who did not. The presence of anti-HCV core IgM before (p = 0.044) and after OLT (15 days, p = 0.017; 90 days, p = 0.037; and 360 days, p = 0.040) was significantly related to recurrence of hepatitis. The genotype was not related to the level of viremia, to the prevalence of recurrent hepatitis, to the presence of anti-HCV core IgM, or to disease severity.

CONCLUSIONS

The recurrence of HCV hepatitis in patients undergoing OLT for HCV cirrhosis is related to higher levels of viremia and the presence of anti-HCV core IgM, but not to the HCV genotype. However, disease severity is not related to viremia levels, HCV genotype, or positivity of anti-HCV core IgM.

Authors+Show Affiliations

Department of Molecular Biology, Faculty of Medicine, University Hospital Marqués de Valdecilla, Santander, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9317062

Citation

Crespo, J, et al. "Hepatitis C Virus Recurrence After Liver Transplantation: Relationship to anti-HCV Core IgM, Genotype, and Level of Viremia." The American Journal of Gastroenterology, vol. 92, no. 9, 1997, pp. 1458-62.
Crespo J, Carte B, Lozano JL, et al. Hepatitis C virus recurrence after liver transplantation: relationship to anti-HCV core IgM, genotype, and level of viremia. Am J Gastroenterol. 1997;92(9):1458-62.
Crespo, J., Carte, B., Lozano, J. L., Casafont, F., Rivero, M., de la Cruz, F., & Pons-Romero, F. (1997). Hepatitis C virus recurrence after liver transplantation: relationship to anti-HCV core IgM, genotype, and level of viremia. The American Journal of Gastroenterology, 92(9), pp. 1458-62.
Crespo J, et al. Hepatitis C Virus Recurrence After Liver Transplantation: Relationship to anti-HCV Core IgM, Genotype, and Level of Viremia. Am J Gastroenterol. 1997;92(9):1458-62. PubMed PMID: 9317062.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatitis C virus recurrence after liver transplantation: relationship to anti-HCV core IgM, genotype, and level of viremia. AU - Crespo,J, AU - Carte,B, AU - Lozano,J L, AU - Casafont,F, AU - Rivero,M, AU - de la Cruz,F, AU - Pons-Romero,F, PY - 1997/10/8/pubmed PY - 1997/10/8/medline PY - 1997/10/8/entrez SP - 1458 EP - 62 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 92 IS - 9 N2 - OBJECTIVES: Factors that determine the severity of hepatitis C virus (HCV)-recurrent disease in patients undergoing orthotopic liver transplantation (OLT) for HCV cirrhosis have not been clearly identified. To address this issue, we evaluated the histological and virological outcome in 25 patients who underwent OLT for HCV cirrhosis. METHODS: HCV-RNA was detected by qualitative and quantitative polymerase chain reaction. The HCV genotype also was determined by polymerase chain reaction. Anti-HCV core IgM was tested by ELISA. Disease severity was expressed as a histological score. RESULTS: Sixteen patients had evidence of HCV-recurrent disease. HCV-RNA levels before transplantation (p = 0.029) and after transplantation (15 days, p = 0.004; 90 days, p = 0.040; 360 days, p = 0.010) were significantly higher among patients who subsequently developed recurrent hepatitis than among those who did not. The presence of anti-HCV core IgM before (p = 0.044) and after OLT (15 days, p = 0.017; 90 days, p = 0.037; and 360 days, p = 0.040) was significantly related to recurrence of hepatitis. The genotype was not related to the level of viremia, to the prevalence of recurrent hepatitis, to the presence of anti-HCV core IgM, or to disease severity. CONCLUSIONS: The recurrence of HCV hepatitis in patients undergoing OLT for HCV cirrhosis is related to higher levels of viremia and the presence of anti-HCV core IgM, but not to the HCV genotype. However, disease severity is not related to viremia levels, HCV genotype, or positivity of anti-HCV core IgM. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9317062/Hepatitis_C_virus_recurrence_after_liver_transplantation:_relationship_to_anti_HCV_core_IgM_genotype_and_level_of_viremia_ L2 - http://www.diseaseinfosearch.org/result/3333 DB - PRIME DP - Unbound Medicine ER -