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The inter-relationships of tardive dyskinesia, parkinsonism, akathisia and tardive dystonia: the Curaçao Extrapyramidal Syndromes Study II.
Schizophr Res. 1997 Aug 29; 26(2-3):235-42.SR

Abstract

A study of the four extrapyramidal syndromes (EPS), tardive dyskinesia, parkinsonism, akathisia and tardive dystonia, was performed in the Netherlands Antilles, a well-defined catchment area with only one psychiatric hospital. The population under study (N = 194; mean age 53.1) was mainly Afro-Caribbean, and most patients were chronic. The severity of each EPS was measured with valid and reliable rating scales. The purpose was to study both the strength of the inter-relationships of EPS and the prevalence of combinations of EPS. The inter-relationships between the EPS were analyzed by means of logistic regression. The adjusted odds ratios between the various EPS revealed strong connections between the hyperkinetic syndromes (tardive dyskinesia, tardive dystonia and akathisia). Parkinsonism was found to be inversely related to tardive dyskinesia and to tardive dystonia. Almost 30% of the patients suffered from two or more EPS. The highest prevalence rates of combinations were: tardive dyskinesia combined with parkinsonism 12.9%, tardive dyskinesia combined with tardive dystonia 9.8%, and tardive dyskinesia combined with akathisia 5.2%. Our findings show a strong positive correlation between hyperkinetic forms of EPS. Furthermore, chronic psychiatric inpatients regularly suffer from combinations of EPS. Different treatment strategies are suggested for various combinations of EPS.

Authors+Show Affiliations

Dr. D.R. Capriles Clinic, Curaçao, Netherlands Antilles.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9323356

Citation

van Harten, P N., et al. "The Inter-relationships of Tardive Dyskinesia, Parkinsonism, Akathisia and Tardive Dystonia: the Curaçao Extrapyramidal Syndromes Study II." Schizophrenia Research, vol. 26, no. 2-3, 1997, pp. 235-42.
van Harten PN, Hoek HW, Matroos GE, et al. The inter-relationships of tardive dyskinesia, parkinsonism, akathisia and tardive dystonia: the Curaçao Extrapyramidal Syndromes Study II. Schizophr Res. 1997;26(2-3):235-42.
van Harten, P. N., Hoek, H. W., Matroos, G. E., Koeter, M., & Kahn, R. S. (1997). The inter-relationships of tardive dyskinesia, parkinsonism, akathisia and tardive dystonia: the Curaçao Extrapyramidal Syndromes Study II. Schizophrenia Research, 26(2-3), 235-42.
van Harten PN, et al. The Inter-relationships of Tardive Dyskinesia, Parkinsonism, Akathisia and Tardive Dystonia: the Curaçao Extrapyramidal Syndromes Study II. Schizophr Res. 1997 Aug 29;26(2-3):235-42. PubMed PMID: 9323356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The inter-relationships of tardive dyskinesia, parkinsonism, akathisia and tardive dystonia: the Curaçao Extrapyramidal Syndromes Study II. AU - van Harten,P N, AU - Hoek,H W, AU - Matroos,G E, AU - Koeter,M, AU - Kahn,R S, PY - 1997/8/29/pubmed PY - 1997/11/5/medline PY - 1997/8/29/entrez SP - 235 EP - 42 JF - Schizophrenia research JO - Schizophr Res VL - 26 IS - 2-3 N2 - A study of the four extrapyramidal syndromes (EPS), tardive dyskinesia, parkinsonism, akathisia and tardive dystonia, was performed in the Netherlands Antilles, a well-defined catchment area with only one psychiatric hospital. The population under study (N = 194; mean age 53.1) was mainly Afro-Caribbean, and most patients were chronic. The severity of each EPS was measured with valid and reliable rating scales. The purpose was to study both the strength of the inter-relationships of EPS and the prevalence of combinations of EPS. The inter-relationships between the EPS were analyzed by means of logistic regression. The adjusted odds ratios between the various EPS revealed strong connections between the hyperkinetic syndromes (tardive dyskinesia, tardive dystonia and akathisia). Parkinsonism was found to be inversely related to tardive dyskinesia and to tardive dystonia. Almost 30% of the patients suffered from two or more EPS. The highest prevalence rates of combinations were: tardive dyskinesia combined with parkinsonism 12.9%, tardive dyskinesia combined with tardive dystonia 9.8%, and tardive dyskinesia combined with akathisia 5.2%. Our findings show a strong positive correlation between hyperkinetic forms of EPS. Furthermore, chronic psychiatric inpatients regularly suffer from combinations of EPS. Different treatment strategies are suggested for various combinations of EPS. SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/9323356/The_inter_relationships_of_tardive_dyskinesia_parkinsonism_akathisia_and_tardive_dystonia:_the_Curaçao_Extrapyramidal_Syndromes_Study_II_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(97)00058-3 DB - PRIME DP - Unbound Medicine ER -