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Gastrinoma before Zollinger and Ellison.
Am J Surg. 1997 Sep; 174(3):232-6.AJ

Abstract

BACKGROUND

The 1955 landmark publication by Zollinger and Ellison characterized the gastrinoma syndrome and presented a hypothesis for the pancreatic endocrine origin of the gastric hypersecretion and dramatic ulcer diathesis.

METHODS

A detailed review of the literature was conducted to ascertain the clinical and pathologic spectrum of gastrinoma reported prior to the definition of the Zollinger-Ellison syndrome.

RESULTS

In addition to the 2 patients presented by Zollinger and Ellison, 6 published reports of gastrinoma patients were referenced in their manuscript. An additional 6 patients were described by the 5 discussants of the presented paper. Thorough review of the literature has yielded 4, and possibly 6, additional cases of gastrinoma published between 1908 and 1952.

CONCLUSION

Despite experience with a sizeable number of gastrinoma patients, it was left to Zollinger and Ellison to define the association between the islet cell tumor, its peptide hormone, and the clinical manifestations of severe gastric hypersecretion. Their seminal contribution served as the defining moment for the field of gastrointestinal endocrinology.

Authors+Show Affiliations

Department of Surgery, Harbor-UCLA Medical Center, Torrance, California 90509, USA.

Pub Type(s)

Historical Article
Journal Article
Review

Language

eng

PubMed ID

9324128

Citation

Stabile, B E.. "Gastrinoma Before Zollinger and Ellison." American Journal of Surgery, vol. 174, no. 3, 1997, pp. 232-6.
Stabile BE. Gastrinoma before Zollinger and Ellison. Am J Surg. 1997;174(3):232-6.
Stabile, B. E. (1997). Gastrinoma before Zollinger and Ellison. American Journal of Surgery, 174(3), 232-6.
Stabile BE. Gastrinoma Before Zollinger and Ellison. Am J Surg. 1997;174(3):232-6. PubMed PMID: 9324128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrinoma before Zollinger and Ellison. A1 - Stabile,B E, PY - 1997/10/27/pubmed PY - 1997/10/27/medline PY - 1997/10/27/entrez SP - 232 EP - 6 JF - American journal of surgery JO - Am. J. Surg. VL - 174 IS - 3 N2 - BACKGROUND: The 1955 landmark publication by Zollinger and Ellison characterized the gastrinoma syndrome and presented a hypothesis for the pancreatic endocrine origin of the gastric hypersecretion and dramatic ulcer diathesis. METHODS: A detailed review of the literature was conducted to ascertain the clinical and pathologic spectrum of gastrinoma reported prior to the definition of the Zollinger-Ellison syndrome. RESULTS: In addition to the 2 patients presented by Zollinger and Ellison, 6 published reports of gastrinoma patients were referenced in their manuscript. An additional 6 patients were described by the 5 discussants of the presented paper. Thorough review of the literature has yielded 4, and possibly 6, additional cases of gastrinoma published between 1908 and 1952. CONCLUSION: Despite experience with a sizeable number of gastrinoma patients, it was left to Zollinger and Ellison to define the association between the islet cell tumor, its peptide hormone, and the clinical manifestations of severe gastric hypersecretion. Their seminal contribution served as the defining moment for the field of gastrointestinal endocrinology. SN - 0002-9610 UR - https://www.unboundmedicine.com/medline/citation/9324128/Gastrinoma_before_Zollinger_and_Ellison_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002961097001311 DB - PRIME DP - Unbound Medicine ER -
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