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Tracking the MEN1 gene.
Am J Surg. 1997 Sep; 174(3):266-70.AJ

Abstract

Multiple endocrine neoplasia type 1 (MEN1) is a hereditary autosomal dominant disease characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. Sporadic forms of these tumors are more common than their inherited counterparts and share common genetic abnormalities. We have been studying the molecular genetics of sporadic pancreatic endocrine tumors to identify the tumor suppressor gene responsible for MEN1 by positional cloning. This review introduces the reader to the fundamentals of these molecular genetic techniques and outlines the general strategy used to isolate this gene.

Authors+Show Affiliations

Department of Surgery, West Los Angeles Veterans Affairs Medical Center, and the University of California, Los Angeles, School of Medicine, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9324134

Citation

Ebrahimi, S A., and M P. Sawicki. "Tracking the MEN1 Gene." American Journal of Surgery, vol. 174, no. 3, 1997, pp. 266-70.
Ebrahimi SA, Sawicki MP. Tracking the MEN1 gene. Am J Surg. 1997;174(3):266-70.
Ebrahimi, S. A., & Sawicki, M. P. (1997). Tracking the MEN1 gene. American Journal of Surgery, 174(3), 266-70.
Ebrahimi SA, Sawicki MP. Tracking the MEN1 Gene. Am J Surg. 1997;174(3):266-70. PubMed PMID: 9324134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tracking the MEN1 gene. AU - Ebrahimi,S A, AU - Sawicki,M P, PY - 1997/10/27/pubmed PY - 1997/10/27/medline PY - 1997/10/27/entrez SP - 266 EP - 70 JF - American journal of surgery JO - Am J Surg VL - 174 IS - 3 N2 - Multiple endocrine neoplasia type 1 (MEN1) is a hereditary autosomal dominant disease characterized by parathyroid hyperplasia, pancreatic endocrine tumors, and pituitary adenomas. Sporadic forms of these tumors are more common than their inherited counterparts and share common genetic abnormalities. We have been studying the molecular genetics of sporadic pancreatic endocrine tumors to identify the tumor suppressor gene responsible for MEN1 by positional cloning. This review introduces the reader to the fundamentals of these molecular genetic techniques and outlines the general strategy used to isolate this gene. SN - 0002-9610 UR - https://www.unboundmedicine.com/medline/citation/9324134/Tracking_the_MEN1_gene_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002961097001438 DB - PRIME DP - Unbound Medicine ER -