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Feline atopic dermatitis. A model for Langerhans cell participation in disease pathogenesis.
Am J Pathol. 1997 Oct; 151(4):927-32.AJ

Abstract

Atopic dermatitis is a disorder characterized by cutaneous exanthemata as a consequence of exaggerated eczematous reactions to topical and systemic allergens. Langerhans cells, expressing CD1a and HLA-DR, and dermal dendritic cells, expressing HLA-DR, are known to be potent antigen-presenting cells and are thought to play an important role in the pathogenesis of atopic dermatitis. The immunophenotype of lesional skin in atopic dermatitis in humans involves increased numbers of CD1a+/MHC class II+ dendritic cells in addition to activated T cells, mast cells, and macrophages. To establish feline skin as a model for the study of human atopic dermatitis, and to elucidate the role of dendritic cells in feline atopic dermatitis, we investigated the presence of CD1a+ cells and MHC class II+ cells in the epidermis and dermis of lesional feline skin and in skin of healthy control animals. Immunohistochemistry revealed that MHC class II+ epidermal dendritic cells were CD1a+ in normal feline skin and significantly increased numbers of CD1a+ cells and MHC class II+ cells were present in the epidermis and dermis of lesional skin. These data provide the first correlative documentation of CD1a expression by feline dendritic cells containing Birbeck granules, and indicate the utility of feline skin in the study of human cutaneous atopy.

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Authors+Show Affiliations

Roosje PJ
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA.
Whitaker-Menezes D
No affiliation info available
Goldschmidt MH
No affiliation info available
Moore PF
No affiliation info available
Willemse T
No affiliation info available
Murphy GF
No affiliation info available

MeSH

AnimalsAntigens, CD1Cat DiseasesCatsCell CountDendritic CellsDermatitis, AtopicDisease Models, AnimalFemaleGenes, MHC Class IIImmunohistochemistryLangerhans CellsMaleSkin

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9327725

Citation

Roosje, P J., et al. "Feline Atopic Dermatitis. a Model for Langerhans Cell Participation in Disease Pathogenesis." The American Journal of Pathology, vol. 151, no. 4, 1997, pp. 927-32.
Roosje PJ, Whitaker-Menezes D, Goldschmidt MH, et al. Feline atopic dermatitis. A model for Langerhans cell participation in disease pathogenesis. Am J Pathol. 1997;151(4):927-32.
Roosje, P. J., Whitaker-Menezes, D., Goldschmidt, M. H., Moore, P. F., Willemse, T., & Murphy, G. F. (1997). Feline atopic dermatitis. A model for Langerhans cell participation in disease pathogenesis. The American Journal of Pathology, 151(4), 927-32.
Roosje PJ, et al. Feline Atopic Dermatitis. a Model for Langerhans Cell Participation in Disease Pathogenesis. Am J Pathol. 1997;151(4):927-32. PubMed PMID: 9327725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Feline atopic dermatitis. A model for Langerhans cell participation in disease pathogenesis. AU - Roosje,P J, AU - Whitaker-Menezes,D, AU - Goldschmidt,M H, AU - Moore,P F, AU - Willemse,T, AU - Murphy,G F, PY - 1997/11/5/pubmed PY - 1997/11/5/medline PY - 1997/11/5/entrez SP - 927 EP - 32 JF - The American journal of pathology JO - Am J Pathol VL - 151 IS - 4 N2 - Atopic dermatitis is a disorder characterized by cutaneous exanthemata as a consequence of exaggerated eczematous reactions to topical and systemic allergens. Langerhans cells, expressing CD1a and HLA-DR, and dermal dendritic cells, expressing HLA-DR, are known to be potent antigen-presenting cells and are thought to play an important role in the pathogenesis of atopic dermatitis. The immunophenotype of lesional skin in atopic dermatitis in humans involves increased numbers of CD1a+/MHC class II+ dendritic cells in addition to activated T cells, mast cells, and macrophages. To establish feline skin as a model for the study of human atopic dermatitis, and to elucidate the role of dendritic cells in feline atopic dermatitis, we investigated the presence of CD1a+ cells and MHC class II+ cells in the epidermis and dermis of lesional feline skin and in skin of healthy control animals. Immunohistochemistry revealed that MHC class II+ epidermal dendritic cells were CD1a+ in normal feline skin and significantly increased numbers of CD1a+ cells and MHC class II+ cells were present in the epidermis and dermis of lesional skin. These data provide the first correlative documentation of CD1a expression by feline dendritic cells containing Birbeck granules, and indicate the utility of feline skin in the study of human cutaneous atopy. SN - 0002-9440 UR - https://www.unboundmedicine.com/medline/citation/9327725/Feline_atopic_dermatitis__A_model_for_Langerhans_cell_participation_in_disease_pathogenesis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9327725/ DB - PRIME DP - Unbound Medicine ER -