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Density of gamma/delta+ T cells in the jejunal epithelium of patients with coeliac disease and dermatitis herpetiformis is increased with age.
Clin Exp Immunol. 1997 Sep; 109(3):464-7.CE

Abstract

Increased density of gamma/delta T cell receptor (TCR)+ intraepithelial lymphocytes is the only characteristic in the jejunum of patients with coeliac disease and dermatitis herpetiformis which is not normalized on a gluten-free diet. We explored the age-dependent changes in intraepithelial gamma/delta and alpha/beta TCR+ cells from 137 biopsies from patients with coeliac disease and dermatitis herpetiformis and from controls. Biopsy specimens from 100 patients with coeliac disease and dermatitis herpetiformis and from 37 controls were studied with an immunohistochemical method using MoAbs to T cell receptors and peroxidase staining. An increase in the density of intraepithelial gamma/delta T cells above the mean +2 s.d. of the density in controls was present in 97 of 100 specimens from patients with coeliac disease and dermatitis herpetiformis. The density of gamma/delta+ cells of patients with coeliac disease and dermatitis herpetiformis on a normal gluten-containing diet showed a positive correlation with age (r = 0.45, P < 0.0001). In controls, the density of gamma/delta+ cells remained low throughout the age-range studies, from age 0.6-57 years. In controls, alpha/beta+ cells increased with age (r = 0.57, P < 0.001). The increase in density of intraepithelial lymphocytes with age is in agreement with their thymus-independent character and local proliferation.

Authors+Show Affiliations

The Children's Hospital, University of Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9328123

Citation

Savilahti, E, et al. "Density of Gamma/delta+ T Cells in the Jejunal Epithelium of Patients With Coeliac Disease and Dermatitis Herpetiformis Is Increased With Age." Clinical and Experimental Immunology, vol. 109, no. 3, 1997, pp. 464-7.
Savilahti E, Ormälä T, Arato A, et al. Density of gamma/delta+ T cells in the jejunal epithelium of patients with coeliac disease and dermatitis herpetiformis is increased with age. Clin Exp Immunol. 1997;109(3):464-7.
Savilahti, E., Ormälä, T., Arato, A., Hacsek, G., Holm, K., Klemola, T., Nemeth, A., Mäki, M., & Reunala, T. (1997). Density of gamma/delta+ T cells in the jejunal epithelium of patients with coeliac disease and dermatitis herpetiformis is increased with age. Clinical and Experimental Immunology, 109(3), 464-7.
Savilahti E, et al. Density of Gamma/delta+ T Cells in the Jejunal Epithelium of Patients With Coeliac Disease and Dermatitis Herpetiformis Is Increased With Age. Clin Exp Immunol. 1997;109(3):464-7. PubMed PMID: 9328123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Density of gamma/delta+ T cells in the jejunal epithelium of patients with coeliac disease and dermatitis herpetiformis is increased with age. AU - Savilahti,E, AU - Ormälä,T, AU - Arato,A, AU - Hacsek,G, AU - Holm,K, AU - Klemola,T, AU - Nemeth,A, AU - Mäki,M, AU - Reunala,T, PY - 1997/10/27/pubmed PY - 1997/10/27/medline PY - 1997/10/27/entrez SP - 464 EP - 7 JF - Clinical and experimental immunology JO - Clin Exp Immunol VL - 109 IS - 3 N2 - Increased density of gamma/delta T cell receptor (TCR)+ intraepithelial lymphocytes is the only characteristic in the jejunum of patients with coeliac disease and dermatitis herpetiformis which is not normalized on a gluten-free diet. We explored the age-dependent changes in intraepithelial gamma/delta and alpha/beta TCR+ cells from 137 biopsies from patients with coeliac disease and dermatitis herpetiformis and from controls. Biopsy specimens from 100 patients with coeliac disease and dermatitis herpetiformis and from 37 controls were studied with an immunohistochemical method using MoAbs to T cell receptors and peroxidase staining. An increase in the density of intraepithelial gamma/delta T cells above the mean +2 s.d. of the density in controls was present in 97 of 100 specimens from patients with coeliac disease and dermatitis herpetiformis. The density of gamma/delta+ cells of patients with coeliac disease and dermatitis herpetiformis on a normal gluten-containing diet showed a positive correlation with age (r = 0.45, P < 0.0001). In controls, the density of gamma/delta+ cells remained low throughout the age-range studies, from age 0.6-57 years. In controls, alpha/beta+ cells increased with age (r = 0.57, P < 0.001). The increase in density of intraepithelial lymphocytes with age is in agreement with their thymus-independent character and local proliferation. SN - 0009-9104 UR - https://www.unboundmedicine.com/medline/citation/9328123/Density_of_gamma/delta+_T_cells_in_the_jejunal_epithelium_of_patients_with_coeliac_disease_and_dermatitis_herpetiformis_is_increased_with_age_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0009-9104&amp;date=1997&amp;volume=109&amp;issue=3&amp;spage=464 DB - PRIME DP - Unbound Medicine ER -