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Movement characteristics in Parkinson's disease: determination of dopaminergic responsiveness and threshold.
Clin Neuropharmacol. 1997 Oct; 20(5):402-8.CN

Abstract

We evaluated the responsiveness of tap rate (TR), movement time (MT), and reaction time (RT) to intravenous (i.v.) (n = 10) and subcutaneous (s.c.) (n = 16) administration of apomorphine in patients with Parkinson's disease (PD). In the second part of this study, we evaluated the feasibility of the commonly used 15% TR threshold, above which a patient is considered to be a responder. Compared to MT, TR emerged as the most responsive measure of bradykinesia during both i.v. and s.c. administration of apomorphine. RT showed no response to dopaminergic stimulation. To evaluate the influence of threshold on the number of responsive sessions, we determined the baseline variability of TR by means of the coefficient of variation (CV) in 39 patients with PD. Our results show approximately similar numbers of responsive sessions using the 15% and 2CV threshold. Our findings suggest that a simple repetitive motor task--TR--is more responsive than is the MT task. Finally, the 15% threshold may be considered an adequate threshold for TR in assessment of dopaminergic responsiveness of bradykinesia.

Authors+Show Affiliations

Department of Neurology, Leiden University Hospital, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

9331516

Citation

van Hilten, J J., et al. "Movement Characteristics in Parkinson's Disease: Determination of Dopaminergic Responsiveness and Threshold." Clinical Neuropharmacology, vol. 20, no. 5, 1997, pp. 402-8.
van Hilten JJ, Wagemans EA, Ghafoerkhan SF, et al. Movement characteristics in Parkinson's disease: determination of dopaminergic responsiveness and threshold. Clin Neuropharmacol. 1997;20(5):402-8.
van Hilten, J. J., Wagemans, E. A., Ghafoerkhan, S. F., & van Laar, T. (1997). Movement characteristics in Parkinson's disease: determination of dopaminergic responsiveness and threshold. Clinical Neuropharmacology, 20(5), 402-8.
van Hilten JJ, et al. Movement Characteristics in Parkinson's Disease: Determination of Dopaminergic Responsiveness and Threshold. Clin Neuropharmacol. 1997;20(5):402-8. PubMed PMID: 9331516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Movement characteristics in Parkinson's disease: determination of dopaminergic responsiveness and threshold. AU - van Hilten,J J, AU - Wagemans,E A, AU - Ghafoerkhan,S F, AU - van Laar,T, PY - 1997/10/23/pubmed PY - 1997/10/23/medline PY - 1997/10/23/entrez SP - 402 EP - 8 JF - Clinical neuropharmacology JO - Clin Neuropharmacol VL - 20 IS - 5 N2 - We evaluated the responsiveness of tap rate (TR), movement time (MT), and reaction time (RT) to intravenous (i.v.) (n = 10) and subcutaneous (s.c.) (n = 16) administration of apomorphine in patients with Parkinson's disease (PD). In the second part of this study, we evaluated the feasibility of the commonly used 15% TR threshold, above which a patient is considered to be a responder. Compared to MT, TR emerged as the most responsive measure of bradykinesia during both i.v. and s.c. administration of apomorphine. RT showed no response to dopaminergic stimulation. To evaluate the influence of threshold on the number of responsive sessions, we determined the baseline variability of TR by means of the coefficient of variation (CV) in 39 patients with PD. Our results show approximately similar numbers of responsive sessions using the 15% and 2CV threshold. Our findings suggest that a simple repetitive motor task--TR--is more responsive than is the MT task. Finally, the 15% threshold may be considered an adequate threshold for TR in assessment of dopaminergic responsiveness of bradykinesia. SN - 0362-5664 UR - https://www.unboundmedicine.com/medline/citation/9331516/Movement_characteristics_in_Parkinson's_disease:_determination_of_dopaminergic_responsiveness_and_threshold_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9331516.ui DB - PRIME DP - Unbound Medicine ER -