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Solid nonpalpable breast lesions. Success and failure of guided fine-needle aspiration cytology in a consecutive series of 2444 cases.
Acta Radiol. 1997 Sep; 38(5):815-20.AR

Abstract

PURPOSE

To evaluate the contribution of guided fine-needle aspiration cytology in reducing unnecessary biopsies of benign solid nonpalpable breast lesions with low suspicion of malignancy at mammography.

MATERIAL AND METHODS

An evaluation was made of a consecutive series of 2444 solid nonpalpable breast lesions detected by mammography and undergoing guided (sonography or stereotaxy) fine-needle aspiration cytology. Surgical biopsy was made in the presence of strong suspicion of malignancy at mammography and/or of abnormal cytology.

RESULTS

The sensitivity was 96.7% and the specificity 77.7% (average follow-up 2.77 years). False-negative/inadequate cytology associated with low suspicion of malignancy at mammography resulted in a diagnostic delay in 27 cancer cases (invasive 20, intraductal 7). On the other hand, cytology led to surgical biopsy in 53 cancer cases which might not otherwise have been biopsied because of low radiological suspicion of cancer. Surgical biopsy of all cases, to avoid diagnostic delays, would have increased the benign biopsy rate by a factor of 4.5, with a rise in the benign: malignant biopsy ratio from 0.44:1 to 1.93:1.

CONCLUSION

Stereotaxy- or ultrasound-guided fine-needle aspiration cytology of nonpalpable mammographic abnormalities can achieve a sharp reduction in unnecessary benign biopsies in cases of low suspicion of malignancy at mammography.

Authors+Show Affiliations

Research Center for Preventive Oncology, Florence, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9332236

Citation

Ciatto, S, et al. "Solid Nonpalpable Breast Lesions. Success and Failure of Guided Fine-needle Aspiration Cytology in a Consecutive Series of 2444 Cases." Acta Radiologica (Stockholm, Sweden : 1987), vol. 38, no. 5, 1997, pp. 815-20.
Ciatto S, Rosselli Del Turco M, Ambrogetti D, et al. Solid nonpalpable breast lesions. Success and failure of guided fine-needle aspiration cytology in a consecutive series of 2444 cases. Acta Radiol. 1997;38(5):815-20.
Ciatto, S., Rosselli Del Turco, M., Ambrogetti, D., Bravetti, P., Catarzi, S., Morrone, D., & Cariaggi, M. P. (1997). Solid nonpalpable breast lesions. Success and failure of guided fine-needle aspiration cytology in a consecutive series of 2444 cases. Acta Radiologica (Stockholm, Sweden : 1987), 38(5), 815-20.
Ciatto S, et al. Solid Nonpalpable Breast Lesions. Success and Failure of Guided Fine-needle Aspiration Cytology in a Consecutive Series of 2444 Cases. Acta Radiol. 1997;38(5):815-20. PubMed PMID: 9332236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Solid nonpalpable breast lesions. Success and failure of guided fine-needle aspiration cytology in a consecutive series of 2444 cases. AU - Ciatto,S, AU - Rosselli Del Turco,M, AU - Ambrogetti,D, AU - Bravetti,P, AU - Catarzi,S, AU - Morrone,D, AU - Cariaggi,M P, PY - 1997/10/23/pubmed PY - 1997/10/23/medline PY - 1997/10/23/entrez SP - 815 EP - 20 JF - Acta radiologica (Stockholm, Sweden : 1987) JO - Acta Radiol VL - 38 IS - 5 N2 - PURPOSE: To evaluate the contribution of guided fine-needle aspiration cytology in reducing unnecessary biopsies of benign solid nonpalpable breast lesions with low suspicion of malignancy at mammography. MATERIAL AND METHODS: An evaluation was made of a consecutive series of 2444 solid nonpalpable breast lesions detected by mammography and undergoing guided (sonography or stereotaxy) fine-needle aspiration cytology. Surgical biopsy was made in the presence of strong suspicion of malignancy at mammography and/or of abnormal cytology. RESULTS: The sensitivity was 96.7% and the specificity 77.7% (average follow-up 2.77 years). False-negative/inadequate cytology associated with low suspicion of malignancy at mammography resulted in a diagnostic delay in 27 cancer cases (invasive 20, intraductal 7). On the other hand, cytology led to surgical biopsy in 53 cancer cases which might not otherwise have been biopsied because of low radiological suspicion of cancer. Surgical biopsy of all cases, to avoid diagnostic delays, would have increased the benign biopsy rate by a factor of 4.5, with a rise in the benign: malignant biopsy ratio from 0.44:1 to 1.93:1. CONCLUSION: Stereotaxy- or ultrasound-guided fine-needle aspiration cytology of nonpalpable mammographic abnormalities can achieve a sharp reduction in unnecessary benign biopsies in cases of low suspicion of malignancy at mammography. SN - 0284-1851 UR - https://www.unboundmedicine.com/medline/citation/9332236/Solid_nonpalpable_breast_lesions__Success_and_failure_of_guided_fine_needle_aspiration_cytology_in_a_consecutive_series_of_2444_cases_ L2 - https://journals.sagepub.com/doi/10.1080/02841859709172416?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -