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[The effect of dialysis solutions containing amino acids on the nutritional status of patients treated with continuous ambulatory peritoneal dialysis].
Cas Lek Cesk. 1997 Jun 26; 136(13):409-12.CL

Abstract

BACKGROUND

In the patient population which is subjected to haemodialysis or peritoneal dialysis is a high prevalence of protein-energy malnutrition which independently on the causal factor causes a deterioration of their prognosis. To influence protein nutrition in patients on peritoneal dialysis Nutrineal was developed, i.e., a dialysis solution using as an osmotic agent a 1.1% amino acid mixture instead of glucose used as a rule. The objective of the present study was to evaluate the effect of its administration on some nutritional indicators in patients treated by continuous ambulatory peritoneal dialysis (CAPD) and to assess its tolerance.

METHODS AND RESULTS

The authors investigated eight patients aged 45.5 years (29-78 years, median, minimal and maximal value), treated for 19.9 (5-42) months by CAPD. For a period of four weeks Nutrineal was administered once a day instead of glucose based solution to patients without diseases complicating nutrition, with a serum albumin concentration (ALB) below 35 (20-34) g/l. Before treatment and after its termination an anthropometric examination was made, the rate of protein catabolism was examined (PCR), plasma concentrations of total proteins were assessed, as well as ALB, transferrin (TRF) and 14 free amino acids substituted by the dialysis solution. For statistical comparison the paired Wilcoxon test was used. As compared with the baseline value of 0.83 g/kg/24 h after treatment a significant increase of PCR was recorded--to 0.96 g/kg/24 h (p < 0.05) as well as a significant increase of the urea concentration from 18.4 (10.9-34.8) mmol/l to 26.7 (19.6-33) mmol/l (p < 0.05). The value of phosphorus declined significantly from 2.25 (1.6-2.6) to 1.9 (0.9-2.5) mmol/l (p < 0.05). No significant difference was recorded in the anthropometric findings and in concentrations of total proteins, ALB, TRF and amino acids.

CONCLUSIONS

Four weeks administration of a solution with amino acids raised significantly the PCR which may be indirect evidence of an anabolic effect and it reduced plasma phosphates which participate in uraemic toxicity. The solution was well tolerated by the patients. Final evaluation of the values of the solution containing amino acids calls for long-term and controlled studies.

Authors+Show Affiliations

I. interní klinika LF UK a FN, Plzen, Bioanalytická laborator Cepha, Plzeń.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

cze

PubMed ID

9333515

Citation

Opatrná, S, et al. "[The Effect of Dialysis Solutions Containing Amino Acids On the Nutritional Status of Patients Treated With Continuous Ambulatory Peritoneal Dialysis]." Casopis Lekaru Ceskych, vol. 136, no. 13, 1997, pp. 409-12.
Opatrná S, Liska J, Vít L, et al. [The effect of dialysis solutions containing amino acids on the nutritional status of patients treated with continuous ambulatory peritoneal dialysis]. Cas Lek Cesk. 1997;136(13):409-12.
Opatrná, S., Liska, J., Vít, L., Hostasová, A., & Opatrný, K. (1997). [The effect of dialysis solutions containing amino acids on the nutritional status of patients treated with continuous ambulatory peritoneal dialysis]. Casopis Lekaru Ceskych, 136(13), 409-12.
Opatrná S, et al. [The Effect of Dialysis Solutions Containing Amino Acids On the Nutritional Status of Patients Treated With Continuous Ambulatory Peritoneal Dialysis]. Cas Lek Cesk. 1997 Jun 26;136(13):409-12. PubMed PMID: 9333515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The effect of dialysis solutions containing amino acids on the nutritional status of patients treated with continuous ambulatory peritoneal dialysis]. AU - Opatrná,S, AU - Liska,J, AU - Vít,L, AU - Hostasová,A, AU - Opatrný,K,Jr PY - 1997/6/26/pubmed PY - 2001/3/28/medline PY - 1997/6/26/entrez SP - 409 EP - 12 JF - Casopis lekaru ceskych JO - Cas. Lek. Cesk. VL - 136 IS - 13 N2 - BACKGROUND: In the patient population which is subjected to haemodialysis or peritoneal dialysis is a high prevalence of protein-energy malnutrition which independently on the causal factor causes a deterioration of their prognosis. To influence protein nutrition in patients on peritoneal dialysis Nutrineal was developed, i.e., a dialysis solution using as an osmotic agent a 1.1% amino acid mixture instead of glucose used as a rule. The objective of the present study was to evaluate the effect of its administration on some nutritional indicators in patients treated by continuous ambulatory peritoneal dialysis (CAPD) and to assess its tolerance. METHODS AND RESULTS: The authors investigated eight patients aged 45.5 years (29-78 years, median, minimal and maximal value), treated for 19.9 (5-42) months by CAPD. For a period of four weeks Nutrineal was administered once a day instead of glucose based solution to patients without diseases complicating nutrition, with a serum albumin concentration (ALB) below 35 (20-34) g/l. Before treatment and after its termination an anthropometric examination was made, the rate of protein catabolism was examined (PCR), plasma concentrations of total proteins were assessed, as well as ALB, transferrin (TRF) and 14 free amino acids substituted by the dialysis solution. For statistical comparison the paired Wilcoxon test was used. As compared with the baseline value of 0.83 g/kg/24 h after treatment a significant increase of PCR was recorded--to 0.96 g/kg/24 h (p < 0.05) as well as a significant increase of the urea concentration from 18.4 (10.9-34.8) mmol/l to 26.7 (19.6-33) mmol/l (p < 0.05). The value of phosphorus declined significantly from 2.25 (1.6-2.6) to 1.9 (0.9-2.5) mmol/l (p < 0.05). No significant difference was recorded in the anthropometric findings and in concentrations of total proteins, ALB, TRF and amino acids. CONCLUSIONS: Four weeks administration of a solution with amino acids raised significantly the PCR which may be indirect evidence of an anabolic effect and it reduced plasma phosphates which participate in uraemic toxicity. The solution was well tolerated by the patients. Final evaluation of the values of the solution containing amino acids calls for long-term and controlled studies. SN - 0008-7335 UR - https://www.unboundmedicine.com/medline/citation/9333515/[The_effect_of_dialysis_solutions_containing_amino_acids_on_the_nutritional_status_of_patients_treated_with_continuous_ambulatory_peritoneal_dialysis]_ DB - PRIME DP - Unbound Medicine ER -