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Discriminative stimulus effects of magnesium chloride: substitution studies with monoamine uptake inhibitors and N-methyl-D-aspartate antagonists.
J Pharmacol Exp Ther. 1997 Oct; 283(1):200-6.JP

Abstract

Previous studies suggest that magnesium chloride may have discriminative stimulus effects that partially overlap with those of noncompetitive N-methyl-D-aspartate antagonists as well as certain monoamine uptake inhibitors. In our study, rats were trained to discriminate 100 mg/kg magnesium chloride from saline and its discriminative stimulus effects were characterized with respect to N-methyl-D-aspartate receptor and monoamine transporter functions in substitution tests. The discriminative stimulus effects of magnesium chloride were acquired within a moderate number of training sessions and showed dose-related substitution after either subcutaneous (3-300 mg/kg) or intracerebroventricular (0.3-300 microg) administration. The intracerebroventricular administration of magnesium chloride was over 4000 times more potent than its s.c. administration. The monoamine uptake inhibitors cocaine, GBR 12909, talsupram and citalopram fully substituted (> or =90% magnesium-appropriate responses) for magnesium chloride in the majority of subjects tested and the group averages reached a maximum of 72 to 82% responses on the magnesium-appropriate lever. Based on relative potency analysis, the rank order of potency of these four drugs for producing magnesium-appropriate responses was talsupram = cocaine > citalopram = GBR 12909. The N-methyl-D-aspartate receptor antagonists dizocilpine, phencyclidine and NPC 17742 engendered maximum group averages of 49 to 65% responses on the magnesium-appropriate lever. The results suggest that the centrally mediated discriminative stimulus effects of magnesium chloride may be more directly related to interactions with monoamine neurotransmitter functions than to N-methyl-D-aspartate receptor blockade.

Authors+Show Affiliations

Department of Psychology, Boston University, Massachusetts 02215, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9336325

Citation

Kantak, K M., et al. "Discriminative Stimulus Effects of Magnesium Chloride: Substitution Studies With Monoamine Uptake Inhibitors and N-methyl-D-aspartate Antagonists." The Journal of Pharmacology and Experimental Therapeutics, vol. 283, no. 1, 1997, pp. 200-6.
Kantak KM, Edwards MA, Wilcox KM, et al. Discriminative stimulus effects of magnesium chloride: substitution studies with monoamine uptake inhibitors and N-methyl-D-aspartate antagonists. J Pharmacol Exp Ther. 1997;283(1):200-6.
Kantak, K. M., Edwards, M. A., Wilcox, K. M., & Kitchel, E. (1997). Discriminative stimulus effects of magnesium chloride: substitution studies with monoamine uptake inhibitors and N-methyl-D-aspartate antagonists. The Journal of Pharmacology and Experimental Therapeutics, 283(1), 200-6.
Kantak KM, et al. Discriminative Stimulus Effects of Magnesium Chloride: Substitution Studies With Monoamine Uptake Inhibitors and N-methyl-D-aspartate Antagonists. J Pharmacol Exp Ther. 1997;283(1):200-6. PubMed PMID: 9336325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Discriminative stimulus effects of magnesium chloride: substitution studies with monoamine uptake inhibitors and N-methyl-D-aspartate antagonists. AU - Kantak,K M, AU - Edwards,M A, AU - Wilcox,K M, AU - Kitchel,E, PY - 1997/10/23/pubmed PY - 1997/10/23/medline PY - 1997/10/23/entrez SP - 200 EP - 6 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 283 IS - 1 N2 - Previous studies suggest that magnesium chloride may have discriminative stimulus effects that partially overlap with those of noncompetitive N-methyl-D-aspartate antagonists as well as certain monoamine uptake inhibitors. In our study, rats were trained to discriminate 100 mg/kg magnesium chloride from saline and its discriminative stimulus effects were characterized with respect to N-methyl-D-aspartate receptor and monoamine transporter functions in substitution tests. The discriminative stimulus effects of magnesium chloride were acquired within a moderate number of training sessions and showed dose-related substitution after either subcutaneous (3-300 mg/kg) or intracerebroventricular (0.3-300 microg) administration. The intracerebroventricular administration of magnesium chloride was over 4000 times more potent than its s.c. administration. The monoamine uptake inhibitors cocaine, GBR 12909, talsupram and citalopram fully substituted (> or =90% magnesium-appropriate responses) for magnesium chloride in the majority of subjects tested and the group averages reached a maximum of 72 to 82% responses on the magnesium-appropriate lever. Based on relative potency analysis, the rank order of potency of these four drugs for producing magnesium-appropriate responses was talsupram = cocaine > citalopram = GBR 12909. The N-methyl-D-aspartate receptor antagonists dizocilpine, phencyclidine and NPC 17742 engendered maximum group averages of 49 to 65% responses on the magnesium-appropriate lever. The results suggest that the centrally mediated discriminative stimulus effects of magnesium chloride may be more directly related to interactions with monoamine neurotransmitter functions than to N-methyl-D-aspartate receptor blockade. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/9336325/Discriminative_stimulus_effects_of_magnesium_chloride:_substitution_studies_with_monoamine_uptake_inhibitors_and_N_methyl_D_aspartate_antagonists_ L2 - http://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=9336325 DB - PRIME DP - Unbound Medicine ER -