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Nitric oxide inhibition after hypoxia-ischemia elevates pulmonary arterial pressure and increases oxygen need.
Biol Neonate. 1997; 72(4):227-34.BN

Abstract

Inhibition of nitric oxide (NO) production may reduce post-hypoxic-ischemic (HI) neonatal brain damage, but may also induce pulmonary hypertension by inhibiting endogenous NO production in the pulmonary vascular bed. The aim of this study was to evaluate the effect of nitric oxide inhibition on pulmonary artery pressure and oxygen need after hypoxic ischemia. Severe HI was produced in 18 newborn lambs. After completion of HI the lambs were divided into three groups of 6 animals receiving either placebo (Cont), low dose N omega-nitro-L-arginine (10 mg/kg i.v., NLA-10) or high dose (40 mg/kg i.v., NLA-40) to block NO production. Pulmonary artery pressure (Pap), aortic pressure, blood gases, inspiratory oxygen concentration and ventilator settings were recorded before and 15, 60, 120 and 180 min after HI. Mean Pap rose initially significantly as compared to baseline in all groups at 15 min post-HI, decreased to normal in Cont but not in treated animals; 180 min post-HI mean Pap was significantly higher in both treated groups as compared to control (NLA-10: 32 mm Hg, NLA-40: 34 mm Hg, Cont: 25 mm Hg, p < 0.05 for NLA-10 and NLA-40 vs. Cont). Moreover, in both NLA-treated groups the oxygenation index was significantly elevated 120 and 180 min post-HI as compared to those of the Cont group. NO synthase inhibition after HI causes a prolonged increase in pulmonary artery pressure leading to a higher oxygen need.

Authors+Show Affiliations

Division of Neonatology, Leiden University Hospital, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9339294

Citation

de Beaufort, A J., et al. "Nitric Oxide Inhibition After Hypoxia-ischemia Elevates Pulmonary Arterial Pressure and Increases Oxygen Need." Biology of the Neonate, vol. 72, no. 4, 1997, pp. 227-34.
de Beaufort AJ, Lopes Cardozo RH, Dorrepaal CA, et al. Nitric oxide inhibition after hypoxia-ischemia elevates pulmonary arterial pressure and increases oxygen need. Biol Neonate. 1997;72(4):227-34.
de Beaufort, A. J., Lopes Cardozo, R. H., Dorrepaal, C. A., Steendijk, P., Van Der Velde, E. T., & Van Bel, F. (1997). Nitric oxide inhibition after hypoxia-ischemia elevates pulmonary arterial pressure and increases oxygen need. Biology of the Neonate, 72(4), 227-34.
de Beaufort AJ, et al. Nitric Oxide Inhibition After Hypoxia-ischemia Elevates Pulmonary Arterial Pressure and Increases Oxygen Need. Biol Neonate. 1997;72(4):227-34. PubMed PMID: 9339294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitric oxide inhibition after hypoxia-ischemia elevates pulmonary arterial pressure and increases oxygen need. AU - de Beaufort,A J, AU - Lopes Cardozo,R H, AU - Dorrepaal,C A, AU - Steendijk,P, AU - Van Der Velde,E T, AU - Van Bel,F, PY - 1997/1/1/pubmed PY - 1997/10/27/medline PY - 1997/1/1/entrez SP - 227 EP - 34 JF - Biology of the neonate JO - Biol Neonate VL - 72 IS - 4 N2 - Inhibition of nitric oxide (NO) production may reduce post-hypoxic-ischemic (HI) neonatal brain damage, but may also induce pulmonary hypertension by inhibiting endogenous NO production in the pulmonary vascular bed. The aim of this study was to evaluate the effect of nitric oxide inhibition on pulmonary artery pressure and oxygen need after hypoxic ischemia. Severe HI was produced in 18 newborn lambs. After completion of HI the lambs were divided into three groups of 6 animals receiving either placebo (Cont), low dose N omega-nitro-L-arginine (10 mg/kg i.v., NLA-10) or high dose (40 mg/kg i.v., NLA-40) to block NO production. Pulmonary artery pressure (Pap), aortic pressure, blood gases, inspiratory oxygen concentration and ventilator settings were recorded before and 15, 60, 120 and 180 min after HI. Mean Pap rose initially significantly as compared to baseline in all groups at 15 min post-HI, decreased to normal in Cont but not in treated animals; 180 min post-HI mean Pap was significantly higher in both treated groups as compared to control (NLA-10: 32 mm Hg, NLA-40: 34 mm Hg, Cont: 25 mm Hg, p < 0.05 for NLA-10 and NLA-40 vs. Cont). Moreover, in both NLA-treated groups the oxygenation index was significantly elevated 120 and 180 min post-HI as compared to those of the Cont group. NO synthase inhibition after HI causes a prolonged increase in pulmonary artery pressure leading to a higher oxygen need. SN - 0006-3126 UR - https://www.unboundmedicine.com/medline/citation/9339294/Nitric_oxide_inhibition_after_hypoxia_ischemia_elevates_pulmonary_arterial_pressure_and_increases_oxygen_need_ L2 - https://antibodies.cancer.gov/detail/CPTC-ASAP1-1 DB - PRIME DP - Unbound Medicine ER -