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Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture.
Planta Med. 1997 Oct; 63(5):429-32.PM

Abstract

A sulphated galactan (SG) with low molecular weight (app. 2800) was isolated from extracts of Cryptopleura ramosa, a red seaweed from the South American coasts. The compound was a selective inhibitor of HSV-1 and HSV-2 replication in Vero cells with 50% inhibitory concentrations (IC50) in the range 1.6-4.2 micrograms/ml and a 50% cytotoxic concentration (CC50) of 476 micrograms/ml. SG was also effective against HSV-1 in cells of neural origin such as murine astrocytes. The mode of action of SG could be ascribed to an inhibitory action on virus adsorption. Furthermore, SG did not inhibit the blood coagulation process at concentrations highly exceeding the IC50.

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Authors+Show Affiliations

Carlucci MJ
Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Scolaro LA
No affiliation info available
Errea MI
No affiliation info available
Matulewicz MC
No affiliation info available
Damonte EB
No affiliation info available

MeSH

AnimalsAntiviral AgentsAstrocytesCell SurvivalCells, CulturedChlorocebus aethiopsGalactansHerpesvirus 1, HumanHerpesvirus 2, HumanHumansMicePlants, MedicinalRhodophytaSeawaterVero CellsVirus Replication

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9342947

Citation

Carlucci, M J., et al. "Antiviral Activity of Natural Sulphated Galactans On Herpes Virus Multiplication in Cell Culture." Planta Medica, vol. 63, no. 5, 1997, pp. 429-32.
Carlucci MJ, Scolaro LA, Errea MI, et al. Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture. Planta Med. 1997;63(5):429-32.
Carlucci, M. J., Scolaro, L. A., Errea, M. I., Matulewicz, M. C., & Damonte, E. B. (1997). Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture. Planta Medica, 63(5), 429-32.
Carlucci MJ, et al. Antiviral Activity of Natural Sulphated Galactans On Herpes Virus Multiplication in Cell Culture. Planta Med. 1997;63(5):429-32. PubMed PMID: 9342947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiviral activity of natural sulphated galactans on herpes virus multiplication in cell culture. AU - Carlucci,M J, AU - Scolaro,L A, AU - Errea,M I, AU - Matulewicz,M C, AU - Damonte,E B, PY - 1997/10/29/pubmed PY - 1997/10/29/medline PY - 1997/10/29/entrez SP - 429 EP - 32 JF - Planta medica JO - Planta Med VL - 63 IS - 5 N2 - A sulphated galactan (SG) with low molecular weight (app. 2800) was isolated from extracts of Cryptopleura ramosa, a red seaweed from the South American coasts. The compound was a selective inhibitor of HSV-1 and HSV-2 replication in Vero cells with 50% inhibitory concentrations (IC50) in the range 1.6-4.2 micrograms/ml and a 50% cytotoxic concentration (CC50) of 476 micrograms/ml. SG was also effective against HSV-1 in cells of neural origin such as murine astrocytes. The mode of action of SG could be ascribed to an inhibitory action on virus adsorption. Furthermore, SG did not inhibit the blood coagulation process at concentrations highly exceeding the IC50. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/9342947/Antiviral_activity_of_natural_sulphated_galactans_on_herpes_virus_multiplication_in_cell_culture_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-957727 DB - PRIME DP - Unbound Medicine ER -