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Acute-phase reactants and plasma trace element concentrations in non-small cell lung cancer patients and controls.
Nutr Cancer 1997; 28(3):308-12NC

Abstract

This study examined the effect of an acute-phase response on plasma trace element concentrations of non-small cell lung cancer (NSCLC) patients. In normal subjects (n = 13) and NSCLC patients (n = 22), fasting concentrations of albumin, C-reactive protein, the trace elements iron, zinc, copper, and selenium, and their associated proteins transferrin, albumin, ceruloplasmin, and glutathione peroxidase were measured. The NSCLC patients were subdivided into two equal groups depending on whether they had a C-reactive protein concentration < 35 mg/l (Group 1) or > 35 mg/l (Group 2). Circulating zinc, iron, and transferrin concentrations were significantly lower in NSCLC Group 1 than in the control group (p < 0.05). Circulating concentrations of iron, zinc, and the binding proteins transferrin and albumin were significantly lower in NSCLC Group 2 than in the control group and NSCLC Group 1 (zinc not significantly different) (p < 0.01). In contrast circulating concentrations of copper and its binding protein ceruloplasmin were significantly increased in NSCLC Group 2 compared with NSCLC Group 1 and the control group (p < 0.01). Additionally, plasma selenium and glutathione peroxidase concentrations were significantly lower (p < 0.05) in NSCLC Group 2 than in NSCLC Group 1 and the control group. In the NSCLC patients there were significant negative correlations between concentrations of C-reactive protein and iron, transferrin, zinc, albumin, and selenium (p < 0.05). Furthermore, there were also significant positive correlations between C-reactive protein and copper (r = 0.788, p < 0.001) and ceruloplasmin (r = 0.831, p < 0.001) concentrations. The presence of an acute-phase response has implications for the interpretation of circulating trace element concentrations, the status of patients with NSCLC, and supplementation with trace elements in patients with NSCLC.

Authors+Show Affiliations

Department of Pathological Biochemistry, Royal Infirmary University NHS Trust, Glasgow, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9343841

Citation

Sattar, N, et al. "Acute-phase Reactants and Plasma Trace Element Concentrations in Non-small Cell Lung Cancer Patients and Controls." Nutrition and Cancer, vol. 28, no. 3, 1997, pp. 308-12.
Sattar N, Scott HR, McMillan DC, et al. Acute-phase reactants and plasma trace element concentrations in non-small cell lung cancer patients and controls. Nutr Cancer. 1997;28(3):308-12.
Sattar, N., Scott, H. R., McMillan, D. C., Talwar, D., O'Reilly, D. S., & Fell, G. S. (1997). Acute-phase reactants and plasma trace element concentrations in non-small cell lung cancer patients and controls. Nutrition and Cancer, 28(3), pp. 308-12.
Sattar N, et al. Acute-phase Reactants and Plasma Trace Element Concentrations in Non-small Cell Lung Cancer Patients and Controls. Nutr Cancer. 1997;28(3):308-12. PubMed PMID: 9343841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute-phase reactants and plasma trace element concentrations in non-small cell lung cancer patients and controls. AU - Sattar,N, AU - Scott,H R, AU - McMillan,D C, AU - Talwar,D, AU - O'Reilly,D S, AU - Fell,G S, PY - 1997/1/1/pubmed PY - 1997/10/31/medline PY - 1997/1/1/entrez SP - 308 EP - 12 JF - Nutrition and cancer JO - Nutr Cancer VL - 28 IS - 3 N2 - This study examined the effect of an acute-phase response on plasma trace element concentrations of non-small cell lung cancer (NSCLC) patients. In normal subjects (n = 13) and NSCLC patients (n = 22), fasting concentrations of albumin, C-reactive protein, the trace elements iron, zinc, copper, and selenium, and their associated proteins transferrin, albumin, ceruloplasmin, and glutathione peroxidase were measured. The NSCLC patients were subdivided into two equal groups depending on whether they had a C-reactive protein concentration < 35 mg/l (Group 1) or > 35 mg/l (Group 2). Circulating zinc, iron, and transferrin concentrations were significantly lower in NSCLC Group 1 than in the control group (p < 0.05). Circulating concentrations of iron, zinc, and the binding proteins transferrin and albumin were significantly lower in NSCLC Group 2 than in the control group and NSCLC Group 1 (zinc not significantly different) (p < 0.01). In contrast circulating concentrations of copper and its binding protein ceruloplasmin were significantly increased in NSCLC Group 2 compared with NSCLC Group 1 and the control group (p < 0.01). Additionally, plasma selenium and glutathione peroxidase concentrations were significantly lower (p < 0.05) in NSCLC Group 2 than in NSCLC Group 1 and the control group. In the NSCLC patients there were significant negative correlations between concentrations of C-reactive protein and iron, transferrin, zinc, albumin, and selenium (p < 0.05). Furthermore, there were also significant positive correlations between C-reactive protein and copper (r = 0.788, p < 0.001) and ceruloplasmin (r = 0.831, p < 0.001) concentrations. The presence of an acute-phase response has implications for the interpretation of circulating trace element concentrations, the status of patients with NSCLC, and supplementation with trace elements in patients with NSCLC. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/9343841/Acute_phase_reactants_and_plasma_trace_element_concentrations_in_non_small_cell_lung_cancer_patients_and_controls_ L2 - http://www.tandfonline.com/doi/full/10.1080/01635589709514592 DB - PRIME DP - Unbound Medicine ER -