Tags

Type your tag names separated by a space and hit enter

Protein intake and urinary albumin excretion rates in the EURODIAB IDDM Complications Study.

Abstract

For people with insulin-dependent diabetes mellitus (IDDM) renal disease represents a life-threatening and costly complication. The EURODIAB IDDM Complications Study, a cross-sectional, clinic-based study, was designed to determine the prevalence of renal complications and putative risk factors in stratified samples of European individuals with IDDM. The present study examined the relationship between dietary protein intake and urinary albumin excretion rate (AER). Food intake was assessed centrally by a standardized 3-day dietary record. Urinary AER was determined in a central laboratory from a timed 24-h urine collection. Complete data were available from 2696 persons with IDDM from 30 centres in 16 European countries. In individuals who reported protein consumption less than 20% of total food energy intake, mean AER was below 20 microg/min. In those in whom protein intake constituted more than 20%, mean AER increased, a trend particularly pronounced in individuals with hypertension and/or poor metabolic control. Trends reached statistical significance for intakes of total protein (% of energy, p = 0.01) and animal protein (% of energy, p = 0.02), while no association was seen for vegetable protein (p = 0.83). These findings support the current recommendation for people with diabetes not to exceed a protein intake of 20% of total energy. Monitoring and adjustment of dietary protein appears particularly desirable for individuals with AER exceeding 20 microg/min (approximately 30 mg/24h), especially when arterial pressure is raised and/or diabetic control is poor.

Authors+Show Affiliations

,

Diabetes Research Institute at the Heinrich-Heine-University, Clinical Department, Düsseldorf, Germany.

, , , , , ,

Source

Diabetologia 40:10 1997 Oct pg 1219-26

MeSH

Adolescent
Adult
Albuminuria
Cross-Sectional Studies
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Dietary Proteins
Europe
Female
Humans
Male
Middle Aged

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9349605

Citation

Toeller, M, et al. "Protein Intake and Urinary Albumin Excretion Rates in the EURODIAB IDDM Complications Study." Diabetologia, vol. 40, no. 10, 1997, pp. 1219-26.
Toeller M, Buyken A, Heitkamp G, et al. Protein intake and urinary albumin excretion rates in the EURODIAB IDDM Complications Study. Diabetologia. 1997;40(10):1219-26.
Toeller, M., Buyken, A., Heitkamp, G., Brämswig, S., Mann, J., Milne, R., ... Keen, H. (1997). Protein intake and urinary albumin excretion rates in the EURODIAB IDDM Complications Study. Diabetologia, 40(10), pp. 1219-26.
Toeller M, et al. Protein Intake and Urinary Albumin Excretion Rates in the EURODIAB IDDM Complications Study. Diabetologia. 1997;40(10):1219-26. PubMed PMID: 9349605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein intake and urinary albumin excretion rates in the EURODIAB IDDM Complications Study. AU - Toeller,M, AU - Buyken,A, AU - Heitkamp,G, AU - Brämswig,S, AU - Mann,J, AU - Milne,R, AU - Gries,F A, AU - Keen,H, PY - 1998/2/12/pubmed PY - 1998/2/12/medline PY - 1998/2/12/entrez SP - 1219 EP - 26 JF - Diabetologia JO - Diabetologia VL - 40 IS - 10 N2 - For people with insulin-dependent diabetes mellitus (IDDM) renal disease represents a life-threatening and costly complication. The EURODIAB IDDM Complications Study, a cross-sectional, clinic-based study, was designed to determine the prevalence of renal complications and putative risk factors in stratified samples of European individuals with IDDM. The present study examined the relationship between dietary protein intake and urinary albumin excretion rate (AER). Food intake was assessed centrally by a standardized 3-day dietary record. Urinary AER was determined in a central laboratory from a timed 24-h urine collection. Complete data were available from 2696 persons with IDDM from 30 centres in 16 European countries. In individuals who reported protein consumption less than 20% of total food energy intake, mean AER was below 20 microg/min. In those in whom protein intake constituted more than 20%, mean AER increased, a trend particularly pronounced in individuals with hypertension and/or poor metabolic control. Trends reached statistical significance for intakes of total protein (% of energy, p = 0.01) and animal protein (% of energy, p = 0.02), while no association was seen for vegetable protein (p = 0.83). These findings support the current recommendation for people with diabetes not to exceed a protein intake of 20% of total energy. Monitoring and adjustment of dietary protein appears particularly desirable for individuals with AER exceeding 20 microg/min (approximately 30 mg/24h), especially when arterial pressure is raised and/or diabetic control is poor. SN - 0012-186X UR - https://www.unboundmedicine.com/medline/citation/9349605/full_citation L2 - https://medlineplus.gov/diabetickidneyproblems.html DB - PRIME DP - Unbound Medicine ER -