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A fatal case of severe SLE complicated by invasive aspergillosis.
Rheumatol Int 1997; 17(3):127-30RI

Abstract

We report on the case of a 25-year-old female with severe systemic lupus erythematosus (SLE) who presented with pancytopenia, fever, arthralgia and abdominal pain. After antibiotic treatment, the patient was afebrile for 3 days before her temperature rose again. Dyspnoea and cough pointed towards pneumonia which was confirmed by X-ray. Different antibiotics and the antimycotic agent fluconazol were given. The lupus flare was treated with high-dose prednisolone. After a couple of days, the dyspnoea increased and mechanical ventilation became necessary. Bronchoscopy and transbronchial biopsy revealed the diagnosis of invasive aspergilloses. Despite of an immediate treatment with amphotericin B, the patient died because of respiratory insufficiency. The literature on aspergillosis in SLE is reviewed and prophylactic, diagnostic and therapeutic options are discussed for this infectious complication which has an 80% mortality in patients with SLE.

Authors+Show Affiliations

University of Saarland Medical Center, Homburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

9352608

Citation

Zuber, M, et al. "A Fatal Case of Severe SLE Complicated By Invasive Aspergillosis." Rheumatology International, vol. 17, no. 3, 1997, pp. 127-30.
Zuber M, Daus H, Koch B, et al. A fatal case of severe SLE complicated by invasive aspergillosis. Rheumatol Int. 1997;17(3):127-30.
Zuber, M., Daus, H., Koch, B., & Pfreundschuh, M. (1997). A fatal case of severe SLE complicated by invasive aspergillosis. Rheumatology International, 17(3), pp. 127-30.
Zuber M, et al. A Fatal Case of Severe SLE Complicated By Invasive Aspergillosis. Rheumatol Int. 1997;17(3):127-30. PubMed PMID: 9352608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A fatal case of severe SLE complicated by invasive aspergillosis. AU - Zuber,M, AU - Daus,H, AU - Koch,B, AU - Pfreundschuh,M, PY - 1997/1/1/pubmed PY - 1997/11/14/medline PY - 1997/1/1/entrez SP - 127 EP - 30 JF - Rheumatology international JO - Rheumatol. Int. VL - 17 IS - 3 N2 - We report on the case of a 25-year-old female with severe systemic lupus erythematosus (SLE) who presented with pancytopenia, fever, arthralgia and abdominal pain. After antibiotic treatment, the patient was afebrile for 3 days before her temperature rose again. Dyspnoea and cough pointed towards pneumonia which was confirmed by X-ray. Different antibiotics and the antimycotic agent fluconazol were given. The lupus flare was treated with high-dose prednisolone. After a couple of days, the dyspnoea increased and mechanical ventilation became necessary. Bronchoscopy and transbronchial biopsy revealed the diagnosis of invasive aspergilloses. Despite of an immediate treatment with amphotericin B, the patient died because of respiratory insufficiency. The literature on aspergillosis in SLE is reviewed and prophylactic, diagnostic and therapeutic options are discussed for this infectious complication which has an 80% mortality in patients with SLE. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/9352608/A_fatal_case_of_severe_SLE_complicated_by_invasive_aspergillosis_ L2 - http://www.diseaseinfosearch.org/result/625 DB - PRIME DP - Unbound Medicine ER -