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Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.
Cancer Res. 1997 Nov 01; 57(21):4682-6.CR

Abstract

Gastrinomas and insulinomas are frequent in multiple endocrine neoplasia type 1 (MEN1). The MEN1 tumor suppressor gene was recently identified. To elucidate the etiological role of the MEN1 gene in sporadic enteropancreatic endocrine tumorigenesis, we analyzed tumors (28 gastrinomas and 12 insulinomas) from 40 patients for MEN1 gene mutations and allelic deletions. One copy of the MEN1 gene was found to be deleted in 25 of 27 (93%) sporadic gastrinomas and in 6 of 12 (50%) sporadic insulinomas. MEN1 gene mutations were identified in 9 of 27 (33%) sporadic gastrinomas and 2 of 12 (17%) insulinomas and were not seen in corresponding germ-line DNA sequence. A specific MEN1 mutation was detected in one gastrinoma and in the corresponding germ-line DNA of a patient who had no family history of MEN1. Somatic MEN1 gene mutations and deletions play a critical role in the tumorigenesis of sporadic gastrinomas and may also contribute to the development of a subgroup of insulinomas.

Authors+Show Affiliations

Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9354421

Citation

Zhuang, Z, et al. "Somatic Mutations of the MEN1 Tumor Suppressor Gene in Sporadic Gastrinomas and Insulinomas." Cancer Research, vol. 57, no. 21, 1997, pp. 4682-6.
Zhuang Z, Vortmeyer AO, Pack S, et al. Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Res. 1997;57(21):4682-6.
Zhuang, Z., Vortmeyer, A. O., Pack, S., Huang, S., Pham, T. A., Wang, C., Park, W. S., Agarwal, S. K., Debelenko, L. V., Kester, M., Guru, S. C., Manickam, P., Olufemi, S. E., Yu, F., Heppner, C., Crabtree, J. S., Skarulis, M. C., Venzon, D. J., Emmert-Buck, M. R., ... Lubensky, I. A. (1997). Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. Cancer Research, 57(21), 4682-6.
Zhuang Z, et al. Somatic Mutations of the MEN1 Tumor Suppressor Gene in Sporadic Gastrinomas and Insulinomas. Cancer Res. 1997 Nov 1;57(21):4682-6. PubMed PMID: 9354421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas. A1 - Zhuang,Z, AU - Vortmeyer,A O, AU - Pack,S, AU - Huang,S, AU - Pham,T A, AU - Wang,C, AU - Park,W S, AU - Agarwal,S K, AU - Debelenko,L V, AU - Kester,M, AU - Guru,S C, AU - Manickam,P, AU - Olufemi,S E, AU - Yu,F, AU - Heppner,C, AU - Crabtree,J S, AU - Skarulis,M C, AU - Venzon,D J, AU - Emmert-Buck,M R, AU - Spiegel,A M, AU - Chandrasekharappa,S C, AU - Collins,F S, AU - Burns,A L, AU - Marx,S J, AU - Lubensky,I A, PY - 1997/11/14/pubmed PY - 1997/11/14/medline PY - 1997/11/14/entrez SP - 4682 EP - 6 JF - Cancer research JO - Cancer Res VL - 57 IS - 21 N2 - Gastrinomas and insulinomas are frequent in multiple endocrine neoplasia type 1 (MEN1). The MEN1 tumor suppressor gene was recently identified. To elucidate the etiological role of the MEN1 gene in sporadic enteropancreatic endocrine tumorigenesis, we analyzed tumors (28 gastrinomas and 12 insulinomas) from 40 patients for MEN1 gene mutations and allelic deletions. One copy of the MEN1 gene was found to be deleted in 25 of 27 (93%) sporadic gastrinomas and in 6 of 12 (50%) sporadic insulinomas. MEN1 gene mutations were identified in 9 of 27 (33%) sporadic gastrinomas and 2 of 12 (17%) insulinomas and were not seen in corresponding germ-line DNA sequence. A specific MEN1 mutation was detected in one gastrinoma and in the corresponding germ-line DNA of a patient who had no family history of MEN1. Somatic MEN1 gene mutations and deletions play a critical role in the tumorigenesis of sporadic gastrinomas and may also contribute to the development of a subgroup of insulinomas. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/9354421/Somatic_mutations_of_the_MEN1_tumor_suppressor_gene_in_sporadic_gastrinomas_and_insulinomas_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=9354421 DB - PRIME DP - Unbound Medicine ER -