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Interaction of angiotensin II and TGF-beta 1 in the rat remnant kidney.
J Am Soc Nephrol. 1997 Nov; 8(11):1732-8.JA

Abstract

An interaction between angiotensin (Ang) II and transforming growth factor (TGF)-beta 1 is gaining increasing recognition. Ang II has been implicated in the progression of renal disease, and TGF-beta 1 is a potent fibrosis-promoting cytokine. We sought to determine whether the beneficial effects of renin-angiotensin system blockade on remnant kidney function were associated with a reduction in renal TGF-beta 1 in this model of chronic renal failure. After subtotal renal ablation, rats fed a 40% protein diet and treated with losartan not only had a reduction in systolic BP (96 +/- 8 versus 130 +/- 8 mmHg, P < 0.05, losartan versus control) and urinary protein excretion (4 +/- 5 versus 23 +/- 20 g/d, P < 0.05, losartan versus control), but also exhibited a reduction in renal TGF-beta 1 mRNA (194 +/- 64 versus 411 +/- 101 optical density units, P < 0.05, losartan versus control) and TGF-beta 1 protein levels (9.8 +/- 2.5 versus 18.6 +/- 5.8 ng/g of renal tissue, P < 0.05, losartan versus control). The elevation of TGF-beta 1 in the remnant kidney was most pronounced in the scar region (22.9 +/- 13.1 versus 5.8 +/- 3.7 ng/g, P < 0.05, scar versus nonscar). A combination of reserpine, hydralazine, and hydrochlorothiazide, although effective in lowering systemic BP in this model of chronic renal failure, was not associated with a reduction in proteinuria or TGF-beta 1. We conclude that in this model of progressive renal injury, Ang II antagonism may exert a beneficial effect in part by its negative influence on TGF-beta 1.

Authors+Show Affiliations

University of Manitoba, Winnipeg, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9355076

Citation

Junaid, A, et al. "Interaction of Angiotensin II and TGF-beta 1 in the Rat Remnant Kidney." Journal of the American Society of Nephrology : JASN, vol. 8, no. 11, 1997, pp. 1732-8.
Junaid A, Rosenberg ME, Hostetter TH. Interaction of angiotensin II and TGF-beta 1 in the rat remnant kidney. J Am Soc Nephrol. 1997;8(11):1732-8.
Junaid, A., Rosenberg, M. E., & Hostetter, T. H. (1997). Interaction of angiotensin II and TGF-beta 1 in the rat remnant kidney. Journal of the American Society of Nephrology : JASN, 8(11), 1732-8.
Junaid A, Rosenberg ME, Hostetter TH. Interaction of Angiotensin II and TGF-beta 1 in the Rat Remnant Kidney. J Am Soc Nephrol. 1997;8(11):1732-8. PubMed PMID: 9355076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of angiotensin II and TGF-beta 1 in the rat remnant kidney. AU - Junaid,A, AU - Rosenberg,M E, AU - Hostetter,T H, PY - 1997/11/14/pubmed PY - 1997/11/14/medline PY - 1997/11/14/entrez SP - 1732 EP - 8 JF - Journal of the American Society of Nephrology : JASN JO - J. Am. Soc. Nephrol. VL - 8 IS - 11 N2 - An interaction between angiotensin (Ang) II and transforming growth factor (TGF)-beta 1 is gaining increasing recognition. Ang II has been implicated in the progression of renal disease, and TGF-beta 1 is a potent fibrosis-promoting cytokine. We sought to determine whether the beneficial effects of renin-angiotensin system blockade on remnant kidney function were associated with a reduction in renal TGF-beta 1 in this model of chronic renal failure. After subtotal renal ablation, rats fed a 40% protein diet and treated with losartan not only had a reduction in systolic BP (96 +/- 8 versus 130 +/- 8 mmHg, P < 0.05, losartan versus control) and urinary protein excretion (4 +/- 5 versus 23 +/- 20 g/d, P < 0.05, losartan versus control), but also exhibited a reduction in renal TGF-beta 1 mRNA (194 +/- 64 versus 411 +/- 101 optical density units, P < 0.05, losartan versus control) and TGF-beta 1 protein levels (9.8 +/- 2.5 versus 18.6 +/- 5.8 ng/g of renal tissue, P < 0.05, losartan versus control). The elevation of TGF-beta 1 in the remnant kidney was most pronounced in the scar region (22.9 +/- 13.1 versus 5.8 +/- 3.7 ng/g, P < 0.05, scar versus nonscar). A combination of reserpine, hydralazine, and hydrochlorothiazide, although effective in lowering systemic BP in this model of chronic renal failure, was not associated with a reduction in proteinuria or TGF-beta 1. We conclude that in this model of progressive renal injury, Ang II antagonism may exert a beneficial effect in part by its negative influence on TGF-beta 1. SN - 1046-6673 UR - https://www.unboundmedicine.com/medline/citation/9355076/Interaction_of_angiotensin_II_and_TGF_beta_1_in_the_rat_remnant_kidney_ L2 - http://jasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=9355076 DB - PRIME DP - Unbound Medicine ER -