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Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet.
Am J Physiol 1997; 273(4):G899-904AJ

Abstract

We have hypothesized that permanent changes caused by poor growth during early development due to maternal malnutrition may be exacerbated by overnutrition of offspring in later life. To test this hypothesis, rats were exposed to a maternal 20% protein diet or an isocaloric 8% protein diet during fetal and postnatal life. All offspring were weaned onto laboratory chow. At 6 wk, rats were fed laboratory chow or a highly palatable diet (high fat and high calorie with adequate protein) and studied at 12 wk after a 48-h fast. The highly palatable diet resulted in excess weight gain and higher plasma insulin levels in all animals. Plasma insulin concentrations were significantly increased in male offspring of dams fed a reduced-protein diet compared with male offspring of dams fed an adequate-protein diet, but no differences were observed between the female offspring. The key hepatic enzymes of glucose homeostasis programmed in offspring of protein-restricted rat dams retained the ability to respond to overnutrition during adult life. In these offspring, however, the enzymes were regulated around a "set point" that was different from that in the controls.

Authors+Show Affiliations

Department of Clinical Biochemistry, University of Cambridge, Addenbrooke's Hospital, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9357833

Citation

Desai, M, et al. "Regulation of Hepatic Enzymes and Insulin Levels in Offspring of Rat Dams Fed a Reduced-protein Diet." The American Journal of Physiology, vol. 273, no. 4, 1997, pp. G899-904.
Desai M, Byrne CD, Meeran K, et al. Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. Am J Physiol. 1997;273(4):G899-904.
Desai, M., Byrne, C. D., Meeran, K., Martenz, N. D., Bloom, S. R., & Hales, C. N. (1997). Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. The American Journal of Physiology, 273(4), pp. G899-904. doi:10.1152/ajpgi.1997.273.4.G899.
Desai M, et al. Regulation of Hepatic Enzymes and Insulin Levels in Offspring of Rat Dams Fed a Reduced-protein Diet. Am J Physiol. 1997;273(4):G899-904. PubMed PMID: 9357833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of hepatic enzymes and insulin levels in offspring of rat dams fed a reduced-protein diet. AU - Desai,M, AU - Byrne,C D, AU - Meeran,K, AU - Martenz,N D, AU - Bloom,S R, AU - Hales,C N, PY - 1997/11/14/pubmed PY - 1997/11/14/medline PY - 1997/11/14/entrez SP - G899 EP - 904 JF - The American journal of physiology JO - Am. J. Physiol. VL - 273 IS - 4 N2 - We have hypothesized that permanent changes caused by poor growth during early development due to maternal malnutrition may be exacerbated by overnutrition of offspring in later life. To test this hypothesis, rats were exposed to a maternal 20% protein diet or an isocaloric 8% protein diet during fetal and postnatal life. All offspring were weaned onto laboratory chow. At 6 wk, rats were fed laboratory chow or a highly palatable diet (high fat and high calorie with adequate protein) and studied at 12 wk after a 48-h fast. The highly palatable diet resulted in excess weight gain and higher plasma insulin levels in all animals. Plasma insulin concentrations were significantly increased in male offspring of dams fed a reduced-protein diet compared with male offspring of dams fed an adequate-protein diet, but no differences were observed between the female offspring. The key hepatic enzymes of glucose homeostasis programmed in offspring of protein-restricted rat dams retained the ability to respond to overnutrition during adult life. In these offspring, however, the enzymes were regulated around a "set point" that was different from that in the controls. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/9357833/Regulation_of_hepatic_enzymes_and_insulin_levels_in_offspring_of_rat_dams_fed_a_reduced_protein_diet_ L2 - http://www.physiology.org/doi/full/10.1152/ajpgi.1997.273.4.G899?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -