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Marijuana. Respiratory tract effects.
Clin Rev Allergy Immunol. 1997 Fall; 15(3):243-69.CR

Abstract

Daily marijuana smoking has been clearly shown to have adverse effects on pulmonary function and produce respiratory symptomatology (cough, wheeze, and sputum production) similar to that of tobacco smokers. Based on the tobacco experience, decrements in pulmonary function may be predictive of the future development of chronic obstructive pulmonary disease (COPD). However, in the absence of alpha-1-antitrypsin deficiency, the habitual marijuana-only smoker would likely have to smoke 4-5 joints per day for a span of at least 30 yr in order to develop overt manifestations of COPD. The mutagenic/carcinogenic properties of marijuana smoke are also well-established. The potential for induction of laryngeal, oropharyngeal, and possibly bronchogenic carcinoma from marijuana has been documented by several case reports and observational series. Despite this, a relative risk ratio for the development of these tumors has not yet been quantified. Based on a higher frequency of case reports for upper airway cancer compared to bronchogenic carcinoma, marijuana smoking may have a more deleterious effect on the upper respiratory tract. However, this hypothesis remains speculative at best, pending confirmation by longitudinal studies.

Authors+Show Affiliations

Division of Pulmonary and Critical Care Medicine, University of California at Davis, Sacramento 95817, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9358987

Citation

Van Hoozen, B E., and C E. Cross. "Marijuana. Respiratory Tract Effects." Clinical Reviews in Allergy & Immunology, vol. 15, no. 3, 1997, pp. 243-69.
Van Hoozen BE, Cross CE. Marijuana. Respiratory tract effects. Clin Rev Allergy Immunol. 1997;15(3):243-69.
Van Hoozen, B. E., & Cross, C. E. (1997). Marijuana. Respiratory tract effects. Clinical Reviews in Allergy & Immunology, 15(3), 243-69.
Van Hoozen BE, Cross CE. Marijuana. Respiratory Tract Effects. Clin Rev Allergy Immunol. 1997;15(3):243-69. PubMed PMID: 9358987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marijuana. Respiratory tract effects. AU - Van Hoozen,B E, AU - Cross,C E, PY - 1997/11/14/pubmed PY - 1997/11/14/medline PY - 1997/11/14/entrez SP - 243 EP - 69 JF - Clinical reviews in allergy & immunology JO - Clin Rev Allergy Immunol VL - 15 IS - 3 N2 - Daily marijuana smoking has been clearly shown to have adverse effects on pulmonary function and produce respiratory symptomatology (cough, wheeze, and sputum production) similar to that of tobacco smokers. Based on the tobacco experience, decrements in pulmonary function may be predictive of the future development of chronic obstructive pulmonary disease (COPD). However, in the absence of alpha-1-antitrypsin deficiency, the habitual marijuana-only smoker would likely have to smoke 4-5 joints per day for a span of at least 30 yr in order to develop overt manifestations of COPD. The mutagenic/carcinogenic properties of marijuana smoke are also well-established. The potential for induction of laryngeal, oropharyngeal, and possibly bronchogenic carcinoma from marijuana has been documented by several case reports and observational series. Despite this, a relative risk ratio for the development of these tumors has not yet been quantified. Based on a higher frequency of case reports for upper airway cancer compared to bronchogenic carcinoma, marijuana smoking may have a more deleterious effect on the upper respiratory tract. However, this hypothesis remains speculative at best, pending confirmation by longitudinal studies. SN - 1080-0549 UR - https://www.unboundmedicine.com/medline/citation/9358987/Marijuana__Respiratory_tract_effects_ L2 - https://doi.org/10.1007/BF02737700 DB - PRIME DP - Unbound Medicine ER -